DmeEX0004376 @ dm6
Exon Skipping
Gene
FBgn0266084 | Fhos
Description
The gene Formin homology 2 domain containing is referred to in FlyBase by the symbol DmelFhos (CG42610, FBgn0266084). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (8 unique). Gene sequence location is 3L:8753619..8798719. Its molecular function is described by: actin filament binding. It is involved in the biological process described with 12 unique terms, many of which group under: anatomical structure morphogenesis; epithelium development; multicellular organismal process; positive regulation of cellular component movement; programmed cell death involved in cell development. 43 alleles are reported. The phenotypes of these alleles manifest in: intracellular non-membrane-bounded organelle; multicellular structure; intracellular organelle; cytoskeleton; intracellular. The phenotypic classes of alleles include: increased mortality during development; stress response defective; phenotype; fertile.
Coordinates
chr3L:8789371-8790508:+
Coord C1 exon
chr3L:8789371-8789517
Coord A exon
chr3L:8789832-8789834
Coord C2 exon
chr3L:8790170-8790508
Length
3 bp
Sequences
Splice sites
3' ss Seq
ATGTTTTCCAATGTCTCTAGGAG
3' ss Score
9.29
5' ss Seq
GAGGTGAGT
5' ss Score
10.03
Exon sequences
Seq C1 exon
GTCAAGCTCTTCTGGAAGGAAGTGCGCGAGGACATGATACCGCAGGTGGTGGGCAAGACCATATGGGATGAGCTGCCCGATGCCAACGTGGACACACAGAAGCTCGAACATCTCTTTGAGTCCCGGGCCAAAGACTTGATGACCAAG
Seq A exon
GAG
Seq C2 exon
AAACAACAAGAGCTGAACAAGAGCAAAGAGATCATCGTGCTTGATCACAAGCGCTCCAATGCCATCAATATTGCGATCACTAAGCTGCCTCCTCCGAGGGCCATTAAGACGGCCATCCTCAAAATGGATGCCACTGTGGTCACACGGGAGGGAATCGACAAGCTACTCAATATGCTGCCCACTGATGAGGAGCGTGGCAAGATCCAGGAGGCCCAGTTATCCAACCCAGAGTTGCCCCTGGGCAGCGCCGAGCAGTTCCTTTTGACCCTGGCCTCCATTTCGGAGCTGGAAGCTCGCCTGAAATTGTGGGCTTTCCGTCTGGACTTTGACAACAGTGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0266084-MICROEX1
Average complexity
MIC-S
Mappability confidence:
NA
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.267 A=1.000 C2=0.098
Domain overlap (PFAM):
C1:
PF0218118=FH2=FE(13.1=100)
A:
PF0218118=FH2=FE(0.1=100)
C2:
PF0218118=FH2=FE(30.5=100)
Main Inclusion Isoform:
FBtr0333888fB502
Main Skipping Isoform:
FBpp0306020
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0291295, FBpp0291296, FBpp0291739, FBpp0291740, FBpp0297585, FBpp0297586, FBpp0297587, FBpp0306021
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGGCCAAAGACTTGATGACCA
R:
ATTGATGGCATTGGAGCGCTT
Band lengths:
92-95
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)