DmeEX0000374 @ dm6
Exon Skipping
Gene
FBgn0259228 | C3G
Description
The gene C3G guanyl-nucleotide exchange factor is referred to in FlyBase by the symbol DmelC3G (CG42328, FBgn0259228). It is a protein_coding_gene from Dmel. It has 11 annotated transcripts and 11 polypeptides (9 unique). Gene sequence location is X:6780790..6803593. Its molecular function is described by: Ras guanyl-nucleotide exchange factor activity; Rap guanyl-nucleotide exchange factor activity. It is involved in the biological process described with 7 unique terms, many of which group under: regulation of GTPase activity; developmental process; regulation of catalytic activity; regulation of molecular function; biological regulation. 19 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical entity; wing vein L3; longitudinal muscle; hemocyte; imaginal tissue. The phenotypic classes of alleles include: partially lethal; phenotype; increased mortality; short lived. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages.
Coordinates
chrX:6784624-6786812:-
Coord C1 exon
chrX:6786156-6786812
Coord A exon
chrX:6785511-6785534
Coord C2 exon
chrX:6784624-6784735
Length
24 bp
Sequences
Splice sites
3' ss Seq
TCGTTCCAACCAACATCTAGTGT
3' ss Score
2.7
5' ss Seq
CGGGTAAGT
5' ss Score
10.75
Exon sequences
Seq C1 exon
GTTGGTGTCGCACAGCCAGCGTCATATATCCTCGAGCAGTAGCAGCTGCACCACCACGACCACCAGCAGCAGCACAACCACCGGCTATGGCAGCAGCGAAGTGGAGCAGCTGCAGCAGCAGCAGCAGCAGCAGACGACGACGACGCCGGCCGATCTGGCGCCCGCCTTGCCGCCAAAGAGCATCCAACGGAGCAGCCTAACCCGCCACGACTCGCCCGGAGTTGGCGATGAGCTGGACGAGGTGCAGTCCTCCTCCGGCTGGGCCAGCCATCGGAGCAGCCAGTCGGAGGTGGCCGAGCTGCGTCAGCTGTCGCCGCTCCATCACCTCAATCACCATCCGCATACTGCGTCCGCCGGTCAACTGCAGCAGTGGCACTCCAAGCACCACAGCCTGATCGAGGGACCCCGCCTCCAGCTGGCGGGGAGTGGCAGCTGCAGTGCGTTCGATCAGCGACACTTGGATCAGGAGCCACCGCCGCTGCCAATAAAAAAGAAGCACA
Seq A exon
TGTTTCAAAGTGTGGCCTTTTCGG
Seq C2 exon
TTCTGGCGTACATGGAAATCTGTTCGGCGTCCACGCGATCCATTGAGCAGCATCGTCACACAATGCACGCCTGCAACATAAGTCGCAACATCTCGCACAGCCAGACCATGAA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0259228_CASSETTE1
Average complexity
S*
Mappability confidence:
100%=100=50%
Protein Impact
Alternative protein isoforms (No Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.922 A=0.000 C2=0.640
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBtr0299792fB51
Main Skipping Isoform:
FBpp0289753
Other Inclusion Isoforms:
FBpp0306982
Other Skipping Isoforms:
FBpp0289069, FBpp0289070, FBpp0289071, FBpp0289072, FBpp0289073, FBpp0306980, FBpp0306981, FBpp0309086
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCAGCGACACTTGGATCAGGA
R:
GTGACGATGCTGCTCAATGGA
Band lengths:
112-136
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)