Special

DmeEX0009771 @ dm6

Exon Skipping

Gene
Description
The gene silver is referred to in FlyBase by the symbol Dmelsvr (CG4122, FBgn0004648). It is a protein_coding_gene from Dmel. It has 12 annotated transcripts and 12 polypeptides (7 unique). Gene sequence location is X:496446..509072. Its molecular function is described by: metallocarboxypeptidase activity; zinc ion binding; carboxypeptidase activity; serine-type carboxypeptidase activity. It is involved in the biological process described with 6 unique terms, many of which group under: metabolic process; developmental process; negative regulation of phosphate metabolic process; regulation of organelle organization; post-embryonic animal organ morphogenesis. 79 alleles are reported. The phenotypes of these alleles manifest in: anatomical group; sensillum; eo-type sensillum; crossvein; adult sensillum. The phenotypic classes of alleles include: lethal; increased mortality during development; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chrX:496446-502220:+
Coord C1 exon
chrX:496446-497389
Coord A exon
chrX:499849-500608
Coord C2 exon
chrX:501985-502220
Length
760 bp
Sequences
Splice sites
3' ss Seq
TTTGTCTTCGCCATATTTAGGGG
3' ss Score
8.01
5' ss Seq
CAGGTAAAG
5' ss Score
9.65
Exon sequences
Seq C1 exon
CGTGTACAGAAACTGCGAGCGCTCCGGGAGAGTCCCCGAGAATCCCCAAAATGTTGTTTTTCTGCCTAGCCTTGATCATCGGCTGCGCAGTCGGAGAATACAGCGAAGTCCGGGTCATCCAGGAAGAGGACAACTTCCTGGAGAGTCCTCACTACCTAAAAAACGAGGAAATAGGAGATCTTTTCAGCCAGCTAGCCAAGGATTACCCCGACTTGGCGCAGACCTATACAATAGGCAAATCCCTGGAGGATCGACCCATCTACGCCCTAGCCTTAAGTGCACCTACCGGGGAGTCCAAGAATGGAGATCTCCTAAGGCCAATGGTTAAACTGGTGGCCAACATACAAGGCGATGAAGCCGTGGGTCGTCAGATGGTTCTCTATATGGCCGAATACCTGGCCACCCACTACGATGGGGACCCGAAGGTCCAGGCGCTACTAAATCTCACCGAAATCCACTTCCTGCCCACCTGTAACCCCGATGGATTCGCCAAAGCCAAG
Seq A exon
GGGACGATACTCTTCAATTTCCCCACTGTGCGCGGCGACTGAGGCAGCGGCAGCGGCGGCGGCAGAGGCGGGCGAATGGGCGCTTAAGGCCAATCAACGCAGCAAATTTTCAAACAGTTGACTTTTCGAGCCTGAGCTGCAACGACGACCCACGACGAACGGAGGCCCGACGGACATATAAGAAGAGAGCGAGTTGTGTGCGGGAGAGAGCTGAGAAGAAGCGGAGGAAAAATAACTGTTTCTCGCTCAATTCGCACGCCAGTGATAAAAACAACATAATCTCGACAAGATTGCAAATCGCAAGATGCCAACTCTGGGTCTCCTGTTCGCCTCCATCGGCATTGCCGTGCTGGCGATGGGTGTGCCGCATTGCAGGGGCTACACCATCAAGGAGGACGAATCCTTCCTGCAGCAACCGCACTATGCTAGCCAAGAGCAGCTGGAGGACCTGTTTGCTGGCCTGGAGAAGGCGTACCCCAATCAGGCCAAAGTCCACTTCCTTGGTCGATCTCTAGAAGGACGAAATCTGCTCGCCCTGCAAATCTCGCGGAACACCCGGTCGCGGAATCTCCTTACACCTCCAGTAAAGTACATAGCCAATATGCATGGAGACGAAACGGTGGGCAGGCAGCTCCTTGTTTATATGGCACAATATCTGCTCGGTAATCACGAAAGAATCAGCGACCTGGGCCAGCTGGTCAACAGCACCGATATCTACTTGGTGCCCACGATGAATCCAGATGGCTATGCGTTGTCCCAG
Seq C2 exon
GAAGGCAACTGCGAGTCGCTGCCCAACTATGTGGGTCGTGGCAATGCGGCCAACATCGATTTGAATCGCGATTTCCCCGATCGCCTGGAGCAGAGCCATGTCCACCAGTTGCGCGCCCAGTCTCGTCAGCCGGAAACAGCAGCCCTGGTAAATTGGATCGTTAGCAAACCGTTTGTGCTCTCCGCCAATTTCCATGGCGGAGCTGTTGTGGCCAGCTATCCCTATGACAACTCCTT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004648_CASSETTE1
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref, Alt. ATG (>10 exons))

No structure available
Features
Disorder rate (Iupred):
  C1=0.005 A=0.013 C2=0.177
Domain overlap (PFAM):

C1:
PF0024619=Peptidase_M14=PU(38.2=72.7)
A:
PF0024619=Peptidase_M14=PU(37.6=69.7)
C2:
PF0024619=Peptidase_M14=PU(44.3=97.5)


Main Inclusion Isoform:
FBpp0089126


Main Skipping Isoform:
FBpp0288455


Other Inclusion Isoforms:
FBpp0070080, FBpp0089125, FBpp0288456, FBpp0311069, FBpp0311070, FBpp0311071


Other Skipping Isoforms:
FBpp0089123, FBpp0089124, FBpp0309132
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAAGGATTACCCCGACTTGGC
R:
TTGCCACGACCCACATAGTTG
Band lengths:
348-1108
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)