Special

DmeEX0004375 @ dm6

Exon Skipping

Gene
FBgn0266084 | Fhos
Description
The gene Formin homology 2 domain containing is referred to in FlyBase by the symbol DmelFhos (CG42610, FBgn0266084). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (8 unique). Gene sequence location is 3L:8753619..8798719. Its molecular function is described by: actin filament binding. It is involved in the biological process described with 12 unique terms, many of which group under: anatomical structure morphogenesis; epithelium development; multicellular organismal process; positive regulation of cellular component movement; programmed cell death involved in cell development. 43 alleles are reported. The phenotypes of these alleles manifest in: intracellular non-membrane-bounded organelle; multicellular structure; intracellular organelle; cytoskeleton; intracellular. The phenotypic classes of alleles include: increased mortality during development; stress response defective; phenotype; fertile.
Coordinates
chr3L:8766442-8782657:+
Coord C1 exon
chr3L:8766442-8766629
Coord A exon
chr3L:8776997-8777317
Coord C2 exon
chr3L:8782548-8782657
Length
321 bp
Sequences
Splice sites
3' ss Seq
ATGGCAAAAATCCATTTCAGTGT
3' ss Score
3.03
5' ss Seq
AGCGTAAGA
5' ss Score
6.21
Exon sequences
Seq C1 exon
TCAGTTGCCTTGCGAACGCGCTCAAGTTCAGTCGCTTCGATTTTGTCGCGGGTGAAACAACCACCGTGGAATCAAAAACCAAACTTCGCTCAGCTGCGCGCGTCGCGTTGCCCTGTGTGTGTGCTTTTGTTGTTGTTGAGGGCAACGTTTAAAATATATTTAAACTGCCTTAGTTGCTACAACAATTG
Seq A exon
TGTTCGTTCAAGTGTTCGAGTGAAAATGTAAATAAATCATAGAGCGAGTGAGAGAGAGAAAATCGCGAAAAGTAAATAGACCTCGAATTAAGTAAGACAAATGTGCAAAAGTGATTGAAAGCCGCGTCGAAAATGATTGTGAAAATGGAGCCGGACGAACTGATCACATTCCGTGTCCAGTATCTGGTGGACAGCGATCCGCTCTCGGCGTGCACCGCCTTCCCGATCCCGGTGCGGGCGCCCACCTACGCCTTCGCCACCACCATGCCGCTGGCCAATCAGCTGGGCACAATCCTGCGGCTGCTGAATGCACCACAAAGC
Seq C2 exon
ATCGACGATGCAGCCATTCAGGTGTACAAGGATGGCGACTACGGAGCCTACTTGGATCTGGAGTCATCGCTGGCCGAACAGGCCGAGGAAATCGAGGGAGTCAACGTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0266084-'6-6,'6-5,12-6
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref, Alt. ATG (>10 exons))

No structure available
Features
Disorder rate (Iupred):
  C1=NA A=0.000 C2=0.054
Domain overlap (PFAM):

C1:
NA
A:
NO
C2:
NO


Main Inclusion Isoform:
FBpp0291739


Main Skipping Isoform:
FBtr0333888fB502


Other Inclusion Isoforms:
FBpp0291295, FBpp0291296, FBpp0291740, FBpp0297586


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg19)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Chicken
(galGal4)
Chicken
(galGal4)
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
Zebrafish
(danRer10)
Zebrafish
(danRer10)
Primers PCR
Suggestions for RT-PCR validation
F:
TCAGTTGCCTTGCGAACGC
R:
ACGTTGACTCCCTCGATTTCC
Band lengths:
295-616
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)