DmeEX0005660 @ dm6
Exon Skipping
Gene
FBgn0085370 | Pde11
Description
The gene Phosphodiesterase 11 is referred to in FlyBase by the symbol DmelPde11 (CG34341, FBgn0085370). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (4 unique). Gene sequence location is 2L:18532025..18590342. Its molecular function is described by: 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity. It is involved in the biological process described with: cAMP metabolic process; signal transduction; cGMP metabolic process. 21 alleles are reported. The phenotypes of these alleles manifest in: mesothoracic tergum; chaeta. The phenotypic classes of alleles include: phenotype; increased mortality; some die during P-stage; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr2L:18543262-18563172:-
Coord C1 exon
chr2L:18562710-18563172
Coord A exon
chr2L:18546525-18547044
Coord C2 exon
chr2L:18543262-18543715
Length
520 bp
Sequences
Splice sites
3' ss Seq
TCAAAAGAAAACTTCAACAGGTC
3' ss Score
1.31
5' ss Seq
CAGGTGAGA
5' ss Score
9.22
Exon sequences
Seq C1 exon
TTCGCTCGAAAAGAGAACACGCGACAAAAGCGGCCCGAAAATAAATTACATTAAAATACTGCTCTATGGCAACTATCAAAAATAAATAAGGCAATCGATCCAAAACCAAATATATCTGAAATTCGGGCAGAGTTTTGTGCGTGTGTGTAAGGAAAATCAAATTGGAAAATTGCGAATACAAAAGTAATCTTTTCGAGATGAGCCCATGAAACGTATTTAATACGCGATCAACGGTCGCGTGCTCAATTCGCCGATGCGCGTGTGTGTGTGCGTGTCTGTGTGTCGCCAAGGTGTGAAAATATACCCACATATGTACATACATAAATATCTCAGCCGATATAACGAAAAAGTATCTATATACACAACTGCATAATAGCGGTGCCACAATTAACGCAGGCCAAATAAAAGGCGTAAAATTAAGCAAAGCAATTTTGAATTTCTAGATCGTCCGCTAAGTGGCTGG
Seq A exon
GTCTTGGCAACAACTTTTTACTCTCGCCTAACTGAATAATTTACAAAGTAAATACGTTATTATGAAAGTGACACAGAGTGAAGAAAACACGAGAAATACGAGCGATCGCAGTAAAAGTGTGCAAACTAATCGAAAATTCGACAATTTCAATTGGCTGTTATCCTGCGGCCTTTTGGCGGCAGTAAAATCAACAAAATTGATTCCACAACTTCCACGACAACAGCAGCCAAAAAATACAATTTACGTTACGCGGCTGAATTGCTCAAGATCGACAAAATTCAATTCATTAAAACGGAGGGTTTAACATTCGCATTGCTGGCGGGCCCCATGGGCCAAGCGGCAAGTATGTGTCGATTTCGTGGTTGTCGCTACAAAAATAAGAACAAAAGCAGCAAGCAACAGCAGCAACAACAGCAGCAGCAACAGCAACAGCAACAGCAACATCAACAACAGCAGCAGCAAACACCAAGTCATAGTCCTCAGATTCAGCATCATTCTGAAATAATCCCAGCTACAACAG
Seq C2 exon
GCCTGCATTTGCGGAGCATCGAGGAGCCAGCGACGACGCCGCTCCAGTTCCAGCCCACTGGCAGGATGAACACGGAGCAGGGGGGCACGGGGTACGGCGGCTACGGATCCAGCGAGCACTCGCTGCTCATCGCCACACGCCACGCCGGTGTCCCCCTGCCCCTCGCCCAGCACCAGCCACTCCCCGCCCACTATCAGCCGCTGAACCACTCCGGAGCAGCCCCGCCCTCCTCATCCAACGGATCATCCTCCTCCGGCGGCGGAGTCCAGACGTCGGCCACGCCGCAGCAACAGCAGCAGTACCAGGTGCAACAGCCGTATCAGTACCAGTACCAGCATCACTATCACCACCAGGCCAACTCGCCACAACACCACAGACCCTACGATCCAGAGCACGCGCGGATGGAGGCCTGGCTGGATGAGAATCAGGAATTTGTACAGGATTATTTTATAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0085370-'11-10,'11-6,13-10
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref, Alt. ATG (>10 exons))
No structure available
Features
Disorder rate (Iupred):
C1=NA A=0.923 C2=0.931
Domain overlap (PFAM):
C1:
NA
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0111456
Main Skipping Isoform:
FBpp0111457
Other Inclusion Isoforms:
FBpp0292261, FBpp0310380
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTGCATAATAGCGGTGCCACA
R:
GGAGGAGGATGATCCGTTGGA
Band lengths:
352-872
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)