GgaEX0015492 @ galGal4
Exon Skipping
Gene
ENSGALG00000010361 | MBNL1
Description
Muscleblind-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q5ZKW9]
Coordinates
chr9:22851960-22856458:-
Coord C1 exon
chr9:22856305-22856458
Coord A exon
chr9:22852750-22852785
Coord C2 exon
chr9:22851960-22852054
Length
36 bp
Sequences
Splice sites
3' ss Seq
TTGCAATGCATGATGGGCAGGCT
3' ss Score
0.74
5' ss Seq
TTGGTAGGT
5' ss Score
7.03
Exon sequences
Seq C1 exon
GGAATTCCTCAAGCTGTACTTCCCCCATTACCAAAGAGGCCTGCGCTTGAAAAAACCAATGGTGCCACCGCAGTGTTCAATACTGGTATTTTCCAATACCAGCAAGCTCTTGCCAACATGCAGCTGCAGCAGCACACAGCCTTTCTCCCACCAG
Seq A exon
GCTCAATATTGTGCATGACACCCGCTACAAGTGTTG
Seq C2 exon
TTCCCATGGTGCACGGTGCTACGCCAGCCACTGTGTCTGCAGCAACAACATCTGCCACAAGTGTTCCCTTCGCTGCAACAGCCACAGCCAACCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSGALG00000010361_MULTIEX1-5/7=4-6
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (disopred):
C1=0.125 A=0.346 C2=0.969
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CAAGCTCTTGCCAACATGCAG
R:
GGGAACACTTGTGGCAGATGT
Band lengths:
120-156
Functional annotations
There are 5 annotated functions for this event
PMID: 17702765
C-terminal region, partly encoded by exon 7, mediates homotypic interactions which may stabilize int... [Show more]
PMID: 27733504
The presence of alternative ex.54nt always significantly elevated MBNL1 and MBNL2 protein levels (_2... [Show more]
PMID: 29955876
Inclusion/exclusion of the exon affects splicing activity with sequential binding motifs, as shown b... [Show more]
PMID: 30456384
Exon 7 is the most differentially included exon in cancer, both in cell lines and in patients' sampl... [Show more]
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]