DmeEX0001196 @ dm6
Exon Skipping
Gene
FBgn0031170 | CG1718
Description
The gene ATP binding cassette subfamily A is referred to in FlyBase by the symbol DmelABCA (CG1718, FBgn0031170). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is X:21292308..21306665. Its molecular function is described by: ATPase activity; ATP binding; ATPase-coupled transmembrane transporter activity; lipid transporter activity. It is involved in the biological process described with: lipid transport; transmembrane transport. 8 alleles are reported. The phenotypes of these alleles manifest in: NMJ bouton; embryonic/larval neuromuscular junction; egg chamber; nurse cell. The phenotypic classes of alleles include: lethal - all die before end of P-stage; locomotor rhythm defective; viable; behavior defective; neuroanatomy defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes.
Coordinates
chrX:21298346-21300435:-
Coord C1 exon
chrX:21300151-21300435
Coord A exon
chrX:21299544-21299609
Coord C2 exon
chrX:21298346-21298934
Length
66 bp
Sequences
Splice sites
3' ss Seq
TGGCCACACAAAACCTGAAGACA
3' ss Score
-1.38
5' ss Seq
GAGGTAAAC
5' ss Score
7.2
Exon sequences
Seq C1 exon
ATCCATATTTTAACCAATTTTAATGTCGGGGTAATCTATAAAAACCCAAAAGCCAATCGAACAAATCTGCAAAATGGCAAAGGTCACAAACTGGGATAAGTTTGTGCTGCTTTTGTGGAAGAACTGGACCCTCCAATGGAACCACAAGTGGCAGATGGTTATAGAGCTGGTGCTGCCAGCGATATTCTCCCTGCTCCTCGTTCTAGTCCGCACCTTGGTGGATACGGAGCAAAAAGGAGTCCGGTATTATAATGAGCAGAACTTAACAGACCTCAATCTGCTGCA
Seq A exon
ACATTCGTTGCATAGATCGTCCTACCTTGGCAAGCTCATAGCGCTGATTGCACCCAATCGACGGAG
Seq C2 exon
GAAGAATGGCGGCTTTTCAAAATTTGAGTTCATCCTGTGCTACTCGCCCGTCAATCCCGTGTTGAAGAAACTGGTAGAAGAGGCGTGGCAGAGCCTTGGTAAGAACAAAATCTGTGAGTCGGAAAATGCCACCCAACTGGAGTTGGATACGGTCAGTAAGAACGCCTTTGCTGGCGTTCAGTTCGACGATGCCTGGGCGAATCTTACGGAGAATGACCCTCTACCCAATGACTTTCATTTCGCACTGAGATTCCCAGCGGAGCTGCGAACGGCGACGATTGCCATAGCAAATACGTGGCTAACGATGCGGCTGTTTCCCACAATCGATTTGACTGGACCGCGAAACGAAGGAGACGATGATGGTGGCATTCCGCCGGGCTATTTGCGAGAGGGATTTCTGCCGCTGCAACACAGCCTGTCAATGGCTTATTTAAGACAAAAATCGGGGGAACAGGACCTGCCGAATGTGGTGATGAAACGTTATCCGTTTCCCGCCTACA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0031170_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.036
Domain overlap (PFAM):
C1:
PF126982=ABC2_membrane_3=PU(10.6=64.8)
A:
NO
C2:
PF126982=ABC2_membrane_3=PU(24.6=31.5)
Main Inclusion Isoform:
FBpp0297618
Main Skipping Isoform:
FBpp0304764
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
FBpp0304765
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CTCCCTGCTCCTCGTTCTAGT
R:
TCTTCAACACGGGATTGACGG
Band lengths:
167-233
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)