Special

DmeEX0004444 @ dm6

Exon Skipping

Gene
Description
The gene G9a is referred to in FlyBase by the symbol DmelG9a (CG2995, FBgn0040372). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is X:245978..254650. Its molecular function is described by: zinc ion binding; histone-lysine N-methyltransferase activity. It is involved in the biological process described with 12 unique terms, many of which group under: behavior; developmental process; system process; tissue development; regulation of response to external stimulus. 56 alleles are reported. The phenotypes of these alleles manifest in: somatic cell; neuron; acellular anatomical structure; cuticular specialization; membrane-bounded organelle. The phenotypic classes of alleles include: increased mortality during development; phenotype; short lived; immune response defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
Coordinates
chrX:251050-251763:+
Coord C1 exon
chrX:251050-251291
Coord A exon
chrX:251351-251541
Coord C2 exon
chrX:251602-251763
Length
191 bp
Sequences
Splice sites
3' ss Seq
ATAAACTATACTTTCAAAAGGGT
3' ss Score
3.26
5' ss Seq
TAGGTTGGC
5' ss Score
2.04
Exon sequences
Seq C1 exon
CTGCCGACTTCAACGTGCTGACTCCCATACGGGAGTACTTAAATGGCACCTGCCTTCATTTGGTGGCCCACTCGGGCACACTTCAGATGGCCTATCTCCTTCTCTGCAAAGGAGCAAGCTCACCGGATTTCGTTAATATTGTGGATTATGAACTGCGGACTGCTTTAATGTGTGCCGTGATGAACGAGAAGTGCGACATGCTGAATCTATTTCTTCAATGTGGTGCGGATGTGGCCATTAAG
Seq A exon
GGTCCCGATGGTAAGACCAGTCTGCATATTGCTGCCCAGTTAGGCAACTTGGAAGCCACACAGTTAATTGTAGACAGCTATCGAACTTCTCGAAATATTACCAGTTTTTTAAGTTTCATTGATGCCCAGGATGAAGGCGGTTGGACGGCCATGGTCTGGGCAGCAGAGCTGGGGCACACGGATATAGTTAG
Seq C2 exon
CTTCCTGCTTAACCAGGATGCTGATCCAAACATATGCGACAATGACAACAATACGGTGCTGCACTGGTCTACGCTGCACAATGATGGTCTGGACACGATTACAGTACTGCTGCAGTCAGGGGCGGACTGCAATGTACAGAATGTAGAGGGCGACACGCCTTT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0040372_MULTIEX1-2/2=1-C2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
PF127962=Ank_2=PU(24.3=30.9)
A:
PF127962=Ank_2=FE(61.2=100)
C2:
PF127962=Ank_2=PD(12.6=23.6),PF127962=Ank_2=PU(60.9=76.4)


Main Inclusion Isoform:
FBpp0070062


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0305207


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CACTCGGGCACACTTCAGATG
R:
ATTGTGCAGCGTAGACCAGTG
Band lengths:
256-447
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)