DmeINT0021948 @ dm6
Intron Retention
Gene
FBgn0010051 | Itp-r83A
Description
The gene Inositol 1,4,5,-trisphosphate receptor is referred to in FlyBase by the symbol DmelItpr (CG1063, FBgn0010051). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (2 unique). Gene sequence location is 3R:5517117..5539411. Its molecular function is described by: calcium ion binding; phosphatidylinositol binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol 1,4,5 trisphosphate binding. It is involved in the biological process described with 22 unique terms, many of which group under: behavior; response to nutrient levels; response to starvation; sensory perception; regulation of feeding behavior. 52 alleles are reported. The phenotypes of these alleles manifest in: plasma membrane bounded cell projection; alimentary canal; cellular anatomical entity; developing material anatomical entity; organelle. The phenotypic classes of alleles include: phenotype; increased mortality; size defective; body size defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages.
Coordinates
chr3R:5532857-5536652:+
Coord C1 exon
chr3R:5532857-5533348
Coord A exon
chr3R:5533349-5533886
Coord C2 exon
chr3R:5533887-5536652
Length
538 bp
Sequences
Splice sites
5' ss Seq
GGCGTAAGT
5' ss Score
9.39
3' ss Seq
TACATTTACTTGCCTTTCAGATT
3' ss Score
9.42
Exon sequences
Seq C1 exon
GTGCAACTTCTGGTGTCGGACAGTGACGTGGAGTCCTATAAGCAAATCAAGTCCGATCTGGACATCCTTCGCCAGAGCGTGGAAAAGTCAGAGCTGTGGGTGTACAAGGCAAAGGCCACCGATGAACTGGGGGCCACCGACGCCGGCGGAGATGCTGTTAGCCTGGAGTATAATGCCGCCCTGTCTCAGGAGCAGCGAAACGAGTACCGCAAGGTCAAGGAGATTCTGATCCGCATGAACAAATTTTGCGTAACTGCATCCGGTCCGGGTTCGGTGGTCAAGCCACGCAAGCATGAGCAACGACTGCTCCGCAATGTTGGCGTCCACACTGTCGTCCTCGATCTCCTCCAGAATCCGTACGACGAGAAGGACGACGAGCTGATGAAGGAGCTCATGTGCCTGGCCCACGAGTTCCTGCAGAACTTCTGCCTGGGCAATCAACAGAACCAGGTCCTGCTGCACAACCATCTCGATCTGTTCCTGAATCCGGGC
Seq A exon
GTAAGTTTCTTTTTTGCTTTTCCCAGTTAAATGTATAGAACTCGTCCAAATTCCTAAGAAAGAACCTTGGGGGATCAATTACTTGGCGCAGTTAAGGGAACACCGCTACCGGTTTCAAAATATATATGCATTTTGTATAGTTTTAGTTTACTAATCTATATTCGATCTGTGTATTTCTTACGTACTTTTCTTTAAAAGAAGAAACTAGTTATGTCTTGTTACTTTTTCGATTTCATACATATAGATTTGAAATTATTCTAAAAAGTTCTTTTAATTCACTTTAGACTGGAAACAGATCTACATCAAAAACAAAAAAAGTGCACTGGAGAAAGGTTAATCTTTATATTAATATTTAAATAACATATATGCCTCTGCTTATAAATTTCATATCTGTTATATATCCATTTCACATTGAATCTTTTACACTTAATAGGATGCCCTTATTAATTGAAAAAAAGAATTGCCAGTGCCTTAAATTCTCGGTTTTTCTCATATTGTTGTCCACGAAATGGGATTTTTACATTTACTTGCCTTTCAG
Seq C2 exon
ATTCTGGAGGCGAAGACTGTGTGCGCCATCTTCAAGGACAACTTGGCCCTGTGCAACGAGGTGACGGACAAGGTGGTGCAGCACTTCGTGCACTGCATCGAGATTCATGGTCGTCACGTAGCCTACCTGCAGTTCCTGCAGACCGTAGTGCGGGCGGAGAACCAGTTCATCCGCCGCTGCCAGGACATGGTGATGCAGGAGCTCATCAACTCCGGCGAGGATGTGCTGGTCTTCTACAACGACAAGGGTTCTTTTAACCACTTCGTTCAGATGATGCAGCAGCAGATGCTGCGCATGGAAAAGCTCAGCGACGACAGCCCCTTGAAGTATCACGTCGAGCTTGTGAAGCTCCTGGCTTGTTGCACCATGGGCAAGAACGTCTACACGGAGATTAAGTGCAACAACCTTCTCTCTCTGGACGACATAGTGACCATCATCTGCCACCCGCTGTGCATGCCGGAGGTTAAGGAAGCCTACGTGGACTTTCTCAACCACTGCTACATCGATACGGAGGTCGAGATGAAGGAGATCTACGCCTCCGGGCACATGTGGAGCCTGTTCGAGAAGAGTTTCTTGGTGGACATTAACCAGCTCATCACGAACCCCGCCGCCGCAAGCAACAAGACGCTCCAGGCGTACGTCCTGAATGGGGTAACCAATCTTTTGGGCAGCTTCTTTGCCAGTCCGTTTTCGGATCAGAGTGCCATCGTGCAGTCCCGCCAGTTGATCTTCGTGCAGCTGCTACAGGCTGCGCACAGAATCACCCAGTGCCGCTGGCTGTCGTTGGGTGATCGTTTCAACGTGGAAAACTGCATCCGCACGCTCACGGAGTCGGCCAAAATGCGTAGCATCGCTCTGCCCCCCGAGCTGGAGCAGCAGGTGGCCACAATGTCCAGCAAAACGGCTATGCTGACCCGACAAACCACTAAATGGCTGCTGGCCTCCAAGCAGCCCAAGTATGAGGCTCAGCAGGCGGCCAGTCTGATGCGCTGGGACCGCTCAATCATCGAGGGCTTGCAGGACATAGTGTCTCTCTTGGAGGATCAACTAAAGCCGGTGGTGGAGGCGGAACTATCGCTGCTAGTGGATATACTGTACCGCTCAGAGCTGCTCTTTCCCGCCGGAACAGAGGCTCGGAAGCGCTGCGAAAGCGGTGGATTCATCCGAAAGCTAATCAAGCACACCGAAAAGCTGCTGGAGGAGAAGGAGGAGCGCATGTGTGTAAAGGTTCTTCGCACGCTGCGTGAAATGATGGCCATTGATGTGAACTACGGCGAGAAGGGCGATGCACTGCGACAGACACTTTTGCTACGCTACTTCCAGACCAAAAGCACGCCCAGGTTGCCGGAGGATGAGGTACCTCTGCTCGCCGCTCCTTTGATGGATCCTGCTAAGCAAAACCACCTAGTGACCCACGGACCAGGGGCCAAGTACTTGCAGCGAGCGGGTAAAACGCTTCACGAGATGCAGAACCACTTGGACAGAGAAGGCGCCTCAGATCTTGTGGTTGAGCTGGTTATAAAGTCCGTACATTCGCCCAATATTTTTGTCGAAGCTGTGGAATTGGGCATTGCACTTCTGGAAGGCGGCAACCCTATTATTCAGAAGGGTATGTTCCAGAAGTTCCTTAGTGACGACCTCAACCAGGCCTTCTTTAAAGTCTTTTTTGAGAAGATGAAGGATGCACAGCAAGAGATCAAGTCAACCGTCACTGTGAACACCACCGACATTGCGGCTAAAGCTCACGAGCACAAACAGGACACCAATCTGGAGCTAGACAAGATCGCTCGCAAGCATGGCCTCAAGAGCAACGGAGTGGTGATTACTGAGGAACTAAAGCGGGAACTGCACAATGCCGGACTGGCAACGGCCCGTGCCTATGGGAATGCCCGAAACATCCACTCCGGCGAGGAAAGCTCCGCCATCAGTGTGAACAGTCCGCTGGAGGATATACTGGCCGAGAAGCTGGAAAAGCACAAGGACAGTCGGGATCAGCGCAACCAATTGTCAAACAAGGTGCTGGTCATGCAACCTATCTTGCGGTTCCTTCAGCTACTTTGCGAAAACCACAACCCGGACATGCAGAACCTGCTGAGGAACCAAAACAACAAGACGAACAACAACCTGGTATCGGAGACGCTTATGTTCCTGGACTGCATTTGTGGCTCGACGACCGGCGGCTTGGGATTACTAGGCCTGTACATAAACGAGCATAATGTGGCCCTGATCAACCAGACGTTGGAGGCCCTCACGGAATACTGCCAAGGACCGTGCCACGAGAACCAGAACTGCATAGCCACTCACGAATCAAATGGGCTGGACATAATCACGGCTCTTATTCTGAACAATATCAATCCGCTGGGCGAGAACCGCATGGATCTGGTCTTGGAGCTGAAGAACAATGCCTCCAAGCTGCTCTTGGCCATTATGGAGAGTCGGGGGGATAGCGAAAACGCGGAACGCATTCTGTACAACATGAACCCCAAGCAACTCGTAGAGGTGGCCTGCAAGGCATACCACCAGGAGGAGCTGATCGACGAGCAGGACGATGGGGATGAGCCGGACGCCGGGTCGGATGATGATGACGCCACTGTGAGTCCGCGGGAGGTGGGTCACAACATATACATTCTGTGCCACCAGCTGGCGCAGCACAACAAGGAGTTGGCCGGCCTGCTCAAAGCCTCCGAGGATCCACAGTCAGCCAGCTTCGACGCCAAGACAAGTCAGGCCTTGATGTACTATGCCACGCACACTGCCCAAATAGAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0010051:FBtr0078686:12
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.007 A=NA C2=0.092
Domain overlap (PFAM):
C1:
PF0136516=RYDR_ITPR=PU(51.1=56.7)
A:
NA
C2:
PF0136516=RYDR_ITPR=PD(47.8=9.4),PF084546=RIH_assoc=WD(100=13.1)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0078335
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0078336, FBpp0310670
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTTTGCGTAACTGCATCCGGT
R:
GAATCTCGATGCAGTGCACGA
Band lengths:
355-893
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)