DmeEX0000185 @ dm6
Exon Skipping
Gene
FBgn0261238 | Alh
Description
The gene Alhambra is referred to in FlyBase by the symbol DmelAlh (CG1070, FBgn0261238). It is a protein_coding_gene from Dmel. It has 14 annotated transcripts and 14 polypeptides (13 unique). Gene sequence location is 3R:7094596..7124185. Its molecular function is described by: DNA-binding transcription factor activity. It is involved in the biological process described with: larval somatic muscle development; regulation of transcription, DNA-templated; haltere development; molting cycle, chitin-based cuticle; instar larval development. 88 alleles are reported. The phenotypes of these alleles manifest in: embryonic/larval somatic muscle; wing; larva; embryonic/larval nervous system; RP2 motor neuron. The phenotypic classes of alleles include: phenotype; fertile; courtship behavior defective; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr3R:7098555-7101497:-
Coord C1 exon
chr3R:7101137-7101497
Coord A exon
chr3R:7098826-7099522
Coord C2 exon
chr3R:7098555-7098732
Length
697 bp
Sequences
Splice sites
3' ss Seq
ACGTCGAAACCCAACAACAGAAC
3' ss Score
0.45
5' ss Seq
CAGGTAAGG
5' ss Score
11.08
Exon sequences
Seq C1 exon
AATCCCATTCGGCATCGTCGCGCAGCAGTGGTGCACAATCTCAGCATCAGCAGCAGCTAAGCAATGCTTTGGTTGGTCCGCCCATGGGAGGATCCGCTGGGGCTTTTCATGGCGGAACAACCAGCGCTGGGTCCTCGTCGGTCATCCAGCAGCAGAGCGGCAAGTCATCGCCGGCTCTGGGCACGCTAGTCAGTGGCAACAGTGGTGGTAGCATAATCTCCGCCAGTGGCTTTCCACTACCGAGTGGTAATCTCACTGCCACGACCACTGAGAGCGGCAACTTGAAGATCAGCTATGAGAAACAGACGACACGAGTGCAACAATTGCAGGAGCAGGAGGCGCCACCGGCCAGACGCAGCAG
Seq A exon
AACGCTTGATCTGAGCACGGCAAGCGCTTCATCGTCATCGCCATCTGCAGTGCCCGCGACAACATCTCCCTTGGTCGTACTGAGTAACCAATTGCCACTTAACTCGGTGGCAGCAAGTAGTTCCACCGGTGGTCTGAAGTTTACCTACGAGAGTCAGACCCAGATGGACGTGCCCATGATGCCTGTGAGCGCCATAAAGGATTCCCCGCCCAGTTCGCCCGGCTCAGAGATAGGATCGGCCATGCACTCCGCAACTACTGCACCCGGTTCCCTGACTGGAGCTTCGACAGCGGCGACTGCTCAACCTGGAAATGTACGGAAGCGTGGACGCAAGGCCAAAGATGCGACGATAGCTGCTGCAGCGGCGGCAGCGGCAGCAGCAGCTGCTCTCAGCAATTCTCAACAGGATCTCAAGGATGTGCGCATACTCCAGAATGGGGCGAGCAATACACCGGGCAATCCAGCTGGCAGCACACCAACGCCTCCTGCTACTCCCGCTTCGTCTAATGCTGTCAGCTCAGCCAGTTCGATCATTACACACACGGCCGCGCATATGCTGGGCAACCAGATCAACCCAAACAGCAGCGTGGCCCAGAAGCTGTCCGAGCAGCTGCACATGGAGGTCCAGGATCACTCGATCTACACTCCCGATTCAATGAACTCGCAATACGCCGGAGTTCCGTTCCCCGGCAAGCAG
Seq C2 exon
CGTAACTCCACTGCCGTTCCTAGCAACGCCACGCCAGCTCAAAATCCGCTGCAATCGATGTTCAGCGGTGGCGGCATGAACGGCAACATGCCCATTCCGCAAAGTCTGGAGCAGCTGCTGGAGCGCCAGTGGGAGCAGGGCTCGCAGTTTCTCATGGAGCAAGCGCAGCACTTTGACA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261238-'24-14,'24-13,26-14
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.958 A=0.859 C2=0.641
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0303393
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0081129, FBpp0081130, FBpp0081131, FBpp0112112, FBpp0289721, FBpp0289722, FBpp0306733, FBpp0306734, FBpp0306735, FBpp0306736, FBpp0306737, FBpp0306738
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAGTGGTGCACAATCTCAGCA
R:
GGAACGGCAGTGGAGTTACG
Band lengths:
356-1053
Functional annotations
There are 1 annotated functions for this event
PMID: 11266362
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI000248; ELM sequence: PLVVL; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)