DmeEX0006067 @ dm6
Exon Skipping
Gene
FBgn0025836 | RhoGAP1A
Description
The gene Rho GTPase activating protein at 1A is referred to in FlyBase by the symbol DmelRhoGAP1A (CG40494, FBgn0025836). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (4 unique). Gene sequence location is X:127449..140340. Its molecular function is described by: Rho guanyl-nucleotide exchange factor activity; GTPase activator activity. It is involved in the biological process described with: positive regulation of GTPase activity; positive regulation of Rho protein signal transduction; Golgi organization; negative regulation of cell size. 13 alleles are reported. No phenotypic data is available. The phenotypic class of alleles includes: viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages.
Coordinates
chrX:134634-136733:+
Coord C1 exon
chrX:134634-134760
Coord A exon
chrX:136055-136075
Coord C2 exon
chrX:136635-136733
Length
21 bp
Sequences
Splice sites
3' ss Seq
CTGTTTTCTTTTCCCAACAGAAC
3' ss Score
12.3
5' ss Seq
CTTGTAAGT
5' ss Score
8
Exon sequences
Seq C1 exon
GCAAGGAATTGAGACGCGCTCCAGTTCGCTAGACAGTGACGGGGAGTACGAGGGTCCGCCCATATTACGCACCATTTCGCACGACGATCAAACCACAACACAAACTACTCCGGGAGCAATTCGCAAG
Seq A exon
AACTTAGTTTCGGCGATACTT
Seq C2 exon
GTTTGTGGAAATGCGCGCGGTGCTAAAATACGTTCCATACTTAGCTCAATTATTCAAAGTGAGACTATCTACGTGGAATGCCTCAATAAAATGATGCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0025836_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.741 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
PF0062115=RhoGEF=PU(10.9=60.6)
Main Inclusion Isoform:
FBpp0309061
Main Skipping Isoform:
FBpp0291410
Other Inclusion Isoforms:
FBpp0111832, FBpp0111833, FBpp0309060
Other Skipping Isoforms:
FBpp0309062
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCGCCCATATTACGCACCATT
R:
GAACGTATTTTAGCACCGCGC
Band lengths:
107-128
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)