DmeEX0001314 @ dm6
Exon Skipping
Gene
FBgn0027561 | CG18659
Description
This gene is referred to in FlyBase by the symbol DmelCG18659 (FBgn0027561). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (6 unique). Gene sequence location is 2R:9123304..9132030. Its molecular function is described by: Rab GTPase binding; phosphatidylinositol phosphate binding; Rab guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rab protein signal transduction; endocytic recycling; endocytosis. 8 alleles are reported. No phenotypic data is available. No phenotypic class data is available. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period.
Coordinates
chr2R:9123304-9126066:-
Coord C1 exon
chr2R:9125551-9126066
Coord A exon
chr2R:9124744-9125220
Coord C2 exon
chr2R:9123304-9124145
Length
477 bp
Sequences
Splice sites
3' ss Seq
TTGCCCATTGGCCCACGCAGCTT
3' ss Score
3.84
5' ss Seq
GAGGTACAC
5' ss Score
5.99
Exon sequences
Seq C1 exon
GGGGCATGAAGACCGCCTATAAGGGATTCAAGACAAAGCTGCGCGAGAACGGAAACCAGTTTGGTGGCACGCACTTCCACTTTGGACTTGGCTCCCCGAATCATTCGGATCGTCCTGACGGCACCAGCGGAGGATACGTTCGTGGTGGCAAGGCCATCGGGGCTGCACACCACTCGGCGCCCAGTTCTCCAGTGACCAGCAAGCGTCTTGATGGAATTGCCTCCGTCACGGGAAGCAGCGGCAGCGGTGGATCCGGCGCCAGGGAGCCGCGGGAGTTCCTGCGACGCGGTCCCGTCCCGCTGGCCATGTCTAGCTCGAGCAGCCACATTCAGCCGAACGGCCATGCGTACGGTGCGAGTGCTGGTGCTCATTATGGTCATCATCTCGCTGCGTCTCCTGCTGTTAGCTCGGCGAGCTCGCTCTGCTCATCTTCGGAGATGAACCTGTCGCAGGAACTGCAGAACCATCCGCTTTTCAAGACGCCGGCAGTGGACCGCAGC
Seq A exon
CTTAAGCCAAACGCAGAGCACAGGCGAGGAGCAGCACCGCCAGCCCGTCCACCGCCACCGCAATCTACGCCCGCCTCCTACTACAATCATCCCTATGCCGCGCATCCGCACGTGGAGTCTAAGCCGCCAAGGCACACCTCCACGCCCACCAGACCGCGTCAGCCCCTGCCTACCGCCGATTCCAGCAGCTTTGATAGTCCGCCGGACGTACAATCTCCACCGATTCCGCCCCGGAGGCAGGGCAGCTCGAATGCGATTGTGGCGGCCACGGCTGCAGCCGTCAGTGCAGAGATTAGCAAACTGGAACGTAACTGCTGGAAGGACGAGCCCGGAAATGATTCTGTACGCAGCTCGAATGCATCCTCGTCATCGGCGACCTCATCCTCCTCGGGCGCATCGTTTGTGACGGCGGCGTCGACGTTCTCGCATCTTAATGTGTCTGATCCGCCCATTCCGACACCGCGGGCCAAGAGAGAG
Seq C2 exon
CAACAGCAGCCACTGGAGGACAGCATGAATGATCTGATATCGCTGGACGATAGCAACAACACCAGCTTCGACCTGGAGGACTTCGATCCGCTCAATCAGAATGCTCGTCCGTTGCCGCCGCTCAGCACGGCATTTGCCAAGAAGTGCAGCACACTGCCCGCTGGCGTCAACAGCAGTGTGGTGGCCAGTAGCGTCAGCAATCCACTGTACCCGTATTTCGCGCCCAAGCACATGGCCACGGTGGCAGCTGTGACGGGACGGACGCCACCGATGCACCCACCGCCGCAGATCCAGCGCAACACCATTGCCGCCAAGCCCGACGACGACTTCGAGCTGCTCCGCAAGTACGGCCTGGACCAGTTCACCCTGAACGCCAACGGAACGGAGAAGTCGCAGCAGCTCACCACCGGAAAGGGCATGAACAACTGGACAACATTCGATTGAAGGGACACAGCTGGTCAGATAACCTGCATCAAATATGATACCAAAATAAGTGTGAT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0027561-'15-13,'15-12,17-13
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.847 A=0.898 C2=0.599
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0087707
Main Skipping Isoform:
FBpp0291660
Other Inclusion Isoforms:
FBpp0291659, FBpp0297474, FBpp0308463
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCGAGTGCTGGTGCTCATTAT
R:
ACAGTGGATTGCTGACGCTAC
Band lengths:
355-832
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)