DmeINT0019879 @ dm6
Intron Retention
Gene
FBgn0004865 | Eip78C
Description
The gene Ecdysone-induced protein 78C is referred to in FlyBase by the symbol DmelEip78C (CG18023, FBgn0004865). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (2 unique). Gene sequence location is 3L:21226609..21266503. Its molecular function is described by: steroid hormone receptor activity; DNA-binding transcription factor activity; zinc ion binding; sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription, DNA-templated. 55 alleles are reported. The phenotypes of these alleles manifest in: anatomical structure; anterior-posterior subdivision of organism; organ system subdivision; cell; gonad. The phenotypic classes of alleles include: increased mortality during development; fertile; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages.
Coordinates
chr3L:21226919-21231112:+
Coord C1 exon
chr3L:21226919-21228391
Coord A exon
chr3L:21228392-21230879
Coord C2 exon
chr3L:21230880-21231112
Length
2488 bp
Sequences
Splice sites
5' ss Seq
AAGGTACGT
5' ss Score
10.75
3' ss Seq
AATGCAATTTTCCCTTGCAGAGC
3' ss Score
10.33
Exon sequences
Seq C1 exon
AAGCATTAACGAAAGAACTGCGCACAAAGTAGGGAGGCAATAATTACATATGTACATGGCTGGGAAAGGCCTTAACTAAACTTAGCAAACTAATAAATAGAAAAAAGGAAATATTGGCCAAATATTATAGTATTGGGAATATTAGGTTACTTGATATCAAAAATTAATGTCTATTTTATACACTTATTCTTAGACTTAATGTTAACTTATCGTACTTATTATGATTGGTTTTTCAAGATTACCAGAACTTGATAGATTGGTCTAGCTTTTGAAATCGGATAGCATTTTCTTTAAAGGACTTTGCCATATGCTAAAGCCTAACTTCTTTTTTCAATTCAGCCACAGCTGACAAAAGCGAAGAAAATTTGAAAGACCGTGAATCCTTTTGAAACGCCCTCTCCGGATTCCTCATTAAGTGCAAAAGATATAACATCGCAGAGATTTCCCATAAAAATGCTGATCAGGCGCCCTCGCAGGTTGCCAACGTCGATTTCCGCCAGCAGGACGATGATGAAGATGATGGATGCCCATCTCACCGATTCGATCCGAGCAACATGGATGTATACCAAATAGAGCTGGAGGAACAGGCACAAATCCGCTCCAAACTGCTGGTCGAAACCTGTGTGAAGCACTCGTCTTCGGAGCAGCAGCAGCTCCAAGTTAAGCAGGAGGACCTCATCAAGGATTTCACTCGGGACGAGGAGGAACAGCCAAGCGAAGAGGAGGCGGAGGAAGAGGACAACGAAGAGGACGAGGAAGAAGAAGGCGAAGAAGAAGAGGAGGACGAGGACGAGGAAGCCCTGCTGCCGGTAGTCAATTTTAATGCAAATTCAGACTTTAATTTGCATTTCTTTGACACACCGGAGGACTCGTCCACCCAAGGGGCCTACAGTGAGGCCAATAGCTTGGAATCCGAGCAGGAAGAGGAGAAGCAAACACAGCAGCATCAGCAGCAGAAGCAGCATCACCGGGATTTGGAGGATTGCCTAAGTGCCATTGAAGCTGATCCATTGCAGTTGTTGCATTGCGACGACTTCTATAGAACATCAGCCCTAGCAGAGAGTGTTGCAGCCAGTCTAAGCCCACAGCAGCAGCAGCAACGGCAGCACACCCACCAGCAACAACAGCAACAGCAGCAGCAGCAGCAACACCCTGGACAGCAGCAACATCAGCTCAACTGCACGCTGAGCAATGGTGGAGGTGCTTTGTACACCATCAGCAGTGTGCATCAGTTCGGTCCGGCCAGCAACCACAACACCAGCAGCAGCTCCCCCTCCTCCAGCGCCGCCCACTCTTCGCCGGACAGCGGCTGCTCGTCGGCCTCCTCCTCCGGATCTTCGCGATCCTGCGGATCCTCCTCTGCATCCTCCTCCTCGTCAGCGGTCAGCAGCACCATCAGCAGCGGCCGCAGCAGCAACAACAGCGTCGTCAACCCCGCAGCAACATCTTCATCTGTTGCGCATCTGAACAAAG
Seq A exon
