DmeEX0004916 @ dm6
Exon Skipping
Gene
FBgn0063485 | Lasp
Description
The gene Lasp is referred to in FlyBase by the symbol DmelLasp (CG3849, FBgn0063485). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3L:16676406..16711677. Its molecular function is described by: protein binding; actin filament binding; actin binding. It is involved in the biological process described with 7 unique terms, many of which group under: regulation of multicellular organismal process; cellular component assembly involved in morphogenesis; regulation of system process; regulation of myofibril size; positive regulation of oocyte development. 41 alleles are reported. The phenotypes of these alleles manifest in: germline cyst; adult integumentary system; external sensory organ; spermatid cyst; adult. The phenotypic classes of alleles include: phenotype; lethal - all die before end of P-stage; increased mortality during development; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages.
Coordinates
chr3L:16678425-16680947:-
Coord C1 exon
chr3L:16680812-16680947
Coord A exon
chr3L:16678808-16679473
Coord C2 exon
chr3L:16678425-16678660
Length
666 bp
Sequences
Splice sites
3' ss Seq
CTCACATCTGTATCCCACAGCAA
3' ss Score
8.17
5' ss Seq
GTGGTAAGT
5' ss Score
10.36
Exon sequences
Seq C1 exon
GTGGCCGATGACCCGGAAACGCTGCGTATCAAACAGAACACGAAGCACATATCGAATGTGGCATATCACGGGGATCTGGAGAAGAAGGCGGCCATGGAGAAGCAGCGAGGATCCGCCGAGGTCTCCGACAGCAGCA
Seq A exon
CAACATCCCAGCAGCAACAGATGCCGCCACCACAGTCGCCGGCGAATCCGCAGCAGCAGGCGCTCAACAGCTACAACGAGATGCGCTCGGCCATACTCCAGAACTCGCATCATCCCAGCGGCAATTCCGTGGATCAGTACGACCAGCCACAGCAGCAGCAACATCAGCCGCAACAGCAGAGCACCAACCCCACGCTGGTGGCTGCCCAACAGCAGCAATCCCATCATAGCCTACTGAACAACAATGCCAGCAACGGCGGCATTTCGCACAGCCACCACAGCAACATCAATAATAATGGACACGGCTCACAGAACCAAATGTTGCCGCCACAAATGAGACGCTCGGCGGCCAGTGTCGTCGCCTACGATGGCAATAGCAAGCAACAAGTGGCAGCCGGCCCAGGAGCTGCCCAAAATCACCTGCAGCAATTATACGCGTCTCCCAATTACGCCGCTGTGACTCCATCTGAGAATTCAATAAACGTTAAGCAGCACGCCAGCAATGGCCATATGCCGAACCAGCAGCAACAGCACGTGGCAGGCGGCAGCAATATCGGGAAGATAGCGGACTACGATCCACTGACGGATGGACCAAGGGTGGTGCCCAATGCCGGACGGTCCAGCACCACTTTGGTCTACAGCTCCGAGCCACGTGGCAATCAAGGTG
Seq C2 exon
GCAACAGCGTTTACCCCAAGCGGATTGGTTCGGTTTCCGATATTGATCCGGCCAATGGCATCTACGGATCGCTCACCGCCGCCGAGCAGGCTCACCAGCAGCAGAAGCACCAGCAGTACTACCAGCAGGTACAGATGATGCAGCAGCAGGAGCACCCGCCGCAGCAACAGCAGATGCGCCAGCAGCCATCCTACTCCTCCCTGCAGGAAAAACAATCGCGCCAGAGCACAGCAATG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0063485_CASSETTE1
Average complexity
S*
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.967 A=0.998 C2=0.864
Domain overlap (PFAM):
C1:
PF0088013=Nebulin=WD(100=63.0)
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0075109

Main Skipping Isoform:
FBpp0297282

Other Inclusion Isoforms:
FBpp0099495, FBpp0297281
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg38)
No conservation detected
Human
(hg19)
No conservation detected
Mouse
(mm10)
No conservation detected
Mouse
(mm9)
No conservation detected
Rat
(rn6)
No conservation detected
Cow
(bosTau6)
No conservation detected
Chicken
(galGal4)
No conservation detected
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
ACGCTGCGTATCAAACAGAACA
R:
CTGGCGCGATTGTTTTTCCTG
Band lengths:
342-1008
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)