MmuEX0028107

From VastDB

Exon Skipping

Gene
Description
muscleblind-like 2 [Source:MGI Symbol;Acc:MGI:2145597]
Coordinates
chr14:120788122-120795826:+chr14:120388900-120396604:+
Coord C1 exon
chr14:120788122-120788385chr14:120388900-120389163
Coord A exon
chr14:120794934-120794987chr14:120395712-120395765
Coord C2 exon
chr14:120795673-120795826chr14:120396451-120396604
Length
5454 bp
Sequences
Splice sites
3' ss Seq
TCGCTGCCTGTTATTAAAAGACT
3' ss Score
2.9
5' ss Seq
CTGGTACTT
5' ss Score
4.74
Exon sequences
Seq C1 exon
GTATGCAGGGAGTTCCAGCGAGGAAACTGTGCCCGGGGAGAGACAGACTGCCGCTTTGCACACCCGGCAGACAGCACCATGATCGACACAAACGACAACACCGTAACCGTTTGTATGGATTACATAAAGGGGCGTTGCATGAGGGAGAAATGCAAATATTTTCACCCTCCTGCACACTTGCAGGCCAAAATCAAAGCTGCGCAGCACCAAGCCAACCAGGCCGCGGTGGCCGCCCAGGCAGCCGCGGCCGCGGCCACAGTCATG
GTATGCAGGGAGTTCCAGCGAGGAAACTGTGCCCGGGGAGAGACAGACTGCCGCTTTGCACACCCGGCAGACAGCACCATGATCGACACAAACGACAACACCGTAACCGTTTGTATGGATTACATAAAGGGGCGTTGCATGAGGGAGAAATGCAAATATTTTCACCCTCCTGCACACTTGCAGGCCAAAATCAAAGCTGCGCAGCACCAAGCCAACCAGGCCGCGGTGGCCGCCCAGGCAGCCGCGGCCGCGGCCACAGTCATG
Seq A exon
ACTCAGTCGACTGCCAAAGCACTGAAGCGACCTCTCGAAGCAACTGTAGACCTG
ACTCAGTCGACTGCCAAAGCACTGAAGCGACCTCTCGAAGCAACTGTAGACCTG
Seq C2 exon
GCCTTCCCTCCGGGTGCTCTTCATCCCTTACCAAAGAGACAAGCACTTGAAAAAAGCAACGGGGCCAGCACGGTCTTCAACCCCAGCGTCTTGCACTACCAGCAGGCTCTGACCAGTGCGCAGCTGCAGCAGCACACGGCGTTCATCCCCACAG
GCCTTCCCTCCGGGTGCTCTTCATCCCTTACCAAAGAGACAAGCACTTGAAAAAAGCAACGGGGCCAGCACGGTCTTCAACCCCAGCGTCTTGCACTACCAGCAGGCTCTGACCAGTGCGCAGCTGCAGCAGCACACGGCGTTCATCCCCACAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000022139_MULTIEX3-3/3=2-C2
Average complexity
SS
Mappability confidence:
100%=100=%
Protein Impact
Alternative protein isoforms (Ref)

Show structural model

Features
Disorder rate:
C1=0.321 A=1.000 C2=0.490
 

Domain overlap (PROSITE):

Info
C1:
PS50103=ZF_C3H1=PD(79.3=26.1),PS50103=ZF_C3H1=WD(100=30.7),PS50310=ALA_RICH=PU(93.8=34.1)
A:
NO
C2:
PS50310=ALA_RICH=PD(0.1=0.0)
Domain overlap (PFAM):

Info
C1:
PF0064219=zf-CCCH=PD(81.5=25.0)
A:
NO
C2:
NO

Degree:
NA
Betweeness:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
TTTCACCCTCCTGCACACTTG
R:
GTAAGGGATGAAGAGCACCCG
Band lengths:
136-190
Annotated function
There are 1 annotated functions for this event
PMID: 21454535
Inferred from MBNL1: The exon 5 and 6 regions are both needed to control the nuclear localization of MBNL1


GENOMIC CONTEXT

UCSC image
UCSC image

INCLUSION PATTERN