DmeEX0004197 @ dm6
Exon Skipping
Gene
FBgn0000581 | E(Pc)
Description
The gene Enhancer of Polycomb is referred to in FlyBase by the symbol DmelE(Pc) (CG7776, FBgn0000581). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (4 unique). Gene sequence location is 2R:11452043..11465270. Its molecular function is described by: histone acetyltransferase activity. It is involved in the biological process described with: dendrite guidance; regulation of transcription by RNA polymerase II; histone exchange; chromatin organization; histone acetylation. 25 alleles are reported. The phenotypes of these alleles manifest in: external sensory organ; external sensillum; tergum; adult neuron; posterior crossvein. The phenotypic classes of alleles include: phenotype; increased mortality; neuroanatomy defective; modifier of variegation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.
Coordinates
chr2R:11455588-11456734:+
Coord C1 exon
chr2R:11455588-11455755
Coord A exon
chr2R:11455820-11456001
Coord C2 exon
chr2R:11456367-11456734
Length
182 bp
Sequences
Splice sites
3' ss Seq
TACTCCTTGTTTATTTGCAGACC
3' ss Score
8.81
5' ss Seq
TGGGTAAGG
5' ss Score
9.08
Exon sequences
Seq C1 exon
ACGTGACCTGCAGCGCGCCACCACTATACTGGAGATGGTGAGGCGACGCGAGGAGACGAAGCGCGATCATCTCAAGATGACGGTGAACATCTTCGAGAAGCGCGTTGAGATGCGCGACTTCAACGGTGCTGTCTACTCCGAGCTGAATTCTCAGTACAAGAACACAAG
Seq A exon
ACCCGCGTATAATCCATTGTATACGAATCAATACTCACAAGGGGCGGCGGCGGTGGGAACGGCTGGTGCCATTCTAGCCGCCCTGCCCACGGGTCTGCTGCCGGGCGGTGCTGGAGCGGCAGGCAATGCAAATGTCTTCGGCTCAGCGTCCCAGTACCTGAACTCGTCGAATCTGACAATGG
Seq C2 exon
ATGCCATCAGTGGCAGTGGGAATGGAAACAGCAGTCGCAAGGAGAAGCGTCCATACAAGAAGCGCAAGCACAAATTGCCCCGCGACAAGCAGCAGCACCAGCAGCAGCAAACGCAGCAGCACCAGCAACAACAGTATTTGCCGGCGTCTGGTGGCGCCGGAGTCTCGCCCGCGCACCACCTGCCCCACCATCTGCACCACCTCAGCAGGCAGCAGAGTGCCTCGCCGGCAGCCAACGACTCGATTGCGGACAGCGAGGAGGAGGACTACTTTGGCGCCGGTGCCCAGAATGGAAACAAACTGGGCTCCGAGAGCGAGGAGGAGACGCCGTTTGCATTTAGGCGCAGATCAAGCTGTGTTTACCTACCG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000581_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.317 A=0.387 C2=0.885
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0303472
Main Skipping Isoform:
FBpp0303471
Other Inclusion Isoforms:
FBpp0087238, FBpp0087239, FBpp0303473
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
CGAAGCGCGATCATCTCAAGA
R:
CGCCGGCAAATACTGTTGTTG
Band lengths:
258-440
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)