Special

DmeINT0031448 @ dm6

Intron Retention

Gene
Description
The gene deformed wings is referred to in FlyBase by the symbol Dmeldwg (CG2711, FBgn0000520). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is X:2727698..2730042. Its molecular function is described by: DNA binding; chromatin insulator sequence binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; zinc ion binding; protein binding. It is involved in the biological process described with: regulation of transcription, DNA-templated. 59 alleles are reported. The phenotypes of these alleles manifest in: pigment cell; anterior vertical bristle; compound sense organ; somatic cell; cell. The phenotypic classes of alleles include: increased mortality during development; phenotype; increased mortality; partially lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.
Coordinates
chrX:2727698-2728934:+
Coord C1 exon
chrX:2727698-2728263
Coord A exon
chrX:2728264-2728544
Coord C2 exon
chrX:2728545-2728934
Length
281 bp
Sequences
Splice sites
5' ss Seq
AATGTAAGT
5' ss Score
8.62
3' ss Seq
AACACCTTCTTCATCCGCAGTTG
3' ss Score
9.51
Exon sequences
Seq C1 exon
ATAATATCGCATAAGCATCTGCTCTAAAAACGCATAAAAATTGAATTGCAAGAAGTAGAAGAGCGAAACGTCATAAAAGCGGCAAATCCGGCGCTGTCCGACAAGAACCACAGGGGAAAGCGGATAAGGACATCATGATGAATAGCAAGATCGCCGAGGTAGTGGTGCTCAACTGCCGGACGTGCACGCGTGCCTGCAAGCTGCACAAGCCGCTGCAGGAGGAGATCGATCTGGGTTCGGAGGGCAGCACCACGCTGGCCAGCATGCTAAACTACTGCACGGGACTCTCGTTCGAGCCGCAAGACGGCGCCGCCATGCCGCAGCACATCTGCCTCCACTGCCTGCAGCTGCTGGAACAGGCGTTCAACTTCAAGCGCATGGTCATCGATTCGGACGAGCTGCTCCGCCTGGGCCTGGACGAGGCGCGCTGCTCCAGCTTTCACGAGAGTCAGACTCATAGCCCCAACCAGAGCCAGCAGCACGACCAGCAACAGCAGGCGTTCGACTCCACCGAGGAGTACGTCATGATCGAGATGCTCAACGAGGAGCAGGAGAACGTCGCCAAT
Seq A exon
GTAAGTATCTATCACTTCACGGTGCAATGGAATGCAATGGTTCTTGTCCACTCCCATAGAGGATTAACGATTGCTCACAGCGGGCACCAGTCACTCAAATCGATTCACTTATATTGTGGCTCTTTGGGATGTAGTAGGGTAGGTCGGTGCCAAAGGAGTGCAACCTGTACCTCCATACAATGGATAACTTGTCTGCTCTTGGTGACACTACGTCTAAATAGGAGATGGGCTTCATCAAGTCTAACTCCAAAGTAAAACCATAACACCTTCTTCATCCGCAG
Seq C2 exon
TTGGATGAAGAACTAGCAGAGGAGGATCGTCGCATCTTCGCGATGACCGTGGATGAGGAGGAGGAGTTTCTCACCGAGGAGGTGGATCAGGATGACGAGCTGTCGGAGGAGGAGCACCAGCTGGCACAGTCGGGCGACCAGCAGGAGGAACACATCACTATGGAGAGCGTGCATGAGTTTCAGCCCGCCGAAGTGGAGTATGTGACCATTAAGAATGAGTTCGAAACGATCGTCACGGAGGAGGATGAGTTCGAGGTGATGAACGACTCCGGCGCCCACGACGCCATACTGGACTGTCAGATGATTGTGATACCCGCCGAGGGAGCCATTGACGAGGTCATCGGCGAGGAGACCCTCGAATTGGAGGGGGATGGGCGCGAGGAGCATCTG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000520:FBtr0070487:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact

ORF disruption upon sequence inclusion (1st CDS intron)

No structure available
Features
Disorder rate (Iupred):
  C1=0.306 A=NA C2=0.715
Domain overlap (PFAM):

C1:
PF0777610=zf-AD=WD(100=55.6)
A:
NA
C2:
NO


Main Inclusion Isoform:
NA


Main Skipping Isoform:
FBpp0070465


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGTTCAACTTCAAGCGCATGG
R:
TCGTCATCCTGATCCACCTCC
Band lengths:
304-585
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)