HsaINT0002222 @ hg38
Intron Retention
Gene
ENSG00000157766 | ACAN
Description
aggrecan [Source:HGNC Symbol;Acc:HGNC:319]
Coordinates
chr15:88840012-88841867:+
Coord C1 exon
chr15:88840012-88840186
Coord A exon
chr15:88840187-88841739
Coord C2 exon
chr15:88841740-88841867
Length
1553 bp
Sequences
Splice sites
5' ss Seq
CAGGTGAGC
5' ss Score
9.6
3' ss Seq
CCATTTCGGGTTCCTGGCAGATA
3' ss Score
8
Exon sequences
Seq C1 exon
GCATCGTGTTCCATTACAGAGCCATCTCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCCATCATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGACGCCGGCTGGCTGGCTGACCAGACTGTCAG
Seq A exon
GTGAGCCCTAGCCCATCAGCTAGTGGGGGCCAGGAGTCAGCAGCCACAGGGGAGTGGGGCGGGTGCTGGGTGGAACGTTGGCCAGCACTGAGCTGGTGCCAGCATGACACTGTGGCCAGCCTAGGTTAGAGGCCGTGGTCACACCTTGGCCAAACAGCAGCTCAATGACCCATCCCAAACCCTTGTTATTGTGATTCTCTCTTGCAAATGGGATGAGGGACTGCTAGCAACCTTGCCCTACATGTCATTATTTTTCCTACCCATTTTTTTCTTTGCCATGATTTCCTCACGTTTAAACTTTGGTGTCCTCTGTATTTTTATAAACAAACTTCCATCCTTTTTGTTTTTAATAAGGCAAGTTATAAATTGAACCCCTTGGTACATCCTTCCCTGAGCGTAGTTGCTGAGGAGTGAGGTGCAGAGCAGTCCAGATAGACCCTGCCCTCAAGGGATCTCAATGCACTGTGAAGGCAAGATGATATCACCCATTTCAGGAGCATCATAGCTCCAACAGCCAAAAACACAAAGCCTCAGGAAGGAAAATGTCTTTGCAGTCTCGGGGTAGGAAAACAGATCTTAGGATACAAAAACTATAGCCATAAAAAAAAAAAAAAGATGAGATAATAGTCTAGCATAGAGCAAGAGCCCACACCTGGGGGCATAAAGAACTGGACTCAGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACGAAGTCAGGAGATCGAGACCATCCTAGCTAACATGGTGAAACCCCATCTCTACTAAAAAATACAAAAAATTAGCCAGGCGTGGTGGTGGGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTAGGTGACAGAGCGAGACTCCGTCTCAAAAAATAAAAGAACTGTACTCAAATTCCAGCTCTGGCACTTGGAAGCTGCGTGACTGTGGACAAATGATTTAACACCTCTGAGCCCCAGTTTCTTCAAGTGTAAAGTAGATTGATGATAGCACCTACCTCACTGGGTTGACATGAGACTCAAATGATATAGAGTGAGGCCTAACAAACTATGGCCCAGAGGCCAAGTCCAACCCACCCCTTGCTTCTGTAAATAAAGTTTTATTGGGACACAGTCACACCCATTTGCATATCTGTGGGTGCTTCACGCTACAGTGGCAGTTGAGTGGTCACCACAGAGACTATGCAAAACCTAAAATATTTACTATCTTGCCTTTTATAGAAAAAAATATGTGAGCCCCTGATAGAGAAAGTGTGTTTTGTACCACTAAATATTCAGTAGTGGGGGCTGCCTTTAATCATGATTCACTGTAAAAACAGATAGGCAGTTGACATATTCAGAAGAGACATTGTCAAATGCAATATTAAGTTGCTGTTTCCTCCCACGGGAGGAGGATTCAAAGGCAGAGGCCATGGGCTTCCCTTTGTCCCCTGAGTGTCACACCTCCATTTCGGGTTCCTGGCAG
Seq C2 exon
ATACCCCATCCACACTCCCCGGGAAGGCTGCTATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAGACCTATGATGTGTACTGCTTCGCCGAGGAGATGGAGG
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000157766:ENST00000558207:4
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0019312=Xlink=PU(60.4=98.3)
A:
NA
C2:
PF0019312=Xlink=PD(38.5=84.1),PF0019312=Xlink=PU(0.1=0.0)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Rat
(rn6)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCATCGTGTTCCATTACAGAGC
R:
CCTCCATCTCCTCGGCGAAG
Band lengths:
303-1856
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development