DmeALTD0009147-2/3 @ dm6
Alternative 5'ss
Gene
FBgn0264089 | sli
Description
The gene slit is referred to in FlyBase by the symbol Dmelsli (CG43758, FBgn0264089). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (4 unique). Gene sequence location is 2R:15869495..15922118. Its molecular function is described by: Roundabout binding; heparin binding; calcium ion binding. It is involved in the biological process described with 21 unique terms, many of which group under: embryo development; positive regulation of cell motility; positive regulation of cell adhesion; positive regulation of response to external stimulus; exocrine system development. 79 alleles are reported. The phenotypes of these alleles manifest in: plasma membrane bounded cell projection; segmental subdivision of organ system; cell projection; larval multidendritic neuron; neuron projection. The phenotypic classes of alleles include: lethal - all die before end of prepupal stage; phenotype; cell shape defective; increased mortality during development.
Coordinates
chr2R:15873535-15874449:-
Coord C1 exon
chr2R:15874323-15874449
Coord A exon
chr2R:15874290-15874322
Coord C2 exon
chr2R:15873535-15873677
Length
33 bp
Sequences
Splice sites
5' ss Seq
CCGGTACAT
5' ss Score
5.7
3' ss Seq
CTCTTTCCTTCCACCCACAGCGG
3' ss Score
11.34
Exon sequences
Seq C1 exon
GAGCCGGTGGATCCTTGCCTGGAGAACAAATGCCGTCGGGGCAGTCGCTGTGTGCCGAATTCCAATGCCAGGGACGGCTACCAGTGCAAGTGCAAGCACGGCCAGCGCGGCCGCTACTGCGATCAAG
Seq A exon
GTGAGGGCAGCACTGAGCCCCCAACAGTCACCG
Seq C2 exon
CGGCGTCCACCTGTCGCAAGGAGCAGGTGCGCGAGTACTACACGGAGAACGACTGTCGCTCGAGGCAGCCGTTGAAGTACGCCAAGTGCGTGGGCGGCTGCGGCAACCAGTGCTGCGCGGCCAAAATTGTGAGACGGCGCAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0264089-21-20,22-20,23-20-2/3
Average complexity
Alt5
Mappability confidence:
NA
Protein Impact
Protein isoform when splice site is used (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.045 A=NA C2=0.007
Domain overlap (PFAM):
C1:
NO
A:
NA
C2:
NO
Main Inclusion Isoform:
FBpp0303578
Main Skipping Isoform:
FBpp0303574
Other Inclusion Isoforms:
FBpp0303573, FBpp0303575, FBpp0303576, FBpp0303577
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GAATTCCAATGCCAGGGACGG
R:
GTTCTCCGTGTAGTACTCGCG
Band lengths:
121-154
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)