DmeINT0034040 @ dm6
Intron Retention
Gene
FBgn0259749 | mmy
Description
The gene mummy is referred to in FlyBase by the symbol Dmelmmy (CG9535, FBgn0259749). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (2 unique). Gene sequence location is 2L:6468538..6473904. Its molecular function is described by: UDP-N-acetylglucosamine diphosphorylase activity. It is involved in the biological process described with 13 unique terms, many of which group under: regulation of biological quality; chitin metabolic process; embryonic epithelial tube formation; regulation of locomotion; nucleotide-sugar metabolic process. 46 alleles are reported. The phenotypes of these alleles manifest in: early extended germ band embryo; primary segmental branch primordium; cellular anatomical entity; cell-cell junction; distal axon. The phenotypic classes of alleles include: lethal; viable; neuroanatomy defective; some die during embryonic stage; lethal - all die before end of embryonic stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during early pupal stages.
Coordinates
chr2L:6471328-6473904:-
Coord C1 exon
chr2L:6473631-6473904
Coord A exon
chr2L:6471715-6473630
Coord C2 exon
chr2L:6471328-6471714
Length
1916 bp
Sequences
Splice sites
5' ss Seq
ATGGTTAGT
5' ss Score
7.07
3' ss Seq
TTGTCTCTGGATTCTTGCAGCTG
3' ss Score
8.22
Exon sequences
Seq C1 exon
CGATTCTCCGCCCAGTTCTTGGGAGACTGTTTCATTCGGATTGTGCATTTTCCGTTTGCCCATGTAATCAACAGCCGCACGCAGTGTGAATTAAACCTCGTCAGGACTAGCACGATGCCATAGAATCCTCGACGGACGAGGCACAGTCACTGCATAAACAATTCGCACGGAGTGAAGTGGAGCCAAAAGTAATACAGGGTGTTCCCAGACAAAATGGGTCGCAGCAACTTCAGTTCGCATCACCAGCAGACTCATGTGAGGCGCCACCGCAATG
Seq A exon
GTTAGTTGGTAAAAACCCACTCGAAAAAGCAAACTGATAATGGTAGCGCAATAGTTGGAGCCCAGAGCTGCGATAAGAAAAAAGCGGAAAGCCCACAATCACACACACACACACAGCAGTGGGTGTATGTAAACAACTTACTTGCTATCGCTGTTTTGTTCCGTTTTTGGGTACTTGTGTGTGTGTGTGTGTGTGCGGGGAGTGTTTTTGTTGCTGCAGCTTTATCTTTTTTTTTATGCGCACTCATACATGCAGACAAGTGTTTTGCTTCGTGGCAAAAACAACAATAATGGTCAGTGTAGCGAATGTAAAATACCCTCTTATCACTCCTTAAATGTATTTTTTACCCCGTTTTCCTTAAATCGATATAGATATATATTGATTTGTTATACATTTATACATTTTTATTTATATGACATCTTATCTTATCTTATAAAGATGCATATAATGGTGATATTTTTCAATTACTGTTATTCTTGTTGATACCTTATTATTGCGCTTACTTTTCCATTCCATAATATTTAATATAAACCATTGCGCTTAAGTTAATGGGTATTAAAACCGAATAAACCGGCTGAGCACCGACTTAGTTTTGCCATGTTTTTGTCAGTTCTTGGCTCGCCTTAATGCCATAACCTTTCCAACAAATCCCGATAACCCACTCAACTAGTTTGTAACCCGTTTATCAGGAACTGAACTGTATGAACTATATATAAATATGTGTCGCCCTTAGGAGTTTCCTTGTGGCTGGCGTTTCTTGGACTGTGGCACCTCTTACTTTCACTAAAACTAAAGCCCGTGTTCAGGGCCATTTGGTTTCGAATTCGATTTCGGTTTCTGATATTTCGCTTTGCATTTGCAACACGCTGCTGCTTGGCGAATTGGCCAAGCAGCGAAAATCCGATTGAAATTGCTGCAGTCCCAGTAGCCGTATCAGCCGTGTAATCAAGAGAGCCGACCGCAGACACGACTAATTGATACCCTCACTCACAAGTTACATGTTCTTAAGTCTTAAGTCGTTGGGAATTCCCGCATTCCTCTTATTCAATTTTAATAAAAACAAGGTTGAGCTCATTAAGATCACTTAACAGATGTACATACATACAAATATTTATATCTACATATGTAGAAATACGAAGCAAAGCTGTTAAATTATAATTATAACTTTTACGTTTCACCTATAAGGAATATGTTTCTCTTTCGCTTTCTGAAACAGATTATAATTAAACAATGTAGTATCTAATACCAAAAAGAGACTGTGATTGATTGGGCACATTTTCCGCCATGATCGCGATCCCGCCCTTCAGGTTTTTACAGGGTATGGCCAAAACAACTGGCGTGGCCATGTTAAAACGCGGCTGCAAATACGTTAAGAGACACACGTTCGCACACATTCGCGCCCAAATACCAGATACCAATATAACCTGCACACGAGCTACTGCCATTCAGATATTCAGGCGTTCCCACAGAGACACAACCAGATGGAGGCGAAGGCGATGGTGGTTGTCTGACGGCTCCACTTTGAGCAAGAAAAACCACTGAGGGCGATCGCTTGGCGCTCAGTTGCGCTTTGGTTACCACGTATAGCGGAACGCAACAAAGCCCGGACAACCCGACCACTGTCTTTTTACCGCATTCGCCAAATAATCAGTCAGCCAGCGGAGAGAAACGTAAATACACACCTTCGGGAGAGCCCGTTCCATTAGCTGAATTAACAAACAGATAGCAGCAATTAATATATGATTCCAATGTGATCTCTAAAGATAAAACCTTGTTTTTAACTGTGTGTTCGCATTTAAAATGTTCCAAAATTATGGTGAAGAATATAACGTATTAAGTAGGATACCGCGTAATAATATTTTGTCTCTATTGTTTATAATTTGTTAGTCAAATATCTTGTCTCTGGATTCTTGCAG
Seq C2 exon
CTGGCGGTGCCACATCAAAATCACCAAACGCAGCCAAAACTTCGCCAACAATGACGGACTACCTGTCGCTGCACTCGCGACTCGCCCAGGTGGGCCAGGAGCACCTGCTCAAGTTCTGGCCGGAACTAACGAATGACGAACGCATCGACCTGGTGCGGGACATCGAGGAGCTGAATCTGGACGAGATCAAGCTGTATTTCGACCGCGCCACGGTCTCAATGAACGAGAATGGCATCAAGCTGGACGATCGCCTGCAGCCGCTGCCCGAGGGCAAGCTAATCTCCATTGCCAGGGCGCCGCTGGAGAAATTGGACGCCTACCGAGACGAGGGTCTCCTCCAGATCAGCAACGGACATGTCGCTGTGCTGCTTATGGCAGGCGGACAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0259749:FBtr0079268:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=1.000 A=NA C2=0.065
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0170413=UDPGP=PU(17.6=52.3)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0078898
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0078899, FBpp0308834
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGGAGTGAAGTGGAGCCAAAA
R:
TCGTCCAGCTTGATGCCATTC
Band lengths:
354-2270
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)