Special

DmeINT0033781 @ dm6

Intron Retention

Gene
Description
The gene masquerade is referred to in FlyBase by the symbol Dmelmas (CG15002, FBgn0011653). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3L:4161666..4167464. Its molecular function is unknown. It is involved in the biological process described with 7 unique terms, many of which group under: multicellular organism development; system development; organic substance metabolic process; regulation of cell projection organization; muscle attachment. 13 alleles are reported. The phenotypes of these alleles manifest in: longitudinal connective; midline crossing tract; peripheral nervous system; ventral nerve cord; commissure. The phenotypic classes of alleles include: increased mortality during development; increased mortality; phenotype; sensory perception defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed within 12-18 embryonic stages, during early larval stages, during late pupal stages.
Coordinates
chr3L:4165243-4165637:-
Coord C1 exon
chr3L:4165465-4165637
Coord A exon
chr3L:4165393-4165464
Coord C2 exon
chr3L:4165243-4165392
Length
72 bp
Sequences
Splice sites
5' ss Seq
CAGGTAAGA
5' ss Score
10.77
3' ss Seq
TAATTTGTCTTTCTTTTTAGGTC
3' ss Score
12.44
Exon sequences
Seq C1 exon
ATTCTTGGTAAGAAATGAACACGTGCTGACCATTTTGGACCAACGAATTATGCCAAGACATTCGAGCACAATGAGCCGCCTTGTTCTGCCCCTGATCTTCAGCATTTTGCTGGTCAGTAAGCCATCGCCATCACAGGCTCAGGATGAATCCCTGGCTGGCAGTTTCCTATCAG
Seq A exon
GTAAGAATTAACTTCGTGCTTCTTAAGAATTCTGGAGACCAAAGAATATATATAATTTGTCTTTCTTTTTAG
Seq C2 exon
GTCTTTTGGACACCATAACGAGCACCGCAGACTCCAAGGATTGCCCTGGAGTATGTGTCCACACTTTGGCAACTTTAATTTGCTACGAAGTTCTAGACGATGTGGCTTGTCCTTCGCCCAGCATGAAATGCTGCATAGAAAATGCTCCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0011653:FBtr0073260:2
Average complexity
IR
Mappability confidence:
NA
Protein Impact

ORF disruption upon sequence inclusion (1st CDS intron)

No structure available
Features
Disorder rate (Iupred):
  C1=0.095 A=NA C2=0.020
Domain overlap (PFAM):

C1:
NO
A:
NA
C2:
NO


Main Inclusion Isoform:
NA


Main Skipping Isoform:
FBpp0073116


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
FBpp0304905
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGCCAAGACATTCGAGCACAA
R:
CAGGGCAATCCTTGGAGTCTG
Band lengths:
171-243
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)