DmeEX6011794 @ dm6
Exon Skipping
Gene
FBgn0265297 | pAbp
Description
The gene poly(A) binding protein is referred to in FlyBase by the symbol DmelpAbp (CG5119, FBgn0265297). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (1 unique). Gene sequence location is 2R:18140078..18147191. Its molecular function is described by 6 unique terms, many of which group under: organic cyclic compound binding; binding; heterocyclic compound binding; nucleic acid binding; RNA binding. It is involved in the biological process described with 12 unique terms, many of which group under: regulation of cellular macromolecule biosynthetic process; chemical synaptic transmission; compound eye photoreceptor development; cellular aromatic compound metabolic process; cytokinesis. 26 alleles are reported. The phenotypes of these alleles manifest in: ganglion mother cell; sarcomere; neuromuscular junction; adult thorax; cellular process. The phenotypic classes of alleles include: sterile; cell cycle defective; increased mortality; phenotype.
Coordinates
chr2R:18141488-18145274:+
Coord C1 exon
chr2R:18141488-18141672
Coord A exon
chr2R:18143413-18144897
Coord C2 exon
chr2R:18144967-18145274
Length
1485 bp
Sequences
Splice sites
3' ss Seq
TTCCCGATTTTCATCAACAGCTG
3' ss Score
8.72
5' ss Seq
AGAGTAAGT
5' ss Score
9.35
Exon sequences
Seq C1 exon
GTAGACCTGATCACCAAATATGGCTTCTCTATACGTCGGTGATCTCCCACAGGACGTCAACGAATCGGGACTTTTTGACAAGTTCTCGTCTGCTGGTCCAGTGCTGTCCATTCGTGTCTGCCGCGATGTGATTACCCGTCGCTCGTTGGGCTATGCCTACGTCAACTTCCAGCAGCCAGCCGATG
Seq A exon
CTGAGCGTGCTTTGGACACCATGAACTTTGACCTGGTTCGCAACAAGCCCATTCGCATTATGTGGTCTCAGCGTGATCCTTCTCTTCGTCGCTCAGGTGTGGGCAACGTGTTCATCAAGAACTTAGATAGGGCCATCGACAACAAGGCAATCTACGACACTTTCTCCGCCTTCGGCAACATTTTAAGCTGCAAGGTAGCCACCGATGAAAAGGGCAACTCAAAGGGCTATGGATTCGTCCACTTCGAGACCGAGGAGGCCGCAAACACGTCCATCGACAAAGTCAATGGCATGTTGCTCAACGGCAAGAAGGTCTACGTGGGTAAGTTCATCCCGCGCAAGGAGCGCGAGAAGGAGCTGGGCGAGAAGGCTAAGCTCTTCACCAATGTATATGTGAAGAACTTCACTGAGGATTTCGACGATGAAAAACTGAAGGAATTCTTTGAGCCCTACGGCAAGATAACCAGCTACAAGGTCATGTCCAAGGAGGATGGCAAGAGCAAGGGCTTCGGATTCGTTGCATTCGAGACAACAGAGGCTGCTGAGGCGGCCGTTCAGGCTCTCAATGGCAAGGACATGGGAGAGGGCAAGTCCCTGTACGTGGCTCGTGCCCAGAAGAAGGCCGAACGCCAGCAGGAGCTGAAGCGCAAGTTCGAGGAACTGAAGCAGAAGCGTCACGAGTCTGTGTTCGGCGTTAACTTGTACGTTAAGAACCTGGACGACACAATCGATGACGATCGTCTGCGCATCGCGTTCTCTCCATACGGCAACATCACATCGGCCAAGGTCATGACCGATGAGGAGGGTCGCTCCAAGGGATTCGGCTTCGTGTGCTTCAATGCCGCAAGCGAGGCTACCTGCGCCGTCACCGAGCTGAACGGTCGCGTCGTCGGCAGTAAGCCGTTGTACGTTGCTTTGGCCCAAAGGAAGGAGGAGCGCAAGGCTCATCTCGCCTCGCAGTACATGCGTCACATGACCGGCATGCGTATGCAGCAGCTGGGACAGATCTACCAGCCCAACGCGGCTAGCGGCTTCTTTGTGCCGACCCTTCCGTCAAATCAGCGTTTCTTCGGTTCCCAGGTGGCCACTCAGATGAGAAACACACCCCGCTGGGTGCCCCAGGTGCGTCCCCCAGCAGCCATACAGGGTGTCCAGGCCGGAGCTGCCGCTGCTGGTGGCTTCCAGGGCACAGCCGGTGCGGTGCCCACTCAGTTCCGTTCGGCTGCTGCTGGCGCTCGCGGGGCACAGCCTCAGGTGCAGGGCACACATGCCGCCGCTGCTGCGGCTAACAACATGCGCAACACTGGAGCACGCGCTATTACTGGCCAGCAAACTGCAGCACCCAACATGCAGATCCCCGGAGCCCAAATCGCTGGCGGTGCCCAGCAGCGTACTTCCAACTATAAGTACACCTCAAACATGCGCAATCCTCCAGTGCCACAGTTGCATCAGACCCAGCCAATTCCACAGCAATTGCAAGGAAAGA
Seq C2 exon
ATTCTGAGAAGCTCATTGCCTCGTTGCTGGCCAACGCCAAGCCGCAGGAGCAGAAACAGATCCTGGGCGAGCGTCTGTATCCGATGATTGAGCATATGCACGCCAATTTGGCTGGTAAGATCACCGGCATGTTGTTGGAGATCGAAAACTCTGAGCTCTTGCACATGATCGAGGATCAGGAGGCCCTTAAGGCCAAGGTGGAGGAGGCTGTGGCCGTGCTTCAGGTGCACCGCGTCACCGAGCCCGCCAACTAAGCTCGAACAGCTCAAGCGTATGAACATTTTACAAGAACACTTTACACCCAAAAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265297-'3-7,'3-5,6-7=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.284 C2=0.190
Domain overlap (PFAM):
C1:
PF0007617=RRM_1=PU(73.2=92.9)
A:
PF0007617=RRM_1=PD(25.4=3.6),PF0007617=RRM_1=WD(100=14.1),PF0007617=RRM_1=WD(100=13.9),PF0007617=RRM_1=WD(100=14.1)
C2:
PF0065813=PABP=WD(100=84.7)
Main Inclusion Isoform:
FBpp0085915
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0085917, FBpp0085919
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TACGTCGGTGATCTCCCACAG
R:
TTAAGGGCCTCCTGATCCTCG
Band lengths:
344-1829
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)