DmeINT0038481 @ dm6
Intron Retention
Gene
FBgn0265434 | zip
Description
The gene zipper is referred to in FlyBase by the symbol Dmelzip (CG15792, FBgn0265434). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (7 unique). Gene sequence location is 2R:24990570..25011965. Its molecular function is described by: actin filament binding; protein binding; ATP binding; motor activity; myosin light chain binding. It is involved in the biological process described with 28 unique terms, many of which group under: open tracheal system development; midgut development; gland development; wound healing; cellular response to external stimulus. 63 alleles are reported. The phenotypes of these alleles manifest in: photoreceptor; somatic precursor cell; filamentous actin; actin-based cell projection; denticle. The phenotypic classes of alleles include: some die during larval stage; wound healing defective; increased mortality; phenotype.
Coordinates
chr2R:25010380-25011463:-
Coord C1 exon
chr2R:25011312-25011463
Coord A exon
chr2R:25010617-25011311
Coord C2 exon
chr2R:25010380-25010616
Length
695 bp
Sequences
Splice sites
5' ss Seq
TCGGTAAAA
5' ss Score
5.48
3' ss Seq
CGATTTGTTTTGTCCGACAGAAA
3' ss Score
8.38
Exon sequences
Seq C1 exon
GGTCGGCAAAACGGCAAGCGGCGAAAAACAGTGAAAAAAAAAGGGGGAAAGCGAAAAGACGTGCTCAGGAACTGCGGTCGAAGTCTTTGTGAGTGTGTGTGGGTGCAGCTGTCGCCAAACAAATGAAAAGCGCCTGGCTTGCATTAAAATCG
Seq A exon
GTAAAAAAAAAATCGGAAATGTGCACAGGCATCCAGCGAATGCAGCGACCTATTCGCCGGCGTCGGGACGCCGCCAGCTGAAACTGCACGGTCGAATTTGGCTGCATTTGCACAAACGCTGTGCTGACGCGGGGAAATGGGAGCATAAAAACCGAAACTTGTGTGCGAAATATGCGAATATGCGAAACCTTGGCTCCCAGTGCGATCTATGTGTGTGTGTGTGTGAGCCGTGCTGTGTGTCGGTGTTGCAGAACGAACCAAGTGGGAAGCAAAGCGAGAGAAGACGAAGAGGAAGAAAAAGAGCCGCTTGTACCTGCTCCGAAAACTGAAACATCCGAAATCGGAGGTGAAAAGGTGCTCTGATAGTGTTTAGCTGCAGTTTTAGGAGATGCAAACTGGTTAATTGCTACGTAACGCTATTTTTCCGCTAAATTACTTCACCACCCCTTCTTCTACGTTCAGCGGTGACTTTGGCTTAAGAAAATGAAAATGTGTGGCCATATTTTTTCCTCTCCGTCTTTCTTTCGCCTTCGCGCTCTCCCTTTTGAAACTCTCGCCGCGCGCTGTTCTCGCCGCCTCCGTTTTGTGCCGCACTTCCGAGATAAAGAACGCAAACGCGAGATAAATGCGAAATATTGTATCTGAGGAGCGAGGCAACATACTCATTGTTCTCATCGATTTGTTTTGTCCGACAG
Seq C2 exon
AAAAGTGCATTGCATCCGAAAAGCGAATATCCAGTATCCAATATCCATTATCCGAAAGCAGCTAATTACCGACAGACAAGGAATTATTTAGAGATCGCCGCCAAAATGTCGGAGGAAGTAGATCGCAACGATCCGGAGCTCAAGTACCTCTCGGTGGAGCGCAACCAGTTCAACGATCCGGCCACGCAGGCCGAGTGGACACAGAAGCGTCTGGTGTGGGTGCCACACGAGAACCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265434:FBtr0072399:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.179
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF0273614=Myosin_N=PU(23.3=22.7)
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0072306
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0072305, FBpp0099894, FBpp0099896, FBpp0291728, FBpp0291729, FBpp0291730, FBpp0291731, FBpp0297531
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAAGCGGCGAAAAACAGTGAA
R:
GACGCTTCTGTGTCCACTCG
Band lengths:
349-1044
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)