DmeEX6005413 @ dm6
Exon Skipping
Gene
FBgn0002938 | ninaC
Description
The gene neither inactivation nor afterpotential C is referred to in FlyBase by the symbol Dmel
inaC (CG5125, FBgn0002938). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (2 unique). Gene sequence location is 2L:7377702..7384344. Its molecular function is described by 6 unique terms, many of which group under: binding; protein binding; catalytic activity, acting on a protein; hydrolase activity; calmodulin binding. It is involved in the biological process described with 13 unique terms, many of which group under: regulation of response to external stimulus; protein localization to rhabdomere; metabolic process; retina homeostasis; cellular component organization. 64 alleles are reported. The phenotypes of these alleles manifest in: anatomical structure; somatic cell; abdomen; cellular anatomical entity; anatomical cluster. The phenotypic classes of alleles include: visual behavior defective; wild-type; neurophysiology defective; phototaxis defective; viable; behavior defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed during late pupal stages, in stages of adults of both sexes.
Coordinates
chr2L:7381756-7382175:+
Coord C1 exon
chr2L:7381756-7381905
Coord A exon
chr2L:7381961-7382058
Coord C2 exon
chr2L:7382122-7382175
Length
98 bp
Sequences
Splice sites
3' ss Seq
GTACTATCAATTGCTTTCAGATT
3' ss Score
7.37
5' ss Seq
AATGTAAGA
5' ss Score
5.55
Exon sequences
Seq C1 exon
ATACCAATTCCTTGCCTTTGACTTTGATGAGCCCGTGGAAATGACCAAGGATAACTGTCGTCTATTATTCTTGCGCCTCAAGATGGAAGGCTGGGCCTTGGGCAAGACCAAGGTGTTTTTGCGCTACTATAACGATGAGTTCTTAGCCAG
Seq A exon
ATTGTATGAGCTGCAGGTGAAGAAGGTCATCAAAGTGCAGTCCATGATGCGAGCTTTGCTAGCACGGAAACGAGTTAAGGGCGGCAAAGTTTTCAAAT
Seq C2 exon
TGGGCAAAAAGGGACCGGAGCATCATGATGTGGCCGCGTCCAAAATACAAAAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0002938-'9-9,'9-8,10-9=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.077
Domain overlap (PFAM):
C1:
PF0006316=Myosin_head=PD(6.0=80.4)
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0079064

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0079065, FBpp0306863, FBpp0306864
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTGACTTTGATGAGCCCGTGG
R:
TATTTTGGACGCGGCCACATC
Band lengths:
180-278
Functional annotations
There are 1 annotated functions for this event
PMID: 7556088
This event
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: . ELM ID: ELMI001896; ELM sequence: VKKVIKVQSMMRALLARKRV; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)