DmeINT0021503 @ dm6
Intron Retention
Gene
FBgn0034012 | Hr51
Description
The gene Hormone receptor 51 is referred to in FlyBase by the symbol DmelHr51 (CG16801, FBgn0034012). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2R:15331325..15339384. Its molecular function is described by 6 unique terms, many of which group under: organic cyclic compound binding; binding; heterocyclic compound binding; zinc ion binding; regulatory region nucleic acid binding. It is involved in the biological process described with 13 unique terms, many of which group under: rhythmic process; metamorphosis; rhythmic behavior; brain development; regulation of neurogenesis. 25 alleles are reported. The phenotypes of these alleles manifest in: neuron projection; plasma membrane bounded cell projection; cholinergic neuron; cellular anatomical entity; thoracic segment. The phenotypic classes of alleles include: circadian rhythm defective; phenotype; increased mortality; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chr2R:15331325-15333967:+
Coord C1 exon
chr2R:15331325-15331646
Coord A exon
chr2R:15331647-15333576
Coord C2 exon
chr2R:15333577-15333967
Length
1930 bp
Sequences
Splice sites
5' ss Seq
AAGGTAAAT
5' ss Score
8.88
3' ss Seq
AATCTGCTTCATAACTTTAGAAC
3' ss Score
6.03
Exon sequences
Seq C1 exon
AATCTGAAATCGTACATCGAGACGTTAACATCATCATCGCGGCACACTCGCAGCGCCGTCGGATCGGATTGGTTCGGTTTCATCAGCGGGAATCAGAGGACCGTCCACTTGCCGTCGCCTCTCCACGATTGCAAATTAATATGGAGCCTACTGCGATGAACCCGAAAAGTGCCATTTAAAAGTGGTGTTTTAGAAATTCTTACAAATAGTGTCAATTGTTAATAAACTTTTCAACGAGGTGTGATCTTTAATCGCAGTCCGCCAAAGCTCAACAAAATGAATAAGGAAGAAAATTCCTCCGAAACACGACCATCTTCTCAAG
Seq A exon
GTAAATTAGTGTGTTAATAAAAACATGAGTATGGTGATGAAATATATTTATTAAGCTGTAAACACAAAGGTGTGGTTTCCTTACTTAAATACATAAAAAAATAAATATACAAGATGGCCCTAATGGTGGCTAAAAATTCCTTTACCAACAAATTTTAAAAAGGACAATATCACGTTTGTTGGGAAATTGTGCGTGAAATATAATTACGTTTCTTACACCCACGATTAATTAGGACGGATAAGATAGGAAAATAAAAAAAGTGATATGTTAAAGAAAAAAACGGAAAGGATGTGAAAGCAAAGATTACAAAAAACGACTGGCATCGTAATATAAATTAAATTTAAGCTTTTTCATTCTAATTACCCGACGGAAAAAATTGTTTCAAATGTGAGTTGTAATTAGTGCCGAAATAATAATGTTATATCGAAAACTAACACACATTTTAAGGATTGAGTTCCTAGCAAAAAAAAAACTTTAACAATTCATTTTATGATATTCAGATATGACTCCTTTTTTAAGCGAATTCTTATACGTCAATTATAAGTTTAGCGATTTGAATAGAAAATCTATTTTATAGCTGTGTGACCAATTTAAATATAATGTTAAGAAGTATAACTTTTTATATGTTGAAATGACTGGATCAATTGTAAAATGCCCAGACTAAAACATGAAAAGAAACAAGCGGATTCTGATCGCTCTGCTCGGAAATCACATTGGCAATTTTAATTACCAATTTGCAGGAACCAGTTGTCTGCGGAGACACTCAAATCAAATCGATGCCCAACTTGCTGATGGCATGCACGAATGGCCAGGCAAATTCAATTTGCGATAATCACCAAATTGAATTAGACTCCGAGTCAGGCCGCCAAAAATGTCAGAAATTCATAACACAGCCATCCCGGCGCCCTTAACACTTTTGTGTGCGCCAAAGTGAATTTCAACGAGCCCATAAAATTAACAAAGATGCCCCGGTGCCCCGGAAAATGCAAGCATATGACGCTAATCCTCCGGCTTTGGACCGCAGTCCTGCCAGTTGGTCCCGGCTGAATGGCCGCCTGACTTTGTCTTTCCATTCCAATGCCAAGCAGGAGCAAAACCCAAACCCAAACGCAAACCAGAACCACGAACCCAAATGGTCGAGCGCACAGCCAAGTGGCGAGTGTTACAAATGTGTCCTCAGCCTCGTCCTTGGAACGTCGAGGGTTAAGTGCATCAAAAAATCAGTAAGGAAACTACAATCAAATTAGGGTGTGATGGCAAAACAATCGTCCCCCGAGGCAAATTTGGCGCACAGATTGCTCGGCACGCTCTGGTCGAGAGCCGTTTGGCTTAATGGCACCCTAATTGAATGTGTAAATATATTTGCGGATTACAGGGCGTCAATGTCGCCACGCAGGGATAAGATCGGCAGGTCCTTTGCATCCGCAATCCGGTACAACTGACAAATTGGGATTTAATTTATATGAACTGCATAAGTGATTTTTTATTGCACCACCCATTACCACCGGGAAAACTGGTCTTAAGTCTGGTCGAAAATTTTAAATGTCTTATGCTGGAACGAGATTAATCATTTAATATGCCGATGAAAAGAATAGCTAAAGGACAATCATTACGCGTTAAGTTTAAAAATGTTAAGCTACAGTGCGGAAATTGTATAGAATTATACATTACATTTCTACATTCTGCTAGTATTAGCTAAACATTATGTATACTATTTTTCCCGTTTTATAAACAATTTTGAATATTTATTAATATTTAAACGCCAACTAAGCTTTAACCACTTGCACAATTCGTTGATTTTAAGATCTATATACGAGCTAATAAACCCAACTGTATGATCTTAATAAAGCCGTAGTAACTTCCCAGATAACAAAAAGATACAATTTCGATTCTCTTAGATACCATTCACTAATCTGCTTCATAACTTTAG
Seq C2 exon
AACTCCACAGTCCGCAGCGGCATTGCTACACTCCGCCGCCGGCGCCGATGCACGGACAGGCGCCTCCACCTACATCAACGGGCGTGGCCCCGCCCACACAGCCACCGCCCCCTCATCCCGCCGCCCCAAACGTGCCCAATGGTCGATTGCTGAGCTGGAATCACAGTGCCGCTGCAGCTGCTGCGGCGGCGGCAGCCCAAGCGGCAGCCAACTCCATGAACCACTCGTCGGCGGCGGAGGGTTCATCGATGACCCGGATTAAGGGTCAGAACCTGGGCCTCATCTGCGTGGTGTGCGGCGACACCAGCTCGGGAAAGCACTACGGAATCCTAGCCTGCAATGGCTGCTCCGGATTCTTCAAACGCAGCGTGCGGCGGAAACTCATTTATCG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0034012:FBtr0114456:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=1.000 A=NA C2=0.573
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0010513=zf-C4=PU(52.1=28.2)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0112948
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCCTCCGAAACACGACCATCT
R:
GGATTCCGTAGTGCTTTCCCG
Band lengths:
358-2288
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)