DmeINT0019197 @ dm6
Intron Retention
Gene
FBgn0013810 | Dhc36C
Description
The gene Dynein heavy chain at 36C is referred to in FlyBase by the symbol DmelDhc36C (CG5526, FBgn0013810). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2L:17501401..17525515. Its molecular function is described by: ATP binding; dynein light intermediate chain binding; ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding. It is involved in the biological process described with: cilium movement; microtubule-based movement; sensory perception of sound. 9 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: neurophysiology defective; viable; auditory perception defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period, in adult male stages.
Coordinates
chr2L:17510562-17511608:+
Coord C1 exon
chr2L:17510562-17511348
Coord A exon
chr2L:17511349-17511425
Coord C2 exon
chr2L:17511426-17511608
Length
77 bp
Sequences
Splice sites
5' ss Seq
CAGGTGGGG
5' ss Score
6.92
3' ss Seq
ACTCTTTTAGACTCTTACAGATC
3' ss Score
4.66
Exon sequences
Seq C1 exon
GGGCTTTTCCAAGGAGTTCGATCCTTGTATTGACGAGATCGTAGGCGCCACCCTGACCATATACAATGACGCCAAATTGAATCTGCTCCCCACACCGGCTAAATCCCACTATCTCTTCAATCTGCGCGATTTCTCGAGGGTTATACAGGGTGTCCTGCTGTCCGTTCCCGAAGCAACTGAAGATGTCAACTCCATGAGGCGACTGTGGGTGCACGAGGTGTTGAGAGTGTATGGGGATCGATTGGTTGAAGATGCCGATCGCAGCTGGCTGTTTGAGAATATCTGCAGCACGGTGAAATCGTGCTTCAATACGGACCCCTCTCGCCTCTTCGGTCGCCTTGTGGAGAAGGACAAATCCCTGCAGGAGTCCGATTTCCGTCAGTTGATCTACTGTGACTTTACCAATCCCAAGGCGGATACCAAGAACTATGTGGAGGTGCAGGACCTGGAGGAGTTGCGCCGTGTGGTGGAGGCATATCTGGTGGAGTACAACAACATGTCGAAGAAACCCATGAATCTGGTGCTTTTCCGTTTCGCCATCGAGCATTTGTCGCGCATATGCCGCATCATAAAGCAGCCGAGGAGTCATGCTCTACTCATCGGGGTTGGTGGCTCCGGACGCCAGAGCTTGACTCGATTGGCTTCGCATATATGCGACTATGAGCTGTTCCAGGTGGAAATCACGCGATTGTATGGGCCGTACGAGTACCACGAGGACATCAAGGCGATCCTACGCAAAATTGGGGCATCCGAGATGCACGGCGTTTTCCTCTTTACGGACGTTCAG
Seq A exon
GTGGGGAACCGCAATTGGCAAATCCGACTGTGTCCTGGGCTTTCCTTGGTCTCGCTAACTCTTTTAGACTCTTACAG
Seq C2 exon
ATCAAAGATGAATCCTTCCTGGAGGACATTAGCAATTTACTGAACTCCGGTGAGGTGCCCAATCTCTTCACCAACGAGGAGAAGATCGAGGTGCAGGAGAAGATGGCCCAAATCGACAAGCAGAGAGATAAGGCCGTACAGACGGATGGCAGTCCAGTGGCGCTGTTTAACTTTTTTGTCACG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0013810:FBtr0304742:12
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.033
Domain overlap (PFAM):
C1:
PF127752=AAA_7=PD(26.5=27.4),PF127802=AAA_8=PU(36.4=37.6)
A:
NA
C2:
PF127802=AAA_8=FE(22.1=100)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0293284
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGATTGTATGGGCCGTACGAG
R:
CGTTGGTGAAGAGATTGGGCA
Band lengths:
178-255
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)