DmeINT0000622 @ dm6
Intron Retention
Gene
FBgn0022709 | Adk1
Description
The gene Adenylate kinase 1 is referred to in FlyBase by the symbol DmelAk1 (CG17146, FBgn0022709). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3L:12200322..12204082. Its molecular function is described by: ATP binding; adenylate kinase activity; uridylate kinase activity. It is involved in the biological process described with 6 unique terms, many of which group under: purine-containing compound metabolic process; ATP metabolic process; pyrimidine-containing compound metabolic process; organonitrogen compound biosynthetic process; nucleoside diphosphate phosphorylation. 11 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: viable; pain response defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.
Coordinates
chr3L:12201374-12203935:-
Coord C1 exon
chr3L:12203719-12203935
Coord A exon
chr3L:12201497-12203718
Coord C2 exon
chr3L:12201374-12201496
Length
2222 bp
Sequences
Splice sites
5' ss Seq
ATGGTGAGT
5' ss Score
10.13
3' ss Seq
CTCAAATCTTGTCCTTACAGGCT
3' ss Score
8.57
Exon sequences
Seq C1 exon
ATTCACTCAGTCACTCTCAACTCACGCAGCACAGAGGGTGGGTGGAAAACAGTCGGGCGGAGCATTCGAGAATCTGGGCGAGAATCGACCGACCAAGTGGCGCTAAGGGAAGGCTAGTAAGGCATCCGGCTAACAAACTACCGAATATTTCGCGATTTCTTCAGCGAAAGGCCCGCAGCAGCGACGTGTATATCTAGTATACATCATCATCATCATG
Seq A exon
GTGAGTGTTTTCAGTGCGCGGTTGCTGTGATTTGTGTTTTCGTTTCTGCTTAATGCCCAATTTATTTTTATTTGTTTGTAACCCACACACACACACCCCAAATGTTTCACTCTGATTTAAAACGGCCTTGCACTCCAACGGGGGAAAGTGAAGCAATGGCTTTAAAATTGAGGATTCAGAGCGGTCAAATCGGCCTTGAGCCACTTGCATTGCACTTGACCTTGCAGCCCAGCGTTGCAATTAAGAAAGTTTCGGGGCCACAAGCTTACTCAGCTTTTTTTTTTTTTTTTGAAGCTGAGAATGGGGTATGAGATGAGAATGAGAATGAGAAGCTCCCGGTCAGCTGTTCCATGTTTACGGTTTTGTTATAAATAGAGCCTCTCCTAATTCCAACGATTACGAATCTGTGAAATTCCCTACCCGAACAAAACAAATTAGCAACTGAAAGAAACAAACAAACAAAAAATAAATACCAAAATTTCACATTCCAAGCTCGAACAAACGAATTTTGACGTCAAAATCCCGATTTGAATAAATTTATGACCAGTTGCTCGGCACACAGGAATTTCTGGCGGGGCTTGATTCATTAGCAAGTCCCCAGCCTCGTCGCCAAAAAAAGCAGTTTAAATGTGTTTATTGGCGCTACTCGAACTAGACAGTCATGCCGGTTTTTAGTCTTGGTCGCGTCGCATTATTAAAGTGTCAAAACAAAGCAAAAAAATTAAAAAGAACACCATATAAAAGATCTAGAGGCGGGTTCCATAAAAATTCCTCTAAGTTTGCTGGATAGTTTTTTAGTTCCGTTTGAACGGAAAGCATGTGTGCAGTTCTTCCTAGAAAATTATAGTTATAGTTAGTTCTAAAAATAAACAAAGGAAAATCATCCTAAAAATACATATATCGAAATCAAAAGCCGAGTTTCGTAAAAATCCACGTGAGTTAGCTAGCTGAATAGTTTGAATAGAAAGCACTTGTGATGTCGCTGCTATAATTTTCTATAATTACCCTTAAGTATTTGGGAACCTCGACACTTGTTAAATCACCATGTACAGGTTAGTTTTGAATTATTAACAACGGCGAATCCTTGGAAATGACATTGAAAAGTCACTGAACTACACAATCTATATAAATGTGAAGAGAAATTACGTAAATGAGCTTGAAAATCATAAATTCTCACACGCAACAATTTAAATGCGTAGAAATGTGCCATAAGAAAAGTCGGTGAAAAACAACGTCTGCGTTTTTATGCTCTGAGGAAAATCGAAAAATCTATAGGTGCCAGGCAGCAAACAACCTGGGCATTATTAAGCTGTCCGAATCCGAATTCATTCATTTTCTATATTGTATTTTCATTTTTTTTTTTACCCCATTTTTCGACGGGTGCGACAATGCGGAACAGGCGAAAATCGGCGGGGGCCTTCAAAATACAAAATACTATATCAAAAGCTGATCTGCACACACGCTATATCTATCTATCTATATGGTCACGGGCCGACAACGGGAGCGATGGCATTGTTTATACTAATCTAGATTTTTGTTGATGAGATCAAGCCATTATCAATACCATTTGTGTGAATGGAGCAGAGGTGCCAATTGCCCCAAATTACCCCAAATTGAAATGATATGTGTGACGCGGGGGTTTTCTGTACAAGATCAATGTCAGGGGCCAATGAAATATGTGTAACCTATATATATATAAAATCCCATTTTTGTAGTAAGAACACTATTTCGTGCTGGCAAAGTGCCCAAACTACTAATAACTACATATTAACCTATGCCAAAATACATCTCGGATGTAGTTCAAACTATAAGTCGGAGATATCTAACCATCCTCACCAACTATCTCGATTGTGTAGTTATTTATGTGTCACCAAAGGGTTATGAAGAAGGAGGCCGAGGAGAAGCTCAAAGCCGAGGAGCTCCGTAGGGCACGTGCCGCCGTAAGTAGCCCAACTGGATCGAATCCGAGTCAACGGGCACTATATCCTATTTACTAGGATTAGTTGATGTATGGCATGTTAACTGTCTGGCCGCCGCTTCACCAAAAAACAAACGAATTTCGATCCGAGAATATTGAAAAAAATAAACCCTCTTTTGAAACCCTCTATCCATGCCCCTTAATCCAACTAAGCTTGCGTACGTGTTACCACTAAACCAGCTAATTGTAGATGTTCCTATGCCTCGGTGTTGTGTGCCTGCTAACTCAAATCTTGTCCTTACAG
Seq C2 exon
GCTGATATACCCATCATCTGGATCTTGGGTGGACCCGGGTGCGGCAAGGGCACTCAGTGCGCCAAAATCGTGGAAAAATACGGATTCACACATCTGAGCAGCGGCGATTTGCTGCGCAATGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0022709:FBtr0076017:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0040617=ADK=PU(20.8=80.5)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0075749
Other Inclusion Isoforms:
FBpp0075750
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)