DmeINT0018925 @ dm6
Intron Retention
Gene
FBgn0024806 | DIP2
Description
The gene DISCO Interacting Protein 2 is referred to in FlyBase by the symbol DmelDIP2 (CG7020, FBgn0024806). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (5 unique). Gene sequence location is 3L:250229..257954. Its molecular function is described by: catalytic activity; protein binding. The biological processes in which it is involved are not known. 13 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: viable; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr3L:253314-255037:-
Coord C1 exon
chr3L:254697-255037
Coord A exon
chr3L:254637-254696
Coord C2 exon
chr3L:253314-254636
Length
60 bp
Sequences
Splice sites
5' ss Seq
TGGGTAAGT
5' ss Score
10.24
3' ss Seq
ATTATAAATCTGCTTTGCAGGTG
3' ss Score
8.38
Exon sequences
Seq C1 exon
TTTCATTACAGCCTGGTATGGTTGTATGTTTCGGGGCTTAGTACCCCTTCCAATAGAATTGCCGCTGTCTAGCTCGGATACTCCTCCGCAGCAAGTGGGATTCTTATTGAGTTCTTGTGGCATAACTGTAGCTCTTACCTCAGAAGCTTGCTTAAAAGGTCTTCCTAAATCAACCACCACGGGGGAAATAGCAAAATTAAAGGGCTGGCCGCGCTTGCAGTGGTTTGTGACTGAGCATTTACCTAAGCCGCCCAAAGAATTCAATGTTGGTAATTTACGGGCCGATGATTCGGCAGCAGCTTATATAGAATACACGACAGATAAGGAAGGCAGTGTTATGG
Seq A exon
GTAAGTGCAACATATATCAGCATCCAAATATTTATAAATAATTATAAATCTGCTTTGCAG
Seq C2 exon
GTGTCACTGTTACTCGCGCAGCGATGATTAATCATTGCCGTGCTTTGACTATGGCCTGCCATTATACCGAAGGCGAGACAATTGTATGTGTATTGGACTTCAAGCGTGAAGTTGGATTATGGCATTCGGTCTTGACATCCGTTCTAAATGGTATGCACGTTATTTTCATACCCTACGCATTAATGAAACTGCGTCCGTCGAGCTGGATGCAATTAATAACAAAACACCGAGCTTCTTGTTGCTTGGTTAAGAGTCGAGATCTACATTGGGGACTACTCGCTACTAAAGATCATAAGGATATATCGCTTTCCTCTCTACGTATGTTGCTTGTAGCCGATGGAGCCAACCCCTGGTCGTTATCCTCGTGTGACCAGTTCTTGAGTGTTTTTCAAGCTAAAGGATTACGCTCAGATGCGATTTGTCCATGTGCCAGTAGCTCCGAAGTATTTACTGTTTCCCTTCGGCGTCCTGGGCGAGGATCTTGTGGATTTAGTCCGTCAGCTACTGGACGTGGTGTGCTTTCAATGGCAGCACTATCGCATGGAGTTGTACGCGTTGACAGTGAAGACTCATTAACATCGCTCACTTTGCAGGACTGTGGTCAAGTTATGCCAGCTGCACAAATGGTGGTTGTTCGATCGGAAGGACCACCTGTGCTGTGCAAAACCGATCAAGTCGGCGAAATATGCGTTACTAGCGGATCCACAAGCGCCAGTTATTTTGGTCTCGACGGAATGACAAATTCAACATTCAAGGTTCAGCCTCTATTAGAAGAATTGGAACAACCAAAAGATGGAAATGGCACGGTGAACATTATTTCCAAACCAATTGGCGAAGACTTTTACGTTAGATCAGGTCTACTGGGCTTTCTTGGTCCGGGTGGCTTGGTCTTTGTGTGCGGGTCCCGTGATGGTCTGATGACCGTTACCGGTAGAAAGCACAATGCGGATGACATTATTGCCACAGTGTTAGCTGTGGAACCCATGCGGTTTATTTATCGAGGACGCATTGCTGTATTTAGCATTAAAGTTTTGCGCGACGAACGCGTGTGCGTCATTGCTGAACAACGTCCGGACTGCTCGGAGGAAGAAAGTTTCCAATGGATGTCACGTGTTCTGCAAGCAGTAGACTCCATTCACCAAGTCGGAATTTACTGCCTGGCATTGGTTCCGCCGAATCATTTGCCAAAGACTCCTCTTGGGGGCATACATTTATGCGAAGCACGGCGAAGGTTCTTGGAGGGATCTCTCCACCCAGCGAATGTTTTAATGTGCCCACATACATGTGTTACCAATCTACCAAAGCCACGGGAACTACATCAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0024806:FBtr0072520:7
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.009 A=NA C2=0.010
Domain overlap (PFAM):
C1:
PF0050123=AMP-binding=FE(23.2=100)
A:
NA
C2:
PF0050123=AMP-binding=PD(62.8=69.9)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0072420
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0293868, FBpp0304418, FBpp0304419, FBpp0304420
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGATGATTCGGCAGCAGCTTA
R:
CCTTCGGTATAATGGCAGGCC
Band lengths:
132-192
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)