DmeINT0019429 @ dm6
Intron Retention
Gene
FBgn0035538 | DopEcR
Description
The gene Dopamine/Ecdysteroid receptor is referred to in FlyBase by the symbol DmelDopEcR (CG18314, FBgn0035538). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (1 unique). Gene sequence location is 3L:4367649..4380387. Its molecular function is described by: dopamine neurotransmitter receptor activity, coupled via Gs; ecdysone binding; G protein-coupled amine receptor activity; G protein-coupled receptor activity. It is involved in the biological process described with 12 unique terms, many of which group under: response to external stimulus; response to stress; system process; response to chemical; response to sucrose. 21 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: behavior defective; learning defective; phenotype; mating defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during late pupal stages.
Coordinates
chr3L:4369826-4371904:-
Coord C1 exon
chr3L:4370598-4371904
Coord A exon
chr3L:4370085-4370597
Coord C2 exon
chr3L:4369826-4370084
Length
513 bp
Sequences
Splice sites
5' ss Seq
AGGGTACGT
5' ss Score
9.15
3' ss Seq
CGATATTGCTGTCATCGCAGGAC
3' ss Score
4.47
Exon sequences
Seq C1 exon
ATGCGCACAATTAGCTTAAAACGACAGCAGGACGTGGAGTTTAAACACCAACAACAGCAACAAGAGCCAGAATTTACAAGCAAAAGGATAATCACAATCACCAAGCAGCGAAATTAAATAGCAAAACCGATACTTAACAACCGAACTATTATCGAACTATTTTAACAAACTTAAATGTAGCACAACAGAAGCCTTACAAAACAACAAAACCATTTGTGCTGTGCTTTAATTATAGTCGAAAGATATTTCAACTAACCCCGAAAGAAAAAGAGCCCTGAAAACCGCGTAATTATTACACATTAAATAGTTAAATTAATAATCATTATTCTTCCACTTGCGAGTTTGAAATGTGTACATTTTTAAATCGATATTAAAACTAGTAGCGAATTATTCAAGCATACAACTAACAGTTTTGACGTTCATTAAAACTTAGCAAAGAGCGTTGTGAATTTAGCAAAACAAAACGAATTCTTTAAATCATTAACGATCCTCTAAGATAGAAACCAAATTGTACGCAATTACTAGATTTTACGTGTAAGATTTTAGCCCAAGCAGCATTTTAAACGAGCTTCAGACACACACATAGACACACACACACCAGCACAACCTTATCCTTAACCTTAACCACGACGCCAGGATTGTGAGGGTAACAATCAAATGCTTGGCTCGGCGCCAAAAGGTGGGCAGTAGTAGAAGTTGCAGCCCAAATAAAAGTAGGCAGTAGAAAATTTATACAAATTTGGCGCCAACGTTGGAGAAAGGACGAAAAAACAGCGCCAAGGACTCCGACGACCTTCGCGTGTGCAAGCCTCGTTGCACAATAAAGGACGCCACCAACACTCGCACCCAGACACACACACACACTCACACATCGACACACTCACCTAAGCACACATAGACACTCACAGACACACCGACACACACAACCGAAGGCACAGGACAATTGCATGGGCGTCCGCCATGACCGGAAGTAAAGTACGGTCACGTCCACGTCCACTGGCCTTTGCATAACAATCAGCCCGCCAAGAAGGTGCGGAGAAAGCGGGTGAAAGCAGCAGCGAAAGCAGGTGAAAGCAGGAGGAGCCAAGGAGGAGGGAAACGGACAAGGAGCTAAGGGAGCGTATACAACGAGCACAGGAGCGCCCATTTCAACCGACAGTGCCAGCCCGTAAAAATGCAGGAAATGAGCTACCTACAGGATAATTCCAAGGTGGAGGCCCTCACCAAGGCGGTGCTCATATCGATACTGGGCGTGGCCATCGTCCTGTCCAACCTCCTCATTATCGCCACCTATGCCAACTTCAAGG
Seq A exon
GTACGTTGCACGAATATCACACTCACATAACACTTTCCACAGGAACATCTCGAATCTCGCGGTTGGGTTTGGCCTCAAGCATAATATTTTCATAAGTAACCTACATATGTGTTGAATATAATTTATTTTGACCACTTAAGTCCAATGTTTATACTTAAAATGCATCCATGATTTTGATGTGAAAGTGAAAGGAATGAAGTAACACGGCATCCTCCCCAAAAATTCAAATGTGTTGTTTTCTTGTTGTCTTAATTGCTTTGAAAAAATTCAAAAACCAATTGTGCTTAAGCATATTATTTCTTTCCCCTTTTTGTACCTAAACTTTTATCCTATAAATTGATTGTTATTGGATAAATTTAAGAACCTTAGGTTTCTAAATAGTTCTAGTGAATGTCGTACAAATAGACTCGCCCAAATTATTGAATGATCCATTTAAATATTATTGTTTGCATTTGCCTATTATTTTTGAATACACCTCTACTTCGTTTTCTAACGATATTGCTGTCATCGCAG
Seq C2 exon
GACCCACAGAGGTGATCAACTACTACCTCTTGTCCCTGGCCATCGCCGATCTGCTCTGCGGACTCCTGGTGGTGCCCTTCTCCGTGTATCCCGCTTTGACCGGAGAATGGATGTACGGCGACATCGTGTGTCGCTTCACCGGCTATCTGGAGGTCACTCTGTGGGCGGTATCGGTATACACCTTCATGTGGATATCAGTGGATCGCTATCTTGCGGTGCGGAAGCCACTCAGATATGAAACGGTGCAGACGAAAACGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0035538:FBtr0073337:3
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0000116=7tm_1=PU(5.2=28.9)
A:
NA
C2:
PF0000116=7tm_1=FE(34.4=100)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0073193
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0099542, FBpp0099543
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAGGAGGAGGGAAACGGACAA
R:
GTCGCCGTACATCCATTCTCC
Band lengths:
344-857
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)