HsaALTA0005625-1/2 @ hg19
Alternative 3'ss
Gene
ENSG00000204475 | NCR3
Description
natural cytotoxicity triggering receptor 3 [Source:HGNC Symbol;Acc:19077]
Coordinates
chr6:31556853-31557410:-
Coord C1 exon
chr6:31557303-31557410
Coord A exon
NA
Coord C2 exon
chr6:31556853-31556953
Length
0 bp
Sequences
Splice sites
5' ss Seq
AATGTGAGT
5' ss Score
7.8
3' ss Seq
TGAACTTTCCCTTCCACCAGGTC
3' ss Score
11.22
Exon sequences
Seq C1 exon
AACATCCTCAGCTAGGGGCTGGTACAGTCCTCCTCCTTCGGGCTGGATTCTATGCTGTCAGCTTTCTCTCTGTGGCCGTGGGCAGCACCGTCTATTACCAGGGCAAAT
Seq A exon
NA
Seq C2 exon
GTCTGACCTGGAAAGGTCCAAGAAGGCAGCTGCCGGCTGTGGTCCCAGCGCCCCTCCCACCACCATGTGGGAGCTCAGCACATCTGCTTCCCCCAGTCCCA
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000204475-6-7,6-6-1/2
Average complexity
Alt3
Mappability confidence:
NA
Protein Impact
Protein isoform when splice site is used (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.083
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GTCAGCTTTCTCTCTGTGGCC
R:
GATGTGCTGAGCTCCCACATG
Band lengths:
136-191
Functional annotations
There are 1 annotated functions for this event
PMID: 21552268
This event
[Negative results]. Depending on which exon 4 is translated, the immunoglobulin domain (which is either a V- or C-type domain, but forms containing the V-type immunoglobulin domain are largely overrepresented) can be linked to any of three distinct intracellular domains (which have 36, 12 and 25 amino acid residues), giving rise to three isoforms: NKp30a, NKp30b and NKp30c, respectively. NKp30 isoforms have contrasting effects and can be functionally classified as two immunostimulatory isoforms (NKp30a, NKp30b) and one immunosuppressive isoform (NKp30c). Overexpression of NKp30a or NKp30b, but not NKp30c, increases IFN-gamma levels. Isoform distribution is prognostic for gastrointestinal tumors. A is distal and long ALTA, B is distal and short ALTA, C is proximal APA.
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)