DmeEX6007780 @ dm6
Exon Skipping
Gene
FBgn0010309 | pigeon
Description
The gene pigeon is referred to in FlyBase by the symbol Dmelpigeon (CG10739, FBgn0010309). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2L:19186043..19189938. Its molecular function is unknown. It is involved in the biological process described with: positive regulation of amyloid-beta formation. 10 alleles are reported. The phenotype of these alleles manifest in: synapse. The phenotypic classes of alleles include: memory defective; learning defective; viable; neuroanatomy defective; partially lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
Coordinates
chr2L:19187079-19188805:+
Coord C1 exon
chr2L:19187079-19188242
Coord A exon
chr2L:19188299-19188531
Coord C2 exon
chr2L:19188591-19188805
Length
233 bp
Sequences
Splice sites
3' ss Seq
TAAAGCTACGAAATTTACAGTAT
3' ss Score
0.15
5' ss Seq
GATGTGAGT
5' ss Score
7.77
Exon sequences
Seq C1 exon
TGAAGGAGGCTCTTGTGGCTGGCAGCTATGCGGCTGCTGTTCGCGGACTACCAGAGGATGCCAAGCCACTGATGCGACTACTGCCATTGACTACTGCCTTAGCCTCGCGACCAATCCACGCAAAGGTGGCCGATATAAGCGTGGGTCTCTCTCATGAAACCCTGCACAATACCAGCATGATGCTGCTCTCGCCACAGCAGCGCCTTTCACCTTATCGCACGGACATCTGGACTCGCTTATGGGACCTTCTCAACGAGTCAGCCAAGCAGGAGCAGCCTAGATTCAGTGCTGAGCAGGTGACGGAGAAGTTGATCTTTAGTTTGGCCTGCTACCAGCCGGAGGCTCTGTCCAGATGCACCACGCCACTTTCGCCAGACACGGGCACCGGTGGATTTGGTGACTATAGTAGCGGAAGTGCTTTTCCATTCAGCAACGAAGTGCTGCCCTTTATCGAACTGGAGGGATGCACAGCCAGCAAGCAGGAGCACGTCATTTCTGTG
Seq A exon
TATCTGCGCGAGCTGAGCGTTCACCTGGTGAAGCACACGTCAAAGCCCAACACTGGCTTCCGCTGGCTGAAGGAGACCTTTTTCGAGCGCTCCCAGGCTCCAGCTCATGTGCATGCGGTGGCCTCCCAGTTCGTTTCCGCGCAGCTTGAACTCTCGCGGGCTCTTTGCTCTCTGGTTTGTCGTGCTGCAGGCCTAGATGCGCGCATGGAGACCTCGAGGGGTTTTCAGTTGAT
Seq C2 exon
TGACCAAATGGCTGCCAATCAACAGCACTCTCTGTTTCTAATCCTCGAGCGCTATTGCCTGGCTGTGGAATCGATTGCGTTTCCCCTGCCCGAGGGTTTCTCCTCGTTCTTCACCTACTTGGGCTATCGTGCGCTGGGCTATGATATGTTTCTGCAGTATGTGGAAAATCATGTGTTCGAACTGCAAGTGGATGTGATGAAGGCCATTGTTTTCG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0010309-'5-4,'5-3,6-4=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.057 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF149591=GSAP-16=PU(25.4=37.2)
C2:
PF149591=GSAP-16=FE(63.2=100)
Main Inclusion Isoform:
FBpp0080735
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0291717
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGAGCAGCCTAGATTCAGTGC
R:
ATTCCACAGCCAGGCAATAGC
Band lengths:
303-536
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)