DmeEX0010171 @ dm6
Exon Skipping
Gene
FBgn0265434 | zip
Description
The gene zipper is referred to in FlyBase by the symbol Dmelzip (CG15792, FBgn0265434). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (7 unique). Gene sequence location is 2R:24990570..25011965. Its molecular function is described by: actin filament binding; protein binding; ATP binding; motor activity; myosin light chain binding. It is involved in the biological process described with 28 unique terms, many of which group under: open tracheal system development; midgut development; gland development; wound healing; cellular response to external stimulus. 63 alleles are reported. The phenotypes of these alleles manifest in: photoreceptor; somatic precursor cell; filamentous actin; actin-based cell projection; denticle. The phenotypic classes of alleles include: some die during larval stage; wound healing defective; increased mortality; phenotype.
Coordinates
chr2R:24990948-24991973:-
Coord C1 exon
chr2R:24991810-24991973
Coord A exon
chr2R:24991565-24991698
Coord C2 exon
chr2R:24990948-24991272
Length
134 bp
Sequences
Splice sites
3' ss Seq
AAATTTATCTTTGGTTTAAGCTC
3' ss Score
5.1
5' ss Seq
GCTGTAAGT
5' ss Score
8.56
Exon sequences
Seq C1 exon
CTGAATAGCCGCATTAAACTGCTCAAGCGCAACTTGGACGAGACCGAAGAGGAATTGCAGAAGGAGAAGACGCAGAAGCGCAAATACCAGCGTGAGTGCGAGGACATGATTGAATCGCAGGAAGCCATGAATCGTGAGATAAACTCACTTAAAACGAAACTACG
Seq A exon
CTCCATACAAGTAGCCGAGACTGAAAAGGCCAAGGCATATTCGCCAAAAAAGGATGCCGCACTCATTATGAATTGTGAGGGTCTGCATTAGGTTTCGTTTCGCTTCGATTCGCTTCGTTTCCTTCTCGTAGGCT
Seq C2 exon
ACGCACCGGCGGCATTGGTCTCAGCTCCAGTCGGCTCACGGGTACACCTTCATCAAAGCGTGCAGGAGGAGGCGGTGGCGGCGACGACTCATCGGTCCAGGATGAATCATTAGATGGAGAGGATTCTGCCAATTGACGCGTTAATTATTAGATGAAGAAAAAGTTGAATCGCAGGAAGAAGGTGATGATGAAGAGCAAAATAAACGATTATATTTAATGTTTCTTTTATATAATTTCTCTGTTATTTTTTATATAAACTATTATACATACTTAAATTAAAACGTAAACGAAAAAACCAACATTTTTATAACGACAAAACTTAAAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265434_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (Iupred):
C1=0.989 A=0.600 C2=1.000
Domain overlap (PFAM):
C1:
PF0157614=Myosin_tail_1=FE(6.3=100)
A:
PF0157614=Myosin_tail_1=PD(0.1=3.2)
C2:
PF0157614=Myosin_tail_1=PD(0.1=2.2)
Main Inclusion Isoform:
FBpp0291731
Main Skipping Isoform:
FBpp0072306
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0072305, FBpp0099894, FBpp0099896, FBpp0291728, FBpp0291729, FBpp0291730, FBpp0297531
Associated events
Conservation
Human
(hg19)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGCATTAAACTGCTCAAGCGC
R:
ATCCTGGACCGATGAGTCGTC
Band lengths:
258-392
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)