HsaINT0137393 @ hg19
Intron Retention
Gene
ENSG00000091428 | RAPGEF4
Description
Rap guanine nucleotide exchange factor (GEF) 4 [Source:HGNC Symbol;Acc:16626]
Coordinates
chr2:173861194-173866072:+
Coord C1 exon
chr2:173861194-173861282
Coord A exon
chr2:173861283-173865993
Coord C2 exon
chr2:173865994-173866072
Length
4711 bp
Sequences
Splice sites
5' ss Seq
CAGGTATAC
5' ss Score
7.48
3' ss Seq
CTGTTTTTTTCCCCTTCCAGATT
3' ss Score
12.78
Exon sequences
Seq C1 exon
GTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAG
Seq A exon
GTATACACATAGAACCGTTTGCATGTCCATTAAATCCATGCATAGCATTGTTTAAAAGTCCTGAATTCATTTGCAGTGTGTATAGCGAAAGCAGTTTGGGAAGGGGATTCTGTGTATTGATATTTGAAAAGCATCTCTGTGTGACCTGACTGGGAACAGTCCTTCTGACTGTCGTCTTCCCTCCCCAATCCTGACTGTTCTCTAGAAATGACTCAGCCTCATTTCTACATACTATGCCTCATCTTCCCTAGGCATCTCTCTCTTAAGTTATTCAAATCCCACCTTCTATAGGCATCTATTGGGTTTATCATACATCCTACCTATTCCCACGAAGGATTTGAAGCTGCCTACATAAAAGGTACAGCCTTGCTCCAGTTGGGAGTAAGATACTTCTCTCTGCAGTTGTTGTAGAGTCCAGCTGCTCTAGAATATAACTAAATGCCACCATTCGTTTGCTAGGGCTGCCCTAATGAACTACCACCAACTGGGTAGCTCAAGCAACAAAATTATATTGTCTTACAGTTCTAGAGGCTAGAAATCCTAGCTGAAGGTGATATTTGGGTTGGTTCCTTTTGAAGGCTGTGAAGGAGAATCTGTTCCATGCCTCTCTCCTAGCCTCCTGTGGTTTGCAGGCTATCTTTGGCATCCTTTGGCTTGTAGATGCATCATCCGGATCTCTGCCCTCATGTTCACACAGCATTCTCCCTGTGACTCTTCACATAGCCTTCCCTCTGTGCCTGTCTGTCTCTGGGTCCAAGGTTACCCCTTTTTATAAGGATGGCAGTCATATTGGATTAAGGCCCTCATTAAGGACCTCACCTTAACTTGACCACATCTGCAAAGACCCTATTTCCAAAGACGATTATATTCTGAGATACTGGAGGTTAGTTCTTCAACATATCTTTTTGGGGGGATACAATTCAACACATAACATCTGCTTACAGTGAGTCAGTCTTGTTACCTAAGACACAGAAATTCTAGGGTGAATAAAACAAATCTCACCAGTGAACTAAGTGTTCAGAGTTATAAAATTGTGTTCCACTTTGGTTACCATCTTGTATATGACTTTGCAACAGCCCACACGCAACGTGTTTTTTTTTTAATCCTATGCTACTGCCTGTCTCTCAGAATAATGTTGTGGGTTAATATTTTAAGCACATTGAGCTCCATAGAAGAGCCTTTCTCACTAAAAGAAGTTCAGAGATTTATCTCAAAAACTTAGTTCAAAATCCATTTCCATAATTGACCTTTGCTATATATTCAAGTTGAAGATATCATTATTATTATTATATACCTCCTAAAGGTATTTTACCACTGAATTCTTATTTTATCTTCTCATTCCAGTTTCTCATTTTATACATAGATTACCTGAGGTTTTTTATGTAGCAAATTAATTAGGGTATAGTAGATATAATCGTCAGGATCACTGGCTCCAGGCCAATTATTCTCAGGTCAATATTTGTTGAGTATCTTGTTGGGCAGACACTAAGCTAGATGCTTTGGACTAGGCAATGTGAACAAGGAATCATTCTCCTGCCTTCAGGAAGCTTATAATCTGTTAGAAGACATAAAGGAATGTGCACATAACTTGAATATAAGGCAGAATGTGGTTAGTGCTTCAGGGACACTGACTAGGTGAGGGATCTAGAAAAGTATCATGGAAAATATAGAGTGGCCCTGAAGGAGGCTGGTAACCAGTAATTAGAGATAGGGACAAAGCCATCCATACTAAGGGATAATATTAGCACTGACCTAGAAATAGACAGGGAAGAGTGAGTGGTCGGATTTTTACTGGACTATTGTATACGTAAGTTGGAAAACGAAGGAAAGGTTTAAGAATTGGGGTATAGATCTTAGAGAGTCTTAAATGTAAAGCCGGCTGGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGGGCCAAGGCGGGAGGATCACTGGAGCCCAGGAGTTTGAGGCTACAGTGAGCTATGATCATGCCACTGCACTCCAGCTTGCACAACAACAACAAAAAGGTAGAGCCAAGCACTGGGAAGTGGTTGAAGATGTCTGAGCAAGAAGAACATGATAAGAACTATGCTGGAGAAAAGTTACTCCATATTTAGTATAGAGAAACTGTTGAAGAACCGGTTATGTGAGGATAGCTACCAAGAGCCATATGTAACCTCAAATAAACCAAATTTCCAGGACCATGGGTCAGGAAAAAATGCAGCTGATTTTTTCCCTCTGATTAACTGTTTGCCCAGAATGTGTGATTGCATAATGCAAGAATCAGCATCTTACCTAAGGTATATATTGACTCAAAAAAATATATATTCTGGTACATTAGAGACTGTGGCATCTAAGGAATGAGCTATAAGATCTTTACCACCCATGAAGGGCAAGTATAGCCTTCCTTTCAAGTCACCTCTAAAAGAGATGGAGATTGGATTATTGCTGCTGCTTCTGCTTCTTTTGTTTAGTTTTGTTTTTTTAATTACTGTTCCTTGCAGAGCAGGGCTAACCCATGGGCAGTGTGCCAAGAGTAGCCTGATTATTTCTTCTTCATCAAAAAAATTAAAGCCTAGAAATCAGTGTATTCTAAGGCTGGCGTGTGGGATGTGATTCTTGACCCTTCCATTTTTGATGGTAGAGACTAGGCTAACATCATAATTTAATATTGAACTTCATTTCCTGCAGTTTTTCCTGATATTTTTTTCCTACAAGTAATGTTTATGCCTTGGAGATAAAGAACAAACCAGTATCTTTCTCATAAATCAGAAATACAAATGTGCCTCCCTCCTGTCCTGGACACTAAATAATCCTAGGGTAGGTCCACGAAATTTGTGGATATACCAGAGTAGGAGACCTTTGGCAGTTATAGATTTACAGTACAGTAAGAAAGGTCAGAGTTACCGTGAAAGTTGTTTACATCATAAAAATGCACACTGCTGAATTTGACATTACACTCTCTTAATTTACCAAAAATCTGTTTTCTACCTGAGACCTATTAGTTCTTATATTTTTACTTTTAAAACCAGCATTAGTCATGGAGTGACTTGGTAAATCATCTTCTAGTAGGAAGTGATGTTTTAAATTAGTTCTTAAGCAAATTTTAACCTATAAATTAGATTTCCAGTGTTCATGTTTTTGATGAACTTACATTGGCAAAGTCTGAATCAGTGACTAAATGTTTAACCATGATTCTCATTTAAATATAAGTGATGAGTGTAATCCCAAGCTGTCATCACTCAGTGTCACCAGTCACCTTCAGTCTCATTATACTGAGAAGCAGAGAAGGTGCCAGACAGAAGAGTTGCTACATGTGAGGAGAGAGCCGGAAAGCCACACTGAAATGTGAGCTGAGTGGTTGGCCATGTTAACTGACTCCCTCCCCAGCCTTGGAGCACCCAAGTCAAGTCTCTGCTTTAGCAAACTTTAAACTACTGGATATTACAGCCTCCTGGGTGCATATAAGCAAGTATTACCTACTCTGTTCTCAAGAATATATAAAACATATCAAGATGGTGCTAGATGTTAAGCTCAGGCAAGCCAAAATCCTTTGGTACATTAAAAAAAATATTTTCTTGCAGCCTCTGTCTGACACCTTCTCTGCTTCTTCTCTGGCTCAGTATAACGGGACTGAAGACCTGGTGACATTGAGTTGTGACAGCTTGGTATTACACTCATCAGTTATATTTAAATGACTATGTATAATGGTTAAACCTTTAGTAACTGACTCAGACTTCACCAATAAAATTTCATTAAAAACATGGACAACATTTGGCAATCTAATTTATAGCATTAAAATGTACGTATTTCTCACCATTTTCCATTTAAGATGAGCGTCACAATCTCAGACAGTGTATTTCATGTTTTCCCGGGAAATGTCATGGCATCTTGGGTTCCAAGTTCTGATGGGCATAGTCCTGAGGTTTTTAGGTTTGCCTTCATGAGCTTTCCCATCTGGCTAGCCAGGGCATGTTGTCTGCAATGAAGAACCAGCATCAAATTCAATGATGAAGTAAATGAAGCTTATTTGGGGGACCTGCCTTACTTCCCTTGCCAACCCCCTGCTTCCTTACCTACAAAATAGTTTCACATATAGGACAGTCACCATTTGAATCCACCAGCTTCTGTTTTGTTAGCCTTTGTTTTGCTCTAGTTGCTGCTCACAGCCTTAATCTTGTTTTCTTTCTTTCTTTTCTTTCTTTCTTTTTTTTTTTTTTTTGCTGCTTCTTTCTCCCCTCACCAATTCTCTGCTCTTACCACGTCCTGATTCTGTAATTCTATTGTCCTCCTACCTTTCATTGCTTCTTTTGGAAATAGGAGGTGAAAAAGACATAAAAGAGAAAGGATTTTGAAAAAACAAATACGGTATAGACAAAGAAACGACCATGTCTTCGTTCTGCATGTATGGTACTGCCCACATGTGACCCTTTAAGTACACAGATTTTAAAATCTTTGGTGGCTAAGGTACCCAGTGCCGTTTGTACAAGGCTGTCTCTCTTTAAAATATTATACTTTTTGTCCATTGTCATAAGAAACTGATTTTCATCTCAATCTCTGTCAACACCATTATTTATATGAAGTGCTTCCATGTAAAGTAAACTCATGCCCCAAACCAATGTGTTAGAACCAATGACTAAGAACAAGTGAATGGATACTCTTGCTTTCCTAAAGATTTCCACAAGAACCTAATTTCCTTTTCTGTTTTTTTCCCCTTCCAG
Seq C2 exon
ATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCA
VastDB Features
Vast-tools module Information
Secondary ID
ENSG00000091428-RAPGEF4:NM_007023:16
Average complexity
IR-S
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.161 A=NA C2=0.000
Domain overlap (PFAM):
C1:
PF0061815=RasGEF_N=PU(26.2=90.3)
A:
NA
C2:
PF0061815=RasGEF_N=FE(24.3=100)
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
No suggested primer sequences
R:
No suggested primer sequences
Band lengths:
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Autistic and control brains
- Pre-implantation embryo development
Other AS DBs:
FasterDB (Includes CLIP-seq data)
AS-ALPS (AS-induced ALteration of Protein Structure, links to PINs)
APPRIS (Selection of principal isoform)
DEU primates (Only for human)