Special

DmeEX0004425 @ dm6

Exon Skipping

Gene
FBgn0262743 | Fs(2)Ket
Description
The gene Female sterile (2) Ketel is referred to in FlyBase by the symbol DmelFs(2)Ket (CG2637, FBgn0262743). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (1 unique). Gene sequence location is 2L:20734609..20750941. Its molecular function is described by: nuclear import signal receptor activity; nuclear localization sequence binding; protein binding; Ran GTPase binding. It is involved in the biological process described with: chorion-containing eggshell formation; NLS-bearing protein import into nucleus; mitotic cell cycle; protein import into nucleus; regulation of nucleocytoplasmic transport. 58 alleles are reported. The phenotypes of these alleles manifest in: material anatomical entity; egg; cell component; anatomical structure; intracellular organelle. The phenotypic classes of alleles include: female sterile germline-dependent; some die during pupal stage; phenotype; increased mortality.
Coordinates
chr2L:20734609-20735430:+
Coord C1 exon
chr2L:20734609-20734729
Coord A exon
chr2L:20734929-20735090
Coord C2 exon
chr2L:20735253-20735430
Length
162 bp
Sequences
Splice sites
3' ss Seq
AAAATCGACATTCGTTTCAGCTC
3' ss Score
5.03
5' ss Seq
AATGTGAGT
5' ss Score
7.8
Exon sequences
Seq C1 exon
ATTTAGTTCGTTCGAGGTTTTGCTTCCGTGCTTATCTTTGAATATGAAAATTTTCGATAAGCACAATCATTCAAATTTAACGATTGATTTTTGGGGAGGCAAACGCGTTTTAATACAAGTA
Seq A exon
CTCTATTTCAAATCGGAGACACAAGAAATATATTGCCTGCACTTCCCGAAGAGCAGATAAAGGTTCTGCCACCATTAAATAGGCTTATAATAATAACTAAGAAAATCGCCGTTAGGAATCCCGCGCTTTTTTACCGTTCCCGAAAAATAACCAAACAACAAT
Seq C2 exon
CCGACAGACTAGTGTTGTCTAGTAATTACGCAAAAATTCCATCACCCACACAGACGCACGAGCTGCAGAAAGAAACGGAAAGTGAAGTAGAAATCATATAGAGAGGAAAAGAGCGAAGACATGACTTCCGATATCGCCATGCAATTGATTGCCATTTTGGAAAAGACGGTGTCGCCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0262743_CASSETTE1
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact

5' UTR

No structure available
Features
Disorder rate (Iupred):
  C1=NA A=NA C2=0.000
Domain overlap (PFAM):

C1:
NA
A:
NA
C2:
NO


Main Inclusion Isoform:
NA


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCGTTCGAGGTTTTGCTTCCG
R:
GCATGGCGATATCGGAAGTCA
Band lengths:
256-418
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)