DmeEX0002221 @ dm6
Exon Skipping
Gene
FBgn0087011 | CG41520
Description
This gene is referred to in FlyBase by the symbol DmelCG41520 (FBgn0087011). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 2R:1649061..1778937. Its molecular function is described by: transmembrane receptor protein tyrosine kinase activator activity; signaling receptor binding. It is involved in the biological process described with: negative regulation of apoptotic process; activation of transmembrane receptor protein tyrosine kinase activity. 2 alleles are reported. No phenotypic data is available. No phenotypic class data is available. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages.
Coordinates
chr2R:1727672-1762055:+
Coord C1 exon
chr2R:1727672-1727978
Coord A exon
chr2R:1731185-1731797
Coord C2 exon
chr2R:1761924-1762055
Length
613 bp
Sequences
Splice sites
3' ss Seq
AAACGTTATGTTTTTTATAGCTA
3' ss Score
6.57
5' ss Seq
GAGGTAAGT
5' ss Score
11.08
Exon sequences
Seq C1 exon
CTACACTGACACGGATGAAAATTCAAGAACGGAGATCTTACTTTTATCCCTCTCTAATATTCAACCAACCATAGTTAATAAAACTATAACTACACCGTTTACTTCCACACCTGGAGATGGAGATGTGCTCGGTCCGCTACATTCGGAGTCGTTAGACTCTAACCGAACTCACTACAACGGACCAGCAGTCAATGGATTGAAATCTGCAAATCGCAAAGACCGAATTATCTTTCCAAGCATAAAAAAAAAACCAGCATTTCTAAACACAACGATTTCCAATGATTTTTGGGCGCTCAAGGATGTAAAA
Seq A exon
CTATAGCTTTATGTGTCACTTGTGACTGGCGGTAGAGTGCGCACGAGAAGCGAAGCGAGAAGCTACCAGCAAAGCGAGAGGATGGCAGAGTGAATGCTTTTCGAGAAATGAACTACTTGGCTTGTACTTGTAAGAAGCGGTAACGTGGTCGATCCATTAATCACAAGCATCGTCATCAGAAAATGTCCACTCAATATAAGAAAGTGAAGCTAAAAATGATTTCTGTCTATCTGTTGCGAATCAAAACTATTTCTTAGGCATATTCATCTTGGAGAAAAATTATGTTGATAAGTACAAGTGTAATCAAAGCAGTTTGATCCATGGTAAACTATTTCCGCATAGCTCCCTTAAAGATTCTCTCTATTATTGAACGTAATGGATTCGGACGAGAAATTTTTTACAAAAAAAAAAAATGGCGTCAACTCCCTCAACTGCAATAGGAATGAAAAAGGCGAATCAATAATTTGTATAATGCTTTACGAAACCACCCAGAAAGGTTCTTTAACTATGCGTGGATGTCTATTTCGACTTTTGATTATATTTTAAATAAAATTAGTAGTCGTATGACGAAGAATTGGCCAAATTTTGTTAAACACCCTATACTAACATTGAG
Seq C2 exon
GGATTTTCCTGTGTAGACATTTTAAATGCTGGAATGAAACAATCAGGAGTATTTTATTTACAAATTCGTGGTACGACGTATTGGTTTTTAAAGGTATACTGCGATCAAGAAACGACGGATGGAGGTTGGACG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0087011_MULTIEX1-1/2=C1-2
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.332 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0014713=Fibrinogen_C=PU(0.1=0.0)
A:
NO
C2:
PF0014713=Fibrinogen_C=FE(19.5=100)
Main Inclusion Isoform:
FBtr0114111fB266
Main Skipping Isoform:
FBpp0112834
Other Inclusion Isoforms:
FBpp0291737
Other Skipping Isoforms:
FBpp0112835, FBpp0291738
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACCGTTTACTTCCACACCTGG
R:
CCAACCTCCATCCGTCGTTTC
Band lengths:
343-956
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)