Special

DmeEX6005412 @ dm6

Exon Skipping

Gene
FBgn0002938 | ninaC
Description
The gene neither inactivation nor afterpotential C is referred to in FlyBase by the symbol Dmel inaC (CG5125, FBgn0002938). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (2 unique). Gene sequence location is 2L:7377702..7384344. Its molecular function is described by 6 unique terms, many of which group under: binding; protein binding; catalytic activity, acting on a protein; hydrolase activity; calmodulin binding. It is involved in the biological process described with 13 unique terms, many of which group under: regulation of response to external stimulus; protein localization to rhabdomere; metabolic process; retina homeostasis; cellular component organization. 64 alleles are reported. The phenotypes of these alleles manifest in: anatomical structure; somatic cell; abdomen; cellular anatomical entity; anatomical cluster. The phenotypic classes of alleles include: visual behavior defective; wild-type; neurophysiology defective; phototaxis defective; viable; behavior defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed during late pupal stages, in stages of adults of both sexes.
Coordinates
chr2L:7382122-7383426:+
Coord C1 exon
chr2L:7382122-7382175
Coord A exon
chr2L:7382758-7382945
Coord C2 exon
chr2L:7383011-7383426
Length
188 bp
Sequences
Splice sites
3' ss Seq
CCGTTTCCATTTTCCCACAGCCT
3' ss Score
10.26
5' ss Seq
CAGGTGAGT
5' ss Score
10.67
Exon sequences
Seq C1 exon
TGGGCAAAAAGGGACCGGAGCATCATGATGTGGCCGCGTCCAAAATACAAAAAG
Seq A exon
CCTTCAGGGGATTCCGCGACCGCGTCCGCCTCCCTCCGCTGGTCAACGAGAAGTCCGGCCAACTAAACGAGAACACCGCCGACTTTATCCGTCCGTTTGCCAAGAAATGGCGCGAGAAGTCTATCTTCCAGGTCCTCCTGCACTACCGCGCGGCTCGCTTCCAGGACTTTGTCAATCTCTCACAGCAG
Seq C2 exon
GTCCACATCTACAACCAACGAATGGTGGCTGGCTTGAATAAATGTACTCGGGCTGTGCCCTTCGAGAGGATCAATATGCGCGAAGTGAACTCCTCGCAGCTAGGACCACTGCCAGTGCCCATAAAAAAGATGCCATTCCGCCTGGATCAGATACCCTTCTATGACACCCAGTATATGGTGGACCCGGCCAATTCCATTTCCCGCCAAGCCTTCCCCAATCAGCTACTAACGCAGCACATGGAGGACGATGAGCCTTGGGACAGCCCTCTGCAACGCAATCCTTCGATGACTTCTTGTGCCCTGACCTACAATGCCTATAAGAAGGAGCAGGCTTGCCAGACCAACTGGGATCGCATGGGCGAGAGCGACAATATCTACAATCAGGGCTACTTCCGAGATCCCCAACAGCTGAGGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0002938-'11-12,'11-11,15-12=AN
Average complexity
A_C1
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.077 A=0.016 C2=0.324
Domain overlap (PFAM):

C1:
NO
A:
NO
C2:
NO


Main Inclusion Isoform:
FBpp0079064


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0079065


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAAAAAGGGACCGGAGCATCA
R:
ATTGGCCGGGTCCACCATATA
Band lengths:
242-430
Functional annotations
There are 1 annotated functions for this event
PMID: 7556088
This event
Partially encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI001897; ELM sequence: DVAASKIQKAFRGFRDRVR; Overlap: PARTIAL_LEFT


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)