DmeINT0019248 @ dm6
Intron Retention
Gene
FBgn0013812 | Dhc93AB
Description
The gene Dynein heavy chain at 93AB is referred to in FlyBase by the symbol DmelDhc93AB (CG3723, FBgn0013812). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3R:21024580..21042499. Its molecular function is described by: ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding; ATP binding; dynein light intermediate chain binding. It is involved in the biological process described with: microtubule-based movement; sensory perception of sound; cilium movement. 8 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: auditory perception defective; neurophysiology defective; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed in adult male stages.
Coordinates
chr3R:21028495-21029237:-
Coord C1 exon
chr3R:21028727-21029237
Coord A exon
chr3R:21028666-21028726
Coord C2 exon
chr3R:21028495-21028665
Length
61 bp
Sequences
Splice sites
5' ss Seq
AAGGTGGGT
5' ss Score
8.23
3' ss Seq
TATACTTCCTTCATTGGCAGGCT
3' ss Score
7.7
Exon sequences
Seq C1 exon
GGCTATTAAAATTGGAGACAAGGAGATCGAATACAACTCCAACTTCCGCCTGATCCTGCACACCAAGCTAGCTAATCCGCACTACAAGCCAGAGATGCAAGCACAAACCACACTTATTAACTTCACCGTAACACGCGATGGACTAGAGGATCAACTGCTGGCGGAAGTGGTGAAAGCAGAGCGTCCCGATCTGGAGGAGTTGAAAGCCGATCTCACAAAGCAACAAAACGATTTTAAGATCATGCTGAAGAAACTGGAGGACGATCTATTGTCGCGCCTTTCGTCGGCGGGTGAGAATATTTTAGGTGACACGGCGCTGGTGGAGAACCTGGAGACCACGAAGAGCACTGCCTCGGAGATCGAGCAGAAGGTGGCCGAGGCGAAGATTACCTCCAAGGAGATCGACAAGGCCCGAGAATATTACAGACCGGCGGCGGCCAGAGCCAGTTTGCTTTACTTCATCCTAAACGAACTAAACACTATCAATCCGATATATCAGTTTTCACTGAAG
Seq A exon
GTGGGTTATGAGGACTTCGAGTTTAGATAGCCTTATTATGATATACTTCCTTCATTGGCAG
Seq C2 exon
GCTTTTAGTGTAGTGTTCCAAAAGGCCATAGCCAAGGCTGAACCTGGCGATACTTTGGATTTGCGTGTCTCCAATCTGATTGATTGTATAACGTATTCGGTGTTTCAGTACACTTCGCGTGGTCTTTTCGAATGCGACAAGCTCATCTTCGCCTCGCAAATGACATTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0013812:FBtr0273236:21
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.018 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF127812=AAA_9=PD(53.1=70.8)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0307750
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0271744
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GAATATTACAGACCGGCGGCG
R:
GGTTCAGCCTTGGCTATGGC
Band lengths:
140-201
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)