Special

DmeALTA0008760-2/3 @ dm6

Alternative 3'ss

Gene
FBgn0000038 | nAChRbeta1
Description
The gene nicotinic Acetylcholine Receptor beta1 is referred to in FlyBase by the symbol Dmel AChRbeta1 (CG11348, FBgn0000038). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3L:4429349..4435993. Its molecular function is described by: acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; neurotransmitter receptor activity. It is involved in the biological process described with 6 unique terms, many of which group under: signaling; cellular process; synaptic signaling; cell communication; anterograde trans-synaptic signaling. 15 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: viable; partially lethal - majority die; some die during pupal stage; short lived. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chr3L:4432386-4433459:+
Coord C1 exon
chr3L:4432386-4432522
Coord A exon
chr3L:4433305-4433367
Coord C2 exon
chr3L:4433368-4433459
Length
63 bp
Sequences
Splice sites
5' ss Seq
GTCGTAAGT
5' ss Score
9.9
3' ss Seq
AAAATCGAAAACCGATCAAGAAT
3' ss Score
-5.38
Exon sequences
Seq C1 exon
TCAGTGCATCCGAAGATGAAGAGCGCTTGGTGCGTGACCTCTTTCGAGGCTACAATAAACTCATACGACCCGTACAGAATATGACACAAAAAGTTGGAGTAAGATTTGGTTTGGCGTTCGTACAGCTAATCAATGTC
Seq A exon
AATGAGAAAAATCAAATTATGAAATCAAACGTTTGGTTACGTTTGGTTTGGTACGACTACCAG
Seq C2 exon
CTGCAGTGGGATGAGGCCGACTACGGCGGCATCGGGGTGTTGCGTCTGCCCCCCGACAAGGTTTGGAAGCCGGACATTGTGCTCTTCAATAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000038-4-8,4-7,4-6-2/3
Average complexity
Alt3
Mappability confidence:
NA
Protein Impact

Protein isoform when splice site is used (Ref)

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=NA C2=0.000
Domain overlap (PFAM):

C1:
PF0293118=Neur_chan_LBD=PU(18.7=84.8)
A:
NA
C2:
PF0293118=Neur_chan_LBD=FE(24.4=100)


Main Inclusion Isoform:
FBpp0073155


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAGATGAAGAGCGCTTGGTGC
R:
TAGTCGGCCTCATCCCACTG
Band lengths:
148-211
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)