DmeINT0037185 @ dm6
Intron Retention
Gene
FBgn0003567 | su(Hw)
Description
The gene suppressor of Hairy wing is referred to in FlyBase by the symbol Dmelsu(Hw) (CG8573, FBgn0003567). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (1 unique). Gene sequence location is 3R:14304455..14308589. Its molecular function is described by: sequence-specific DNA binding; protein binding; chromatin insulator sequence binding; euchromatin binding; DNA binding. It is involved in the biological process described with: negative regulation of transcription, DNA-templated; protein localization to euchromatin; negative regulation of chromatin silencing; response to ecdysone. 87 alleles are reported. The phenotypes of these alleles manifest in: cuticle; trichogen cell; egg chamber. The phenotypic classes of alleles include: increased mortality during development; increased cell death; phenotype; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
Coordinates
chr3R:14307098-14308589:-
Coord C1 exon
chr3R:14308524-14308589
Coord A exon
chr3R:14307971-14308523
Coord C2 exon
chr3R:14307098-14307970
Length
553 bp
Sequences
Splice sites
5' ss Seq
TAGGTAAAT
5' ss Score
6.62
3' ss Seq
CCAATCGATCTTAATTGCAGGCT
3' ss Score
6.17
Exon sequences
Seq C1 exon
GCAACGGTCACACTGAATTTTCATACACAAACGCTTGTCGTGTTGGAATTTAAAGCATAAAATTAG
Seq A exon
GTAAATTGTGATTTATTATCGGAAATGCGGTCAAAACCCTTTAAGGAACGCATCCCGTGATATGAGGACATGTTTGTGAAGCAAATACCTTAGCCAGTGACTTGATAATTTCACGCTCTTTATCGGCGATGGCAGTCACTTTCTTTCGCTGCGGAGCAGAAAAGTGCACTTCTAATCAGCAAAATAAGTGGTTAAAACCGATCCTCCACGTCCTTCGCCGGCACAAAATCACATTAAATATTTGAAAAGTATGCTACGGATTTGCGAGTGTATTAGAATTATTTGCTACCCCTTTGAAATACAATTTTATTTCAGAAGAAAACTTGTTGCGTTTTCTGTGCGTCAGGCGCAGGTAGTGTTGTCTCGCTCACACCAAGGCCGATCGATCGTAAAGATCGAACAGCGCGACGCCATTTTTTCTTAGCAGCTTTTGGGCGTGTGTTGGTGACGCTGGCAAAATGTGATGTTCAGTAAATCACGTGCCTAAAAGTAGACTAAAGCGGTCACTGGTTATCCTGATCCTGAATTATCATCCAATCGATCTTAATTGCAG
Seq C2 exon
GCTGGTATCACCAACATGAGTGCCTCCAAGGAGGGCAAGGAAAAGAAGGGCAAGCTGCTGGGTGTGGAAAACATTTCGCCGCCTAAGGACAAACGTCCCGCCACCAGGATGAAGCTCTTGAATGACGTGGGAGCTGGTGAGGATTCGGAGGCAAGCACTACTACTACCACATCAAGAACTCCCTCCAACAAGCAGGAGAAGCGTGGCAGTGTCGCTGGATCGCGCATCAAAATACTCAATGAAGAAATACTGGGCACTCCGAAAACTGAGAAACGGGGCGCCACAAAGAGCACAGCTCCGGCTGCTTCCACTGTGAAGATTCTGAACGAGAAAAAGACACCCAGTGCTACCGTGACAGCCGTGGAAACTACCAAGATCAAGACGTCTCCCAGTAAAAGAAAGAAAATGGAGCACTATGTACTTCAGGCTGTGAAATCAGAAAATACCAAGGCGGACACCACGGTTACCGTGGTCACCGAAGAAGATGACACCATTGATTTCATTCTAGCGGATGATGAGGAAGTAGTTCCGGGCAGAATAGAAAATAACAACGGCCAGGAGATCGTTGTCACCGAGGACGATGAGGATCTAGGGGAGGATGGTGATGAGGACGGTGAAGACTCCTCAGGCAAGGGCAACTCTAGCCAGACAAAGATCAAGGAGATCGTGGAGCATGTGTGTGGCAAATGCTACAAGACCTTCCGTCGCGTTCAGAGTCTGAAAAAGCATCTAGAGTTCTGTCGCTATGACAGTGGGTATCATTTGCGCAAAGCCGACATGCTTAAGAACCTGGAGAAGATCGAGAAGGATGCCGTGGTGATGGAGAAGAAGGACATATGCTTCTGCTGCAGCGAAAGTTACGACACCTTCCAT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0003567:FBtr0082946:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
5' UTR
No structure available
Features
Disorder rate (Iupred):
C1=NA A=NA C2=0.671
Domain overlap (PFAM):
C1:
NA
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0082404, FBpp0082405, FBpp0301708
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCAACGGTCACACTGAATTTTCA
R:
CCCCGTTTCTCAGTTTTCGGA
Band lengths:
344-897
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)