DmeALTD0004661-2/2 @ dm6
Alternative 5'ss
Gene
FBgn0261046 | Dscam3
Description
The gene Down syndrome cell adhesion molecule 3 is referred to in FlyBase by the symbol DmelDscam3 (CG31190, FBgn0261046). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3R:17473935..17505667. Its molecular function is described by: identical protein binding; cell-cell adhesion mediator activity. It is involved in the biological process described with: homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; dendrite self-avoidance. 17 alleles are reported. The phenotype of these alleles manifest in: commissure. The phenotypic classes of alleles include: viable; neuroanatomy defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed during early larval stages, at stages throughout the pupal period.
Coordinates
chr3R:17475080-17475917:-
Coord C1 exon
chr3R:17475653-17475917
Coord A exon
chr3R:17475644-17475652
Coord C2 exon
chr3R:17475080-17475343
Length
9 bp
Sequences
Splice sites
5' ss Seq
CAGGTACCT
5' ss Score
8.16
3' ss Seq
CATTCCTCGACCATCTTTAGTTT
3' ss Score
4.16
Exon sequences
Seq C1 exon
ATATGTTCCGACCGGACTCCAGCACCGAGTCCAATAATGACCAGGGCTCGCCGGCGCCCGAGCGTCGACACAACACCCCACGCCACGTCCTAGGGATGGGCATGGCCATGGGCTTGGGTGGTGGTGGCGGTGGGGGCGTCGGTGGAGGCAACGGGCCGGCCGAGAAGCGGAGTGCCGGACAACGCAGCCGGAAGCACGGAAGCGCGGCACAGCAGCCTAGCAACCAAACGTTGGAGCGAAGAAAGTGCCCTGGTAGTAGCAACAG
Seq A exon
GTAGTTCAG
Seq C2 exon
TTTAGACAGTGAGGTCGATGCGGAGACCGCCGCCTCTTTGGCAGCCTCTATAGCCGCGATGGCGGGGTCGGGAGCGGGAGCCGACCTTTCCGGTGGTTTCCGCCCGCCGGCTGGATTCCACGATGGCCGGGAGCCGGGCGACCACAGCGATTGCGAGCGGGAACAGCGGGCGCTGGATCTGGAGGTGCAGCGCGTGATGGAGAGCACCGGGGACGCTCAGCTGGCCAAGATGGATCGCGAGGAGTTGACCTCACTGTTGGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261046-37-33,38-33-2/2
Average complexity
Alt5
Mappability confidence:
NA
Protein Impact
Protein isoform when splice site is used (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=1.000 A=NA C2=0.938
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
FBpp0112309
Main Skipping Isoform:
FBpp0303244
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0303245
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACGTTGGAGCGAAGAAAGTGC
R:
CGGCTATAGAGGCTGCCAAAG
Band lengths:
94-103
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)