MmuINT0128546 @ mm10
Intron Retention
Gene
ENSMUSG00000047250 | Ptgs1
Description
prostaglandin-endoperoxide synthase 1 [Source:MGI Symbol;Acc:MGI:97797]
Coordinates
chr2:36230426-36230763:+
Coord C1 exon
chr2:36230426-36230569
Coord A exon
chr2:36230570-36230667
Coord C2 exon
chr2:36230668-36230763
Length
98 bp
Sequences
Splice sites
5' ss Seq
GTCGTGAGT
5' ss Score
7.82
3' ss Seq
ACTCTCTCTTCCTTCTGCAGGAA
3' ss Score
12.88
Exon sequences
Seq C1 exon
AGAGGTGACAACTGGAGGGAGGAGTGGGGGTGGAGCCGTGAGATGGGTGGGAGGGGACCTGCCAGTGCTGGGGCAGTGCTGGAGTTGCACCCGAGGAGCCAGCCGTTGGCATTGCACATCCATCCACTCCCAGAGTCATGAGTC
Seq A exon
GTGAGTCCGACCCCAGTGGTGCCCCCACGCGTCCCGGAATTCGGTGGCCTGCAGGCGGAGCCTTGAACGCTAGGCTCAACTCTCTCTTCCTTCTGCAG
Seq C2 exon
GAAGGAGTCTCTCGCTCTGGTTTCCCCTGCTGCTGCTCCTGCTGCTGCCGCCGACACCCTCGGTCCTGCTCGCAGATCCTGGGGTGCCCTCACCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000047250:ENSMUST00000062069:1
Average complexity
IR
Mappability confidence:
NA
Protein Impact
ORF disruption upon sequence inclusion (1st CDS intron)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Other assemblies
Conservation
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Fruitfly
(dm6)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AGAGGTGACAACTGGAGGGAG
R:
AAACCAGAGCGAGAGACTCCT
Band lengths:
167-265
Functional annotations
There are 1 annotated functions for this event
PMID: 12242329
Comparison of canine COX-3 (with IR) activity with murine COX-1 and -2 demonstrates that this enzyme is selectively inhibited by analgesic/antipyretic drugs such as acetaminophen, phenacetin, antipyrine, and dipyrone, and is potently inhibited by some nonsteroidal antiinflammatory drugs. [in Stamm et al, wrongly cataloged as soluble variant]
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Pre-implantation embryo development
- Ribosome-engaged transcriptomes of neuronal types
- Neural differentiation time course
- Muscular differentiation time course
- Spermatogenesis cell types
- Reprogramming of fibroblasts to iPSCs
- Hematopoietic precursors and cell types