DmeALTA0006578-3/3 @ dm6
Alternative 3'ss
Gene
FBgn0261461 | RhoGAP18B
Description
The gene Rho GTPase activating protein at 18B is referred to in FlyBase by the symbol DmelRhoGAP18B (CG42274, FBgn0261461). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (3 unique). Gene sequence location is X:19136107..19167082. Its molecular function is described by: GTPase activator activity; Rho GTPase binding. It is involved in the biological process described with: actin cytoskeleton organization; signal transduction; positive regulation of GTPase activity; regulation of GTPase activity. 71 alleles are reported. The phenotypes of these alleles manifest in: trichogen cell; mesothoracic tergum. The phenotypic classes of alleles include: phenotype; increased mortality during development; flight defective; visible. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages.
Coordinates
chrX:19164151-19167082:-
Coord C1 exon
chrX:19166857-19167082
Coord A exon
chrX:19164686-19164860
Coord C2 exon
chrX:19164151-19164685
Length
175 bp
Sequences
Splice sites
5' ss Seq
CCAGTGAGT
5' ss Score
8.28
3' ss Seq
CCAACCCAATTTCTTTTCAGTGA
3' ss Score
6.81
Exon sequences
Seq C1 exon
TTAGTCGCCTGTCAACCGCCGTCCCTTTCGATTTGCCCATTCGGTTTCGTTGATTTGCTGTTGATTCTGAGCTGATTTTGAGTTGTTTTAATGTGATGCGATGCATTTAATTGAGGCGCGTACGTGACGTTTGCAGATGCGCTTGCTGTTGCATCTTTGCCACTGCATCAATAGTCGGCTATCAGTGGTCAGCTATTGGAATTGCCAATGCACTTGCTGCTGGCCA
Seq A exon
TGAATCCCTCCCACACAACACAAAAACGCCATAAAAACAAAAGAGTTAACAAAACGCAACCATAAACCAATGAGTTTAAAGTGAAAGAGTGAAGAATTAGGAAAGAGCAGAATCGTGCAGATTTCGAGTGTGTGATATCTGTTTTGTTTTTTTTTATTAGTTTTTTTTTGCACAG
Seq C2 exon
TGTGATCATGGCCGGCGATACGGAGAACAAAAGGGGCTATCGCACCATATTTCGCAGCATATCCCAGGTGTTCTACGCCAATGCAAAAAACTCGAGTAATACGAACAGCAGCAGCAGTAACAACAACAATAATATCATCAACTACAACAACAACACCATCGAGAACAACAACGAGGGAATCGGCCAACTAACAGTTACGCTCACCAGCATAACACCACCCACAGCCACATGGACGTCGACATCGCCCACAATCTCCACGTGCACAACTGCGTCCGCATCGGCGGGATCATCCACCGCATCCTTGTCGCCACTGGCTAGCAGATCAGCGCGATCGGCGGAGAATATATCCTGCAGCGAGTGTGGAAACCCAGATCCGTATCATGGCCAGGACATGGAGTTGGCAAAAGGTCAAGCCCTGACTCCCGAAGTGCCAGCAGTGCCGGTTCCAGCTGCCAGTGCGGATCAAAACCAGAAGCTAAGGGCCAGTTCCATGCTGGATC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261461-0-3,0-2,0-1-3/3
Average complexity
Alt3
Mappability confidence:
NA
Protein Impact
5' UTR
No structure available
Features
Disorder rate (Iupred):
C1=NA A=NA C2=0.847
Domain overlap (PFAM):
C1:
NA
A:
NA
C2:
NO
Main Inclusion Isoform:
NA
Main Skipping Isoform:
FBpp0288897
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0288900, FBpp0308368
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTGCCCATTCGGTTTCGTTGA
R:
TGCTGCGAAATATGGTGCGAT
Band lengths:
253-428
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)