Special

DmeEX0004826 @ dm6

Exon Skipping

Gene
FBgn0039081 | Irk2
Description
The gene Inwardly rectifying potassium channel 2 is referred to in FlyBase by the symbol DmelIrk2 (CG4370, FBgn0039081). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3R:23513617..23519445. Its molecular function is described by: inward rectifier potassium channel activity. It is involved in the biological process described with: potassium ion import across plasma membrane; regulation of membrane potential; regulation of ion transmembrane transport; potassium ion transport; wing disc development. 10 alleles are reported. The phenotypes of these alleles manifest in: adult sense organ; imaginal tissue; chaeta; wing vein L3; mesothoracic bristle. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; some die during larval stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.
Coordinates
chr3R:23518458-23519445:-
Coord C1 exon
chr3R:23519233-23519445
Coord A exon
chr3R:23519151-23519177
Coord C2 exon
chr3R:23518458-23518705
Length
27 bp
Sequences
Splice sites
3' ss Seq
TAACAAAATCTCGATTTAAGGGT
3' ss Score
5.59
5' ss Seq
AAGGTGATA
5' ss Score
4.18
Exon sequences
Seq C1 exon
TCGGCCGTCATTTAATCCATTGGTCGGACTTGCGGATCCGTAGATTCGCTGTGACAGTTGCTCTGTGGCTCTGAGTGCCCTCTGATCTCCAGTCCTCAGATCATCTCATTTCTGGAACGACACGCGTCGGCAAAACATAACGAAACGGAGCTTGTGAAACTAAAACATTGTGCCTATTATCAGTTCGCAACATGCCATCATAAAGTGCCAAAA
Seq A exon
GGTGTCAATCAATTTAATATCTAAAAG
Seq C2 exon
ATGCGTTTCAATTTCTCCACCCACTCGGCGGCCCCCACCTCTACGACCATACCAACAACAACACAGGCAAATGGAGGCGAACAGGCCACCCAACCGCTCAAGAAGGCCATCGAAGCGGATCCCGATTCGCTGGACAGTGTGATCAGCAATCCTCAATCCTATCCCATCACAATTGTGCCGAATAGGCCGACCAGCTACTATGGCCTATCCCAAAATGGCAAGCCGTTCCCCCGCCAACCGAGCTGCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0039081_CASSETTE2
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

5' UTR

No structure available
Features
Disorder rate (Iupred):
  C1=NA A=NA C2=0.590
Domain overlap (PFAM):

C1:
NA
A:
NA
C2:
NO


Main Inclusion Isoform:
NA


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TCAGTTCGCAACATGCCATCA
R:
GCCTCCATTTGCCTGTGTTGT
Band lengths:
112-139
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)