HsaINT0000039 @ hg38
Intron Retention
Gene
ENSG00000175899 | A2M
Description
alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7]
Coordinates
chr12:9079639-9080177:-
Coord C1 exon
chr12:9080094-9080177
Coord A exon
chr12:9079816-9080093
Coord C2 exon
chr12:9079639-9079815
Length
278 bp
Sequences
Splice sites
5' ss Seq
TGGGTGAGT
5' ss Score
8.73
3' ss Seq
CCATCTCTCCCATTCTCTAGGAG
3' ss Score
9.93
Exon sequences
Seq C1 exon
GTGGTGAGGTTTCTGAAGAATTATCCCTGAAACTGCCACCAAATGTGGTAGAAGAATCTGCCCGAGCTTCTGTCTCAGTTTTGG
Seq A exon
GTGAGTCTCCAGCCCCTAGTGGATCCGGGCATTAACAGCTTCTATTATACTATTTTTATTTCCCATAAATATTTACTAAAAATAATACTATAATTTTAACTTCTTTCTTCTCTTCTTCTTTGGGCTTGTTTATTGCTTTCAATCATACTTCTATCCCTGGAAGAATCATCCTTCCTAAAAATTCTCAATTTCTAAGCTCAACTAATTATTTCTGCTTAATGACTTTGATAGATGATAATCTCCAAGCTTTATGACTTCCCATCTCTCCCATTCTCTAG
Seq C2 exon
GAGACATATTAGGCTCTGCCATGCAAAACACACAAAATCTTCTCCAGATGCCCTATGGCTGTGGAGAGCAGAATATGGTCCTCTTTGCTCCTAACATCTATGTACTGGATTATCTAAATGAAACACAGCAGCTTACTCCAGAGATCAAGTCCAAGGCCATTGGCTATCTCAACACTG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000175899:ENST00000318602:23
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.069 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
PF105694=Thiol-ester_cl=WD(100=51.7),PF076789=A2M_comp=PU(0.4=1.7)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGGTGAGGTTTCTGAAGAATTATCCC
R:
AATGGCCTTGGACTTGATCTCTG
Band lengths:
244-522
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Genotype-Tissue Expression Project (GTEx)
- Autistic and control brains
- Pre-implantation embryo development