DmeINT0019218 @ dm6
Intron Retention
Gene
FBgn0013811 | Dhc62B
Description
The gene Dynein heavy chain at 62B is referred to in FlyBase by the symbol DmelDhc62B (CG15804, FBgn0013811). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 3L:1759172..1771758. Its molecular function is described by: ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding; ATP binding; dynein light intermediate chain binding. It is involved in the biological process described with: cilium movement; microtubule-based movement; retrograde axonal transport. 11 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: flight defective; fertile; lethal; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed in adult male stages.
Coordinates
chr3L:1765926-1766542:-
Coord C1 exon
chr3L:1766228-1766542
Coord A exon
chr3L:1766169-1766227
Coord C2 exon
chr3L:1765926-1766168
Length
59 bp
Sequences
Splice sites
5' ss Seq
CCCGTAAGA
5' ss Score
5.66
3' ss Seq
CCAAGGTTAATCAATTGCAGTGC
3' ss Score
2.31
Exon sequences
Seq C1 exon
GTCATCTTTGACGGACCGGTAGATGCCGTTTGGATTGAGAATATGAACACGGTGCTGGACGACAACAAAAAACTGTGCCTGACCAGCGGCGAGGTGATCACCATGAGCAACGAGATGTCGATGGTGTTCGAGGTAATGGACCTGGCTCAGGCCTCACCAGCCACCGTTTCCCGCTGTGGCATGATCTACATGGAGCCCTCGACGCTCGGCTGGCGCGCCTTTGCCAAAAGCTGGCTCAAGAAGGCCGATCCTCGATGGGCGGATGAGGAGGGCGTGCCCTACGTAATGGCCCTGATGCAGTGGCTTCTACCGCCC
Seq A exon
GTAAGAAATTCTTCTCAGCCTACGAAGCTCACCACCTGACCAAGGTTAATCAATTGCAG
Seq C2 exon
TGCCAGACCTTTGTACGGCGGTTCTGCAGCCAGTTTATCAAGCCAGGAGAGTTCAATTGTATGCTGACCACCTTCGACCTGTTCGACATGCAAATCGCGGAGGCGATCGAGGAGAATCCAGAGGACTACCAGAAGTACCTCCAGACATACTTCCAGGCGGCCATACTGTTCGCTCTGATTTGGGGAGTGGGTGGAGTGCTGGACACCGCTTCCCGGGAGAAGTTCGACGTGTTCTTAAAAAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0013811:FBtr0303106:4
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF077289=AAA_5=PD(39.5=55.2)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0292225
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCTACGTAATGGCCCTGATGC
R:
CGCGATTTGCATGTCGAACAG
Band lengths:
137-196
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)