FBgn0039081 @ dm6

Biotype

protein_coding

Gene Symbol

Irk2

Description

The gene Inwardly rectifying potassium channel 2 is referred to in FlyBase by the symbol DmelIrk2 (CG4370, FBgn0039081). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3R:23513617..23519445. Its molecular function is described by: inward rectifier potassium channel activity. It is involved in the biological process described with: potassium ion import across plasma membrane; regulation of membrane potential; regulation of ion transmembrane transport; potassium ion transport; wing disc development. 10 alleles are reported. The phenotypes of these alleles manifest in: adult sense organ; imaginal tissue; chaeta; wing vein L3; mesothoracic bristle. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; some die during larval stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.

Coordinates

chr3R:23513617-23519445:-

Assembly

dm6

GENOMIC BROWSER[edit]

EXPRESSION VALUES[edit]

SPECIAL DATASETS

Neural diversity
Neurogenesis
Neuronal activity
Splicing factor regulation (brain)
Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event

Type

Length

Coordinates

Strand

PSI Average

PSI Range

Annotated Functions

DmeEX0004825

Exon Skipping

115

chr3R:23514209-23514323

-

85.79

95.19

0

DmeEX0004826

Exon Skipping

27

chr3R:23519151-23519177

-

87.81

30.54

0

DmeINT0021904

Intron Retention

53

chr3R:23514324-23514376

-

4.1

53.54

0

Orthologous genes[edit]

Organism	Assembly	Gene ID	Gene Name	Orthology Type
Human	hg38	ENSG00000120457	KCNJ5	2-to-15
Human	hg38	ENSG00000151704	KCNJ1	2-to-15
Human	hg38	ENSG00000162728	KCNJ9	2-to-15
Human	hg38	ENSG00000182324	KCNJ14	2-to-15
Human	hg38	ENSG00000187486	KCNJ11	2-to-15
Human	hg19	ENSG00000120457	KCNJ5	2-to-15
Human	hg19	ENSG00000151704	KCNJ1	2-to-15
Human	hg19	ENSG00000162728	KCNJ9	2-to-15
Human	hg19	ENSG00000182324	KCNJ14	2-to-15
Human	hg19	ENSG00000187486	KCNJ11	2-to-15
Mouse	mm10	ENSMUSG00000030247	Kcnj8	2-to-14
Mouse	mm10	ENSMUSG00000041248	Kcnj1	2-to-14
Mouse	mm10	ENSMUSG00000041695	Kcnj2	2-to-14
Mouse	mm10	ENSMUSG00000042529	Kcnj12	2-to-14
Mouse	mm10	ENSMUSG00000058743	Kcnj14	2-to-14
Mouse	mm9	ENSMUSG00000030247	Kcnj8	2-to-14
Mouse	mm9	ENSMUSG00000041248	Kcnj1	2-to-14
Mouse	mm9	ENSMUSG00000041695	Kcnj2	2-to-14
Mouse	mm9	ENSMUSG00000042529	Kcnj12	2-to-14
Mouse	mm9	ENSMUSG00000058743	Kcnj14	2-to-14
Rat	rn6	ENSRNOG00000001658	Kcnj6	2-to-14
Rat	rn6	ENSRNOG00000021056	Kcnj14	2-to-14
Rat	rn6	ENSRNOG00000021128	Kcnj11	2-to-14
Rat	rn6	ENSRNOG00000033796	Kcnj5	2-to-14
Rat	rn6	ENSRNOG00000059005	Kcnj1	2-to-14
Cow	bosTau6	ENSBTAG00000000973	KCNJ15	2-to-13
Cow	bosTau6	ENSBTAG00000006159	KCNJ3	2-to-13
Cow	bosTau6	ENSBTAG00000016170	KCNJ11	2-to-13
Cow	bosTau6	ENSBTAG00000020061	KCNJ12	2-to-13
Cow	bosTau6	ENSBTAG00000024903	KCNJ16	2-to-13
Chicken	galGal4	ENSGALG00000004373	KCNJ16	2-to-15
Chicken	galGal4	ENSGALG00000004721	M2.	2-to-15
Chicken	galGal4	ENSGALG00000012254	cKir2.3	2-to-15
Chicken	galGal4	ENSGALG00000026373	KCNJ8	2-to-15
Chicken	galGal3	ENSGALG00000004373	E1BWC5_CHICK	2-to-15
Chicken	galGal3	ENSGALG00000004721	F1NHE9_CHICK	2-to-15
Chicken	galGal3	ENSGALG00000012254	O73605_CHICK	2-to-15
Zebrafish	danRer10	ENSDARG00000019418	kcnj2a	2-to-31
Zebrafish	danRer10	ENSDARG00000045039	kcnj16	2-to-31
Zebrafish	danRer10	ENSDARG00000060259	zgc:162160	2-to-31
Zebrafish	danRer10	ENSDARG00000089060	kcnj1a.5	2-to-31
Zebrafish	danRer10	ENSDARG00000090635	kcnj1a.4	2-to-31