DmeINT0026336 @ dm6
Intron Retention
Gene
FBgn0026056 | Rlip
Description
The gene Ral interacting protein is referred to in FlyBase by the symbol DmelRlip (CG11622, FBgn0026056). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3R:21017684..21020753. Its molecular function is described by: Ral GTPase binding; GTPase activator activity; protein binding. It is involved in the biological process described with: small GTPase mediated signal transduction; regulation of Ras protein signal transduction; positive regulation of GTPase activity; receptor-mediated endocytosis. 10 alleles are reported. The phenotype of these alleles manifest in: trichogen cell. The phenotypic classes of alleles include: fertile; viable; visible. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr3R:21018130-21020753:+
Coord C1 exon
chr3R:21018130-21019014
Coord A exon
chr3R:21019015-21019444
Coord C2 exon
chr3R:21019445-21020753
Length
430 bp
Sequences
Splice sites
5' ss Seq
AAAGTGAGC
5' ss Score
5.89
3' ss Seq
ACTAAATTGTCATCTCTTAGGTA
3' ss Score
7.33
Exon sequences
Seq C1 exon
AAGTCCATCCAAGTCGAAAAAGTCAAAGACCTTTAAGTTCACCAGCTCCAAGAGCAAGGAGAAGCGGGAAAAGTCGCGGGACAAGTCTGAAAAAGACTCGAAGCACGCAGAGGAGGAGCCTTCCGTCTCCCACAAGGTCAAGGAGAAAGAGCGGGATAAGGAGAAGGACCGTGATGAGCCCAAGAAGAAGGACAAGGAGGAGAAGCGCAAGGAAAAGGACAAGAAGGCTGACAAGAAGGACAAAAAGGATAAGAAGAGCAAGCAGCTGTCGCAGCAGCAGGACGACGTCTCCGCCGCGGAGGAAGTGCTGGCACTTGGGTATCCCGTCTTTGGGGTGTCCGTTAGCTTGGCGACCGAACGATCCCGCTGCCACGACGGCGTGGACATTCCCCTGGTTGTGCGCGACTGCATCGACTTCCTGCAGGATCACCTGAAGTGTGAGCAGATCTACAAGATTGAGCCCATCAAGACGCGTCTGATGCACTTCAAGCGGTTGTACAACAACCGGGAGCACGACTCCGCCGTTGATGAGCTCAACCTGCCTACCGCCTGCAGTCTGCTGAAGCTCTTCCTGCGCGAACTGCCGGAGCCACTGCTGACCACCGATCTGGTGGCCCGCTTTGAGGAGGTAGCCTCTCATCCGAAGGTAACCACGCAGCAGGCAGAGCTGCAGCAGCTGCTTGAACAATTGCCCAAGTGCAATCGCACCCTCTTGGCGTGGGTGCTGCTCCACTTCGACGCGGTGATCCAGCAGGAAAGACACAATAAGCTCAACGCTCAGTCGCTGGCTATGCTGCTCAGTCCGACGCTCCAGATGTCTCACCGACTAATGGTGGCCCTACTCTGCCACTGCAACAACTTGTTCGCGGACGTCCAGCTGATAAA
Seq A exon
GTGAGCAAACACCGGCTAGCCGGATAACAGTGGTGGGAAATATCCAAGTACCTTTGTGTTGGTAAAAGAGAAGTCCACATTTAACAACTATAGTTAAATCACAAGAACGAATCGAAGTCATAGCTCTGAAGTTAACTACTAAACTGTTAGTTTTAGTAAACTGTTAGTTTCCATATTTATCTAATGATATAAATTGTTTTTTTATATGTATAATAGGTACTTATAAGAACCCAGATAATTCCCACCACTGTTGGCAGTTGATAAGATTGCTGCTATAAAAATCGCCAGATTTAGTCGTTTATTTTGCAACCGACGATGAGCACATTACCCCGTAAACAGAAGCGCTTTCCACGTTTCGCCAGTTTTCTAATCAGGCAGAATGGCACACATTTAAACAAAGTTATCATAATACTAAATTGTCATCTCTTAG
Seq C2 exon
GTATGTGCCCCCTTTAACATCGACCAGCCCAAAGCTTCCGGATACGCCGGAGGACATCCAGACGGAGTTGCGCAAGCAGGACAGCCTCCTGTCCCAGATCCACAGCGAGATGAACGCCGGGTTCATTACCAAGAAACGCGAGGAACAGCTGTGGGAAGTGCAGCGCATCATTACCCAGCTGAAGCGGAAACTACGAACTTTTGAGAAGAAACAGGAAAAGACTGCGGAGGAAGTAGACAACAGCAGCAGTGCTCCGCCCGCTGTAGCCAGTGAAGATACCACTGACTCCAAACCAGCTGGAACTCCAGCCGTATCTACGAACAACAGTATTTCCCAGGAAGAGCCAAAAACCGATACACTAACTCCGAAAGATGCTCCTAACGATTTTACTATTGATCCCAGCACTGGCTTTATTTTGCTCCCCAAATCAAATCCGCACCGCGAAAATTTGCTGCGGCTCCAAATTGAATATGACGAGCTAATGGAATGGCAGAACGAACTAAAAGCACGTATCGTCGCCGAGCGCAACGAAGTCTATAGGCTCAAGCAGCTGTACGAGCAGCAGTCAATAAACAGTCAAATGGCCTCCTTGGCCTCGGGATCTCAGGCTCCCCCAGAATCCGACTATGAGCGGATAATCGAGCACTATACACGGGAGAATGCGCTGCTGGAGCACAAGAAGAATATGCTGGGCATGGAACTAAAGGAGGAACGACGGGCCTGTATTGCTCTACAAGTTGAGCTGCGGCTCCAGCAGTTTTAATGTATTAATTCGATTAATGTATTACTTGGATGGGTCAATTTGAGGGATATAACTAAGTTCCTATTCCGGAAACTTAATGGTCACATTTCCAAAGAAACATAAAAGGTCTACTAGGCAATCATAGGAGGTTTCTTAGATTCGTAGAAGACAATTCTATGTCACATATCTAAAATATTCAAATGAATAAACTTGTAAAGTTTTTGATAATTCATTTATCTGCAAACGTAGTCACTGTTCTAAACAGTGTCCTTTGTGAATTGCAATATATGAGAATTTTCAGTTCAGCTTTTAAGGAGATAAAATACTGCTAAAACATAAAACGGATTCCTCATGCCTAAAGTCAGTTTATTGTTTATTTGGAAATGAGCTAGTTTCAGACTTGACCCACCGAAATATATGTATGTATATAGGGTTACCAATTTTAAATCTCAATGTCTACTTGCGATCAAATGCTTTGTTCAAACTATAATTACTGTTAAACGGCGCAAAGCCCCAAAGAAATCTTGTTAGACAACTTTACTGCTTTCAACAATTAAATGAGAAAAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0026056:FBtr0084002:3
Average complexity
IR
Mappability confidence:
NA
Protein Impact
Alternative protein isoforms
No structure available
Features
Disorder rate (Iupred):
C1=0.330 A=NA C2=0.465
Domain overlap (PFAM):
C1:
PF0062022=RhoGAP=WD(100=49.7)
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0083406
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0307748
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CCACTGCAACAACTTGTTCGC
R:
GGAGTTCCAGCTGGTTTGGAG
Band lengths:
345-775
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)