DmeINT0020263 @ dm6
Intron Retention
Gene
FBgn0266084 | Fhos
Description
The gene Formin homology 2 domain containing is referred to in FlyBase by the symbol DmelFhos (CG42610, FBgn0266084). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (8 unique). Gene sequence location is 3L:8753619..8798719. Its molecular function is described by: actin filament binding. It is involved in the biological process described with 12 unique terms, many of which group under: anatomical structure morphogenesis; epithelium development; multicellular organismal process; positive regulation of cellular component movement; programmed cell death involved in cell development. 43 alleles are reported. The phenotypes of these alleles manifest in: intracellular non-membrane-bounded organelle; multicellular structure; intracellular organelle; cytoskeleton; intracellular. The phenotypic classes of alleles include: increased mortality during development; stress response defective; phenotype; fertile.
Coordinates
chr3L:8786300-8787344:+
Coord C1 exon
chr3L:8786300-8786437
Coord A exon
chr3L:8786438-8786621
Coord C2 exon
chr3L:8786622-8787344
Length
184 bp
Sequences
Splice sites
5' ss Seq
TGGGTAAGT
5' ss Score
10.24
3' ss Seq
CCATACCATGCCAAAAATAGGCC
3' ss Score
2.61
Exon sequences
Seq C1 exon
CTCGTGATGGTGCAGGCGTGACACCAGGACTTCGAAGAAGACGTGAGCGGGCGGAGCGGCATAAGAGCTTTCTGAAGGAGCAACAGGAGGCGGCGGCCAATGGAATCTTTGCTGCTCTCGAGCAGCGGGAGGGACTGG
Seq A exon
GTAAGTTCTTGATCTAAGATCCTAATTTGTTTACACAAGCTGCTTTTGACTTGAGCGACTAACTAACTTGTGATTCTCTCTCCCACCGAAACGCTAATCACTGTGTGTATTATTGTCCCGCTGTTCACCCGCTGATCATGCTAACCACAACCAAACAAAAAACACCATACCATGCCAAAAATAG
Seq C2 exon
GCCAGATTGTAACCGCCATACCCGCTACCATTCAAACCGGCGATAGTCCGCCTCAGTCCTTGCAACATGAGGTGCCACCGTGCAACAACATCAGCGGAATCACCAACATTAGTAACAACAATGTCAGCAACCTTAGCTGCAATGACACGCCGAACAACAGCCTCTTGGTGATGAGTCCTAGCAAGCAACTGCTCACTGGAAGCCACAGCATCTCCATTATTAACAACAGCTTCGATAAGGCGAGCAATAACAATCAGAGCGAGTTCCTGACCAAGAAGAACCTATTCCGGGAACGCAATTCAACTGTGATCAATGGTATTATGAAGAATATCCAGCAAACCGATAGTGCCTATAAGAAGTACGAGAACGAAGCGAACCGGCTGAACAACTATTACAGTCAGTCGCCGAAACATCAGATCCATCAGCCCATTCAGCCAACGCCGGAAGTCCTTTTGAGTCCCAAAAAAACGCTAAATGCCTCTGGGTTTGATTTCACGCCCGCTCCCCTCAGTTCCACCCCGGTTAAGTGTGATGTCCCGCCGGAACCGGAGCCACTGAGTCCGGTAAAGAAACCCGCTGCGGCACCACCACCGCCTCCTCCACCGCCACCGCCGCCACCACCACCACCTGGTTGGTGGCACGCCCCCATCTACAACAGCCCGCAAGCTCGAACCCTAACCAGTACTAACCCAGAGCTGCTGCCGCATCCTGTGGATCCTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0266084:FBtr0302085:9
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.768 A=NA C2=0.847
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0291295
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0291296, FBpp0291739, FBpp0291740, FBpp0297585, FBpp0297587, FBpp0306020, FBpp0306021
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GGCCAATGGAATCTTTGCTGC
R:
GATGCTGTGGCTTCCAGTGAG
Band lengths:
256-440
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)