DmeEX0004037 @ dm6
Exon Skipping
Gene
FBgn0013813 | Dhc98D
Description
The gene Dynein heavy chain at 89D is referred to in FlyBase by the symbol DmelDhc98D (CG1842, FBgn0013813). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 3R:28486953..28519398. Its molecular function is described by: ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding; ATP binding; dynein light intermediate chain binding. It is involved in the biological process described with: microtubule-based movement; cilium movement. 5 alleles are reported. No phenotypic data is available. No phenotypic class data is available. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period, in stages of adults of both sexes.
Coordinates
chr3R:28515521-28517456:+
Coord C1 exon
chr3R:28515521-28515652
Coord A exon
chr3R:28516551-28516586
Coord C2 exon
chr3R:28517245-28517456
Length
36 bp
Sequences
Splice sites
3' ss Seq
ATATATTCGCACACACGAAGTGA
3' ss Score
-2.54
5' ss Seq
CTGGTAAAG
5' ss Score
5.75
Exon sequences
Seq C1 exon
CGCACATCGACAAACTGCCGCTGGTCAACAAGCCGGATGTATTTGGTTTGCATCCGAACGCGGAAATCGGTTATTACACAATGGCGGCACGCAACATTTGGAACAGTTTGATTGAGCTGCAGCCACAGACGG
Seq A exon
TGACCAAGTGGACACCGACGACCGAAGTCAATCCTG
Seq C2 exon
GTGAGGGAACCGGTGGAATCAGCCGCGACGACTTCATCGACTCGGTGGCAGCCGGCATACTGAAGAAGCTGCCCCCCGCCTTCGAGACATGGCGCATCCGCAAACAGATCCAGATGAGCCTGTCACCAACCGGGGTGGTGCTGCTCCAGGAGCTGGACCGCTTTAATCTGCTGGTCGTACGGATCAAGAAGACGCTGGAGCTGCTACGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0013813_CASSETTE2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.769 C2=0.014
Domain overlap (PFAM):
C1:
PF0302810=Dynein_heavy=FE(6.2=100)
A:
PF0302810=Dynein_heavy=FE(1.7=100)
C2:
PF0302810=Dynein_heavy=FE(9.9=100)
Main Inclusion Isoform:
FBtr0301302fB468
Main Skipping Isoform:
FBpp0290517
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0290518, FBpp0307963
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGCACGCAACATTTGGAACAG
R:
GGGGGCAGCTTCTTCAGTATG
Band lengths:
123-159
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)