Special

DmeALTD0000082-1/2 @ dm6

Alternative 5'ss

Gene
Description
The gene Abl tyrosine kinase is referred to in FlyBase by the symbol DmelAbl (CG4032, FBgn0000017). It is a protein_coding_gene from Dmel. It has 11 annotated transcripts and 11 polypeptides (9 unique). Gene sequence location is 3L:16615866..16647882. Its molecular function is described by: protein tyrosine kinase activity; protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding. It is involved in the biological process described with 28 unique terms, many of which group under: protein localization; cell migration; lamellipodium organization; regulation of protein stability; chemical synaptic transmission. 59 alleles are reported. The phenotypes of these alleles manifest in: multidendritic neuron; cellular anatomical entity; embryonic/larval cuticle; actin cytoskeleton; amnioserosa. The phenotypic classes of alleles include: increased mortality during development; some die during embryonic stage; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages.
Coordinates
chr3L:16615866-16626616:-
Coord C1 exon
chr3L:16626528-16626616
Coord A exon
NA
Coord C2 exon
chr3L:16615866-16625274
Length
0 bp
Sequences
Splice sites
5' ss Seq
ATGGTATAC
5' ss Score
2.73
3' ss Seq
TTAACCATTCACTTTGGCAGGAC
3' ss Score
6.21
Exon sequences
Seq C1 exon
CCTGCTCTCGAGCAGTCGGGACTCCACTTATCGCGAGGAGGATCCAGCCAACGCCAGATGCAATTTCATCGACGACCTCAGCACGAATG
Seq A exon
NA
Seq C2 exon
GACTAGCCCGGGACATCAACAGTTTGACGCAGCGGTACGATTCCGAAACAGATCCGGCAGCCGACCCGGACACAGATGCCACGGGCGATAGTCTGGAGCAGAGTCTGAGCCAAGTGATAGCCGCTCCGGTCACCAACAAGATGCAGCATTCTCTTCACAGCGGAGGAGGAGGAGGAGGAATAGGTCCTCGATCCTCGCAGCAACACAGCTCCTTCAAGCGACCGACTGGAACACCCGTGATGGGTAACCGAGGACTAGAGACCCGGCAGAGCAAGCGGTCCCAGCTCCATTCACAGGCTCCGGGTCCAGGACCGCCATCAACTCAACCGCATCATGGCAACAACGGCGTGGTGACCAGTGCTCATCCCATCACTGTGGGTGCGCTCGATGTGATGAATGTCAAGCAGGTGGTGAACCGCTACGGAACACTACCAAAGGGTGCCAGAATCGGTGCCTATCTGGACAGTCTTGAGGATAGCAGTGAGGCTGCTCCTGCTCTT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000017-10-9,11-9-1/2
Average complexity
Alt5
Mappability confidence:
NA
Protein Impact

Protein isoform when splice site is used (Ref)

No structure available
Features
Disorder rate (Iupred):
  C1=0.791 A=NA C2=0.871
Domain overlap (PFAM):

C1:
NO
A:
NA
C2:
PF089195=F_actin_bind=WD(100=13.2)


Main Inclusion Isoform:
FBpp0303169


Main Skipping Isoform:
FBpp0303166


Other Inclusion Isoforms:
FBpp0075116, FBpp0111702, FBpp0303167, FBpp0303168, FBpp0311523


Other Skipping Isoforms:
FBpp0303163, FBpp0303164, FBpp0303165
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GAGCAGTCGGGACTCCACTTA
R:
TCGCTTGAAGGAGCTGTGTTG
Band lengths:
301-556
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)