GTACGTGCAATTTGCAACTGACACTGCGACTCTTCCGCGTTGTCGTCTCCTCTCCTCTGCTGCGGACCATTGTTGTCGGTCTTTGAAATTGTGTTCAATAAATTTGCATTCATTGCATAATAGCTGCAACAGCAATTGAAAGTCGTTGGGTCTTCGGTTTCTTCTCCTTTTGAGGAAACTATTAAAGCGCAGCATGGAAAATGTGAAAATGAATATAATTCGCTGTTATTGGCCAATGGCTGTTGCTGTTTCAGTTTTCTCTTTAGTGCGAGGAAATTGCTTTTCATGTTGCACGTCTGTCAATGTGCTTGCATTTGCCGCTGCATTTGCTTTTCCTTTTGGGTGCAGTGCAATTGAAAGCCATGGAAAAGATGTTTTAATTTTCATAAATCGCCTTGAATTGGTCTCGGCTCTCTTTTGCCTTGGATGATGGTATTTGAAGGGGCTAAGCCCATTCTACTCCTCCGGGAGTAGTTGGTGGCTCGAACGAATGGGTAGTTGGAACCGGAAATGCAACAAAACATAGGCTTAATAACTACTACGGTCAGCTGCTGCTTACACAGAGACTTTCAAAAAAAGAAACCAACATATATATTTTAAACAATTTTTTTTATAAATATCTAAATCCAATACATTTTTATTGCTGAATGATTTACCGCCACTAATAGCCAAGAAAATGATTATTTAACTTTAAATATAAATTTGTTTATTTTCAATAAATTTTATAATATTTTGAACTACAATTCGACATTATAAATACTATTCGGCTTGGCTGAACTTGCAAATTGCCTGGATTTTTTGGCGAAGATTTCATTTCGAGTCCTGGAATGGCAACATTTAATTGCGTCAATTAGTGCGAATGAAAATTAAATCTGTTAGGAAAGGCCTTGAAATCAAGCTGGGAATTAGAGGAAAAGTCAAAATCTCGACTGCTTTTTCCACGGCATTCAAATTGATATTCCTCTGCCGGGGCAAAAATTGACTGCAATCGCTCGTTGTCCACTCCACTCAATTAGTTGTCTTCAACCAGATAAATGCATGAAATGAAAATGGAAATGGGAAAAAGTCGAGGAAATATGAAGTCTTTGTCGTCTATCGTCCATGCCTCTGACTTGTCTGACAACGCGGAAATGCCAAGCAGTTTTCCACCAGCCAGTCAGCCAGCCAGCCAGCCAGCCAGTCAACCCACAACCCGCACCCCTTTTTCTTCGGCTGGATAAACAATGGCGTTTCAAATTGTCAACTTGCAAAAGCCACCAAATGATTTGCATTTGAACGCGGCGCGAAAATGAAAAGCAGCCACTTGAGTTTCCTTTGCGTTTTCTTTTCTTTTTCATTCCTGCCCGGGCCGACGACATTTTCCAGACGCCGTTGTTGTAGTTGTAATTGTTGTTGCACTCCAATTGTAAAAATTCAATTTGCAATTGCACAAGCGCGTAACGCGCCATCCACTGTAAGAAAAAACAAATGATGTAAACATGCATCACCAAAGTTGATCACCAAATAAATATTAACAAATTTAAACGGTTTCGGAAGTGATGTGTATTAGATTAATATTTGTTACAAAATTTGTAAAGGACAGTTTCTTGGACCAAGCACAAGGACATTTTATTACAAGAAATAAATTGAAGTTCTGTCTCCATATTTCCGTTCCTGTCGACAGTTTTTCGGTGCGTGTATCCACATTAATTTCATTTTGTTTCGCATTTCTGAGGTGTGGCAACGCCAATGTGCACAGCGGCAACTAGCAACACCAACACCAACAACATCGCGACAACAACAATAGAAGGCTGTTCAAACTCCGCGCTTAGTTCATTTGCCTCTTCCTTTTGCATTAGAAAAGCGAAAAATAGCAGCAAGACATGCAGTCAAATTGAATTCGAAATGAAATGCCAAGAAGCAAACATTGCTGCCTGGCTCCAGTTTTTCTTTGCTTGTTTTTCTTTTCTTCTTTTTCCCTAATTTGCAATGCAAATTTTTTTCGGCGCTCGCACTGTGAAAATTGTGCGGCTGCAGCTTTCCTCGTGACTGCCGTTTTTACAGGCAATTTATTGTAGGCGGTGGCGTATACGTGATTTTTTGGCATTTCTTCTTATCGCACATCTCCTGGAAGTTGAATGCACTCTTTGGCCATTGGATTTAACTTTGATCACCAGCCCACTGGAGGATGATTAAGATGGGAGCCTTAAAGCTGTCGGAAAAAAATAATTTAGCCATTAGGTGGCTTAAATCAATTACTGGTGACACTTGTCGATTGATTGCGCTTGTGATCGTGATTGTGATTGTGGCTGTCCCGTGTTGCAAGAAGGTGACATTTTGGACGATGGCGAGTGGGTGACATGGCGGCAGTGACAGCAAACTCATTTAACAAATTGCACTGCGACATGTTGCACACGCGGCGTATGAGCAATGTGCCATTGCATAAGCGACCAGCTGGACAACTTTCCAGCGGAGGAAATGTGTAAACCAATGCAATTTTCCCTTGCAG
Seq C2 exon
AGCAACAGCAGCAGCCACTGCCGACGACACAGCTGCAACAGCAGCAGCAGCACCAGCAGCAGTTGCAACACCCGCAGCAGCAGCAATCTTTTGGCCTAGCAGACAGCAGCAGCAGCAACGGCAGCAGCAACAACAACAACGGTGTCTCCTCGAAATCATTTGTGCCCTGCAAAGTCTGTGGCGACAAGGCATCGGGATACCACTATGGTGTAACCTCCTGCGAGGGTTGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004865:FBtr0078306:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.870 A=NA C2=0.590
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0010513=zf-C4=PU(32.9=29.5)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0077963
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0297287, FBpp0297288
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